Találati lista | Tudóstér

001-es BibID:	BIBFORM073441
035-os BibID:	(WoS)000436922100013 (Scopus)85047246921
Első szerző:	Tsikouras, Panagioti
Cím:	Blood rheology during normal pregnancy / Panagiotis Tsikouras, Barbara Niesigk, Georg-Friedrich von Tempelhoff, Werner Rath, Olga Schelkunov, Peter Daragó, Roland Csorba
Dátum:	2018
ISSN:	1386-0291
Megjegyzések:	INTRODUCTION: Recent studies have shown increased RBC aggregation and no difference in plasma viscosity in thepresence ofmarkedly lower hematocrit inwomen at termcompared to non-pregnantwomen. Little is known about the outcomeof blood rheological parameters and red blood cell (RBC) deformability particularly in the course of normal pregnancy.METHODS: During a 36 months interval 1.913 blood samples were randomly collected from a total of 945 pregnantwomen in the course of their pregnancy (n = 1.259) and during puerperium (upto 1 week; n = 654). Next to the bloodcount, hemorheological parameters including red blood cell (RBC) -aggregation (stasis E0; low shear E1), -deformability(low, moderate and high shear conditions) and plasma viscosity (pv) were assessed. Plasma viscosity (pv) was examinedusing KSPV 1 Fresenius, RBC aggregation (stasis: E0 and low shear: E1) using MA1-Aggregometer; Myrenne and RBCdeformability (def) was determined by Rheodyn SSD Diffractometer, Myrenne, Roetgen, Germany were tested. In someof these women laboratory results prior to pregnancy (n = 145) were available which were compared with those duringpregnancy.RESULTS: Mean maternal pv remained unchanged within each trimester and compared to the values before pregnancyand during early puerperium (Range of means: 1.18?1.20mPa S). In contrast, RBC agg (E0 and E1) was markedly higherin the 2nd (21.8?7.0 and 28.9?9.4; p < 0.001) and 3rd trimester (18.74?8.4 and 28.2?9.4; p < 0.01) compared to thevalues before pregnancy (16.4?6.4 and 20?7.5) and during 1st trimester (17.49?6.5 and 22.4?7.4). There was a stat.significant temporary reduction in RBC def. under all shear rate conditions during 2nd trimester compared to the valuesbefore pregnancy which remained significantly lower during 3rd trimester only under high shear rates.An increase RBC agg was stat. significantly inversely correlated with reduced RBC def being most pronounced under lowshear rate conditions. While RBC rigidity was stat. significantly correlated with higher hematocrit values there was only aweak correlation between RBC agg and haematocrit (E0: r = ?0.084; p = 0.03; E1: r = ?0.06; p = 0.1). Pv was not correlatedwith haematocrit or RBC def but stat. significantly correlated with RBC agg.CONCLUSION: Blood rheological changesmanifest during 1st trimester, and fairly remain unchanged during 2nd trimesteruntil term. Physiologic hemodilution and increasing hypercoagulability is accompanied by high RBC -aggregation and?rigidity during 2nd trimester while plasma viscosity remains nearly unaffected throughout normal pregnancy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Clinical Hemorheology and Microcirculation. - 69:1-2 (2018), p. 101-114. -
További szerzők:	Niesigk, Barbara Tempelhoff, Georg-Friedrich von Rath, Werner Schelkunov, Olga Daragó Péter Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM072241
Első szerző:	Tsikouras, Panagioti
Cím:	Predictive value of fetal scalp pH and base excess for fetal acidosis and poor neonatal outcome / Tsikouras Panagiotis, Koukouli Zacharoula, Niesigk Barbara, Manav Bachar, Farmakides George, Csorba Roland, Galazios Georgios, Teichmann Alexander Tobias
Dátum:	2018
ISSN:	1476-7058 1476-4954
Megjegyzések:	Objective: The objective of this study is to assess retrospectively the predictive value of fetal scalp pH and base excess (BE) for fetal acidosis and poor neonatal outcome in term, low-risk, spontaneous deliveries with suspicious or pathological intrapartum cardiotocography (CTG) tracings. Methods: Umbilical artery pH and BE values obtained immediately after delivery and Apgar score were the outcomes under consideration. Statistics included receiver-operating characteristic curve (ROC) and multiple logistic regression analysis. Results: Four hundred and six deliveries were included in the study. Scalp pH?<?7.20 predicted umbilical pH ?7.1 with 64.3% sensitivity and 92.9% specificity (p?<?.001). The corresponding positive-predictive value (PPV) was 24.3% and the negative-predictive value (NPV) was 98.6%. Scalp BE????7?mmol/l (a cut-off value provided by ROC curve analysis) predicted Apgar score???7 at 5?min with 61.9% sensitivity and 91.7% specificity (p?<?.001). The corresponding PPV and NPV were 29.5 and 97.7%, respectively. Neither scalp pH nor BE was significantly associated with umbilical BE values. Infants with intrapartum BE????7?mmol/l were 30 times on an average more likely to get a low Apgar score, independently of intrapartum pH values. Conclusion: Our study supports the consideration of both scalp pH and BE values, when fetal blood sampling (FBS) is used.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Maternal-Fetal & Neonatal Medicine. - 31 : 23 (2018), p. 3166-3171. -
További szerzők:	Koukouli, Zacharoula Niesigk, Barbara Manav, Bachar Farmakides, George Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Galazios, Georgios Teichmann, Alexander
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: