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001-es BibID:	BIBFORM072235
Első szerző:	Tempelhoff, Georg-Friedrich von
Cím:	Thrombelastometric results and platelet function during pregnancy in women receiving low molecular weight heparin with a history of recurrent/late abortion : a retrospective analysis / von Tempelhoff Georg-Friedrich, Schelkunov Olga, Demirhan Attila, Tsikouras Panagiotis, Rath Werner, Velten Eva, Csorba Roland
Dátum:	2015
ISSN:	1386-0291
Megjegyzések:	In women with a history of recurrent/late abortion and confirmed genetic/acquired thrombophilia, LMWH was given during subsequent pregnancy and serial coagulation testing was performed. In 82 consecutive pregnant women with recurrent (?2) and/or late abortion (>12 GW) in the presence of single (n = 62; 75.6) or combined (n = 20; 24.4) genetic and/or acquired thrombophilia, Thromboelastometry (n = 50; ROTEM, TEM) and closure-time (n = 82; PFA-100; Siemens) underwent serial testing before and during pregnancy while receiving LMWH and puerperal. Throughout pregnancy, clotting-time (CT) after intrinsic and extrinsic induced coagulation activation in Thromboelastometry remained unchanged. TF-induced coagulation activation resulted in statistically significantly decreased mean clot-formation-times (CFT) (Trim I: 108.9 ? 5.2 S to Trim III; 81.7 ? 5.4 S; p = 0.001), whereas after contact activation (Intem-S: Trim I: 70.1 ? 4.0 S to Trim III: 65.4 ? 6.8; n.s.) CFT remained unchanged. Mean maximal-clot-firmness (MCF) continuously increased in the Intem-S and Extem-S during each trimester and decreased until 4th puerperal week (Extem-S: Trim I: 61.9 ? 1.0 S; Trim II: 65.4 ? 0.58 S; Trim III: 68.3 ? 1.1 S; p < 0.001; Intem-S: Trim I: 64.1 ? 0.6 S; Trim II: 66.8 ? 0.5 S; Trim III: 69.5 ? 1.2 S; p < 0.001). Mean Closure-times after Epinephrine/ADP/Collagen stimulation remained unchanged during pregnancy. In women with different thrombophilia receiving LMWH at prophylactic dose a significant increase in MCF was accompanied by barely unchanged CT after intrinsic and extrinsic coagulation activation and platelet mediated closure-times in the course of the pregnancy. Decrease in CFT was only seen after extrinsic coagulation activation, whereas unchanged CFT after intrinsic coagulation activation may be the result of LMWH given at low dose.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban low-molecular-weight-heparin platelet-function-analyser Pregnancy recurrent abortion Thromboelastometry
Megjelenés:	Clinical Hemorheology And Microcirculation 61 : 1 (2015), p. 99-110. -
További szerzők:	Schelkunov, Olga Demirhan Attila Tsikouras, Panagioti Rath, Werner Velten, Eva Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM072234
035-os BibID:	(Wos)000371008900006 (Scopus)84959020058
Első szerző:	Tempelhoff, Georg-Friedrich von
Cím:	Correlation between blood rheological properties and red blood cell indices(MCH, MCV, MCHC) in healthy women / von Tempelhoff Georg-Friedrich, Schelkunov Olga, Demirhan Attila, Tsikouras Panagiotis, Rath Werner, Velten Eva, Csorba Roland
Dátum:	2016
ISSN:	1386-0291
Megjegyzések:	OBJECTIVE: Structure and mechanical properties of red blood cells are markedly influenced by pathophysiology of many diseases which in turn potentially impair microcirculatory blood flow. The physiological association between blood rheological parameters and red blood cell indices was investigated in otherwise healthy unselected mid-age women prior to elective gynaecological surgery. METHODS: Red Blood Cell-deformability (RBC 1.2, 3.0; 6.0, 12.0; 30.0, 60.0) during exposure to low (RBC 1.2, 3.0), moderate (RBC 16.0, 12.0) and high shear forces (RBC 30.0, 60.0; Rheodyn; Myrenne), -aggregation (MA1; Myrenne) during low shear (E1; 4-1 S) and in stasis (E0) and plasma viscosity (Pv; KSV 1; Fresenius) were correlated with red blood cell indices (RBC-I: MCV, MCH and MCHC) and subjects' characteristics in 286 healthy women the day before undergoing gynaecologic standard surgery. Women with known pregnancy, malign-, infective-, chronic-disease or extreme BMI (<16; >40 Kg/m2) were excluded from this trial. RESULTS: From June 2014 to December 2014 a total of 286 healthy women (age: 46.5?17.6 y; BMI: 25.5?5.2 kg/m2) were eligible for inclusion into this prospective evaluation. Pv (mean?SD: 1.17?0.12 mPa s) and RBC aggregation (E0:12.6?6.3; E1:17.9?7.3) were not significantly correlated with RBC-I but with age and BMI. In contrast, RBC-deformability correlated significantly with MCV and MCH but significantly inversely correlated with MCHC. Deformability significantly increased with age but was unaffected by BMI of women. The correlation between RBC-I and RBC deformability was most remarkable during moderate shear force exposure. Neither haemoglobin nor haematocrit were correlated with RBC deformability or RBC-I. CONCLUSIONS: Cell volume and haemoglobin content had a strong impact on deformability in apparently healthy mid age women, whereas low MCHC and large MCV were associated with an increase in deformability while high MCHC and small MCV correlated with increased rigidity of RBC. BMI had no impact on deformability while age was associated with an increase in all determinants of blood viscosity. RBC aggregability was not affected by MCV, MCHC or MCH in mid-age women.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk MCHC MCV Plasma viscosity red blood cell aggregation red blood cell deformability MCH
Megjelenés:	Clinical Hemorheology And Microcirculation. - 62 : 1 (2016), p. 45-54. -
További szerzők:	Schelkunov, Olga Demirhan Attila Tsikouras, Panagioti Rath, Werner Velten, Eva Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász)
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