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001-es BibID:BIBFORM072233
Első szerző:Liatsikos, Spyros A.
Cím:Inherited thrombophilia and reproductive disorders / Liatsikos Spyros A., Tsikouras Panagiotis, Manav Bachar, Csorba Roland, Tempelhoff Georg Friedrich von, Galazios Georgios
Dátum:2016
ISSN:1309-0399 1309-0380
Megjegyzések:Apart from its established role in the pathogenesis of venous thromboembolism (VTE), inherited thrombophilia has been proposed as a possible cause of pregnancy loss and vascular gestational complications. There is a lot of controversy in the literature on the relationship between inherited prothrombotic defects and these obstetric complications. This is a review of the literature on inherited thrombophilia and reproductive disorders. Factor V Leiden, prothrombin G20210A mutation, and protein S deficiency seem to be associated with late and recurrent early pregnancy loss, while their impact on other pregnancy complications is conflicting. No definite association has been established between protein C and antithrombin deficiency and adverse pregnancy outcome, primarily due to their low prevalence. Screening is suggested only for women with early recurrent loss or late pregnancy loss. Anticoagulant treatment during pregnancy should be considered for women with complications who were tested positive for thrombophilia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Inherited thrombophilia
Recurrent pregnancy loss
Reproductive disorders
Megjelenés:Journal of the Turkish German Gynecology Association 17 : 1 (2016), p. 45-50. -
További szerzők:Tsikouras, Panagioti Manav, Bachar Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Tempelhoff, Georg-Friedrich von Galazios, Georgios
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2.

001-es BibID:BIBFORM072232
Első szerző:Tsikouras, Panagioti
Cím:Induction of Labor in Post-Term Nulliparous and Parous Women : potential Advantages of Misoprostol over Dinoprostone = Geburtseinleitung bei übertragenen Schwangerschaften in Nulliparae und Parae - mögliche Vorteile von Misoprostol gegenüber Dinoproston / Tsikouras P., Koukouli Z., Manav B., Soilemetzidis M., Liberis A., Csorba R., Trypsianis G., Galazios G.
Dátum:2016
ISSN:0016-5751
Megjegyzések:Introduction: We undertook a prospective cohort study to compare the effectiveness and safety of 50 ?g misoprostol versus 3 mg dinoprostone in two vaginal doses 6 hours apart, followed if necessary by oxytocin for labor induction in low-risk post-term (> 40 weeks) pregnancies with unfavorable cervix (Bishop score ? 6). Methods: Labor induction and subsequent management were conducted using a standardized protocol. The primary outcome of the study was labor induction rate. Secondary outcomes included mode of delivery, time interval from induction to delivery, maternal complications and neonatal outcome. Results: 107 patients received misoprostol (Group A) and 99 patients received dinoprostone (Group B). Compared with group A, more women in Group B needed a second vaginal dose of prostaglandin or oxytocin infusion in order to proceed to labor (21.5 vs. 43.4 %; p = 0.01). Misoprostol alone as a single or double vaginal dose was more effective than dinoprostone alone in inducing labor without oxytocin administration (85.0 vs. 50.4 %; p = 0.04). Overall, the rate of successful induction of labor did not differ between groups (91.6 vs. 85.8 %; p = 0.75). Vaginal delivery, operative vaginal delivery and Caesarean section rates were not significantly different. Time interval from induction to delivery however, was shorter for Group A (median 11 hours vs. 14.1 hours; p < 0.001). Though emergency Caesarean section due to fetal distress was more frequent in Group A (16.8 vs. 4.0 %; p = 0.007), low Apgar scores < 7 and NICU admissions did not differ significantly. Maternal complications, mostly not serious, were higher in Group A (31.8 vs. 2.0, p < 0.001). Conclusion: Misoprostol is a more effective agent than dinoprost in post-term pregnancy for labor induction with few maternal adverse effects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
dinoprostone
labor induction
misoprostol
post-term pregnancy
Megjelenés:Geburtshilfe Und Frauenheilkunde 76 : 7 (2016), p. 785-792. -
További szerzők:Koukouli, Zacharoula Manav, Bachar Soilemetzidis, M. Liberis, Anastasios Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Trypsianis, G. Galazios, Georgios
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3.

001-es BibID:BIBFORM072241
Első szerző:Tsikouras, Panagioti
Cím:Predictive value of fetal scalp pH and base excess for fetal acidosis and poor neonatal outcome / Tsikouras Panagiotis, Koukouli Zacharoula, Niesigk Barbara, Manav Bachar, Farmakides George, Csorba Roland, Galazios Georgios, Teichmann Alexander Tobias
Dátum:2018
ISSN:1476-7058 1476-4954
Megjegyzések:Objective: The objective of this study is to assess retrospectively the predictive value of fetal scalp pH and base excess (BE) for fetal acidosis and poor neonatal outcome in term, low-risk, spontaneous deliveries with suspicious or pathological intrapartum cardiotocography (CTG) tracings. Methods: Umbilical artery pH and BE values obtained immediately after delivery and Apgar score were the outcomes under consideration. Statistics included receiver-operating characteristic curve (ROC) and multiple logistic regression analysis. Results: Four hundred and six deliveries were included in the study. Scalp pH?<?7.20 predicted umbilical pH ?7.1 with 64.3% sensitivity and 92.9% specificity (p?<?.001). The corresponding positive-predictive value (PPV) was 24.3% and the negative-predictive value (NPV) was 98.6%. Scalp BE????7?mmol/l (a cut-off value provided by ROC curve analysis) predicted Apgar score???7 at 5?min with 61.9% sensitivity and 91.7% specificity (p?<?.001). The corresponding PPV and NPV were 29.5 and 97.7%, respectively. Neither scalp pH nor BE was significantly associated with umbilical BE values. Infants with intrapartum BE????7?mmol/l were 30 times on an average more likely to get a low Apgar score, independently of intrapartum pH values. Conclusion: Our study supports the consideration of both scalp pH and BE values, when fetal blood sampling (FBS) is used.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Maternal-Fetal & Neonatal Medicine. - 31 : 23 (2018), p. 3166-3171. -
További szerzők:Koukouli, Zacharoula Niesigk, Barbara Manav, Bachar Farmakides, George Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Galazios, Georgios Teichmann, Alexander
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