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001-es BibID:	BIBFORM114373
035-os BibID:	(WoS)001004122600001 (Scopus)85168485988
Első szerző:	Gerszi Dóra
Cím:	Risk Estimation of Gestational Diabetes Mellitus in the First Trimester / Dóra Gerszi, Gergő Orosz, Marianna Török, Balázs Szalay, Gellért Karvaly, László Orosz, Judit Hetthéssy, Barna Vásárhelyi, Olga Török, Eszter M. Horváth, Szabolcs Várbíró
Dátum:	2023
ISSN:	0021-972X
Megjegyzések:	Purpose: There is no early - first trimester- risk estimation available to predict later (gestational week 24-28) gestational diabetes mellitus (GDM) - however it would be beneficial to start an early treatment to prevent the development of complications.We aimed to identify early, first trimester prediction markers for GDM. Methods: The present case-control study is based on the study cohort of a Hungarian biobank containing the biological samples and follow-up data from 2545 pregnant women. Oxidative-nitrative stress-related parameters, steroid hormone, and metabolite levels were measured in the serum/plasma samples collected at the end of the first trimester from 55-55 randomly selected control and later GDM women. Results: Pregnant women, who developed GDM later during the pregnancy were older and had higher body mass indexes (BMI). The following parameters showed higher concentration in their serum/plasma samples: fructosamine, total antioxidant capacity (TAC), testosterone, cortisone, 21-deoxycortisol; while soluble urokinase plasminogen activator receptor (SuPAR), dehydroepiandrosterone sulfate (DHEAS), dihydrotestosterone (DHT), cortisol and 11-deoxycorticosterone levels were lower. Analyzing these variables using a forward stepwise multivariate logistic regression model we established a GDM prediction model with a specificity of 96.6% and sensitivity of 97.5% (included variables: fructosamine, cortisol, cortisone, 11-deoxycorticosterone, SuPAR). Conclusions: Based on these measurements we accurately predict the development of later onset GDM (24th-28th weeks of pregnancy). Early risk estimation provides the opportunity for targeted prevention and the timely treatment of GDM. Prevention and slowing the progression of GDM result in a lower lifelong metabolic risk for both mother and offspring.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk GDM early risk estimation first trimester oxidative-nitrative stress steroid metabolites
Megjelenés:	Journal Of Clinical Endocrinology & Metabolism. - 108 : 11 (2023), p. e1214-e1223. -
További szerzők:	Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) Török Marianna Szalay Balázs Karvaly Gellért Orosz László (1984-) (szülész-nőgyógyász) Hetthéssy Judit Vásárhelyi Barna Török Olga (1956-) (szülész-nőgyógyász, humángenetikus) Horváth Eszter Mária Várbíró Szabolcs
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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