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1.

001-es BibID:BIBFORM040216
Első szerző:Hernádi Zoltán (szülész-nőgyógyász, klinikai onkológus)
Cím:Duration of HPV-associated risk for high-grade cervical intraepithelial neoplasia / Hernádi Z., Gazdag L., Szőke K., Sápy T., Krasznai Z. T., Kónya J.
Dátum:2006
ISSN:0301-2115
Megjegyzések:OBJECTIVE: To evaluate the duration of high-risk HPV-associated cancer risk. STUDY DESIGN: Patients who had had a routine diagnostic Hybrid Capture Tube Test (HCT) due to squamous cell abnormalities of the uterine cervix were followed-up until the endpoint of histologically diagnosed cervical intraepithelial neoplasia (CIN). RESULTS: Six hundred and thirty-eight women were followed during a cumulative follow-up of 16,423 patient months. The adjusted relative risk associated with the positive HR-HCT test for high-grade CIN/52.0 (20.9-19.2)/ proved to be higher than that of the cytological atypia/5.44 (2.52-11.77)/. At the end of the 30 months of follow-up the crude and adjusted risks for CIN2+ were 214.3 (28.4-1615.7) and 196.7 (25.4-1525.2), respectively in the HPV 16/18 group, and after 30 months, the crude and adjusted RR decreased to 57.6 (10.4-318.9) and 29.2 (5.02-170.0). In the groups of other high-risk types and possibly high-risk types the general tendency was the same. However, new CIN2+ cases were not detected after the 30th month of follow-up in these later groups. CONCLUSIONS: HPV16/18 associated relative risk is nearly 200 times higher than that of the HPV negative population and an outstanding risk persists with duration of about 30 months. The risk is manifested in progression to high-grade CIN lesions mainly within a 2 years interval after the first detection of HPV 16/18 infection.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Obstetrics Gynecology And Reproductive Biology. - 125 : 1 (2006), p. 114-119. -
További szerzők:Gazdag László Szőke Krisztina Sápy Tamás (1970-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Kónya József (1964-) (szakorvos, klinikai mikrobiológus)
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2.

001-es BibID:BIBFORM028354
Első szerző:Hernádi Zoltán (szülész-nőgyógyász, klinikai onkológus)
Cím:Role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical precancerous lesions / Hernádi Z., Szőke K., Sápy T., Krasznai Z. T., Soós G., Veress G., Gergely L., Kónya J.
Dátum:2005
Megjegyzések:To evaluate the role of human papillomavirus (HPV) testing in post-treatment follow-up of patients after therapeutic excision of the cervix due to positive screening tests. STUDY DESIGN: A hospital-based retrospective analysis was performed with prospective collection of patient data of women screened for cervical cancer at a Gynecologic Outpatient Clinic. Patients after therapeutic excision due to positive screening results were identified and followed up with HPV testing and serial cytology. RESULTS: After 61 treatment for cervicalis intraepithelialis neoplasia (CIN), high-risk HPV infection was detected during the post-treatment follow-up at 18 cases (29.5%), 10 of them had persisting cytological atypia (positive predictive value (PPV): 56%), 5 developed CIN (PPV: 28%). When the HPV test was negative (43 patients) in the post-treatment period, neither CIN nor persisting cytological atypia developed (negative predictive value (NPV): 100%) during 1201 patient months (median 26 months). CONCLUSIONS: A negative HPV test eliminates the risk of recurrent disease after treatment for CIN.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
HPV
Megjelenés:European Journal of Obstetrics & Gynecology and Reproductive Biology. - 118 : 2 (2005), p. 229-234. -
További szerzők:Szőke Krisztina Sápy Tamás (1970-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Soós Györgyike (1959-) (pathológus) Veress György (1966-) (biológus, mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus)
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3.

001-es BibID:BIBFORM014054
Első szerző:Hernádi Zoltán (szülész-nőgyógyász, klinikai onkológus)
Cím:The prevalence of the HPV 16 genome, integrated viral status and p53 genotype in cervical cancer population of north-eastern Hungary, the correlation with the established markers of tumour progression / Zoltán Hernádi, Tamás Sápy, Zoárd T. Krasznai
Dátum:2004
ISSN:0301-2115
Megjegyzések:Objectives: To evaluate the prevalence of the HPV 16 integrated status and the p53 genotype in cervical cancer in north-eastern Hungary and their correlation with the established prognostic factors. Study design: Parallel with the routine histological examination, Southern blot hybridisation and multiplex PCRs were used to detect type/physical state of HPV DNA in primary tumours and in regional lymph nodes combined with p53 genotyping of 83 patients. Results: 46.9% (39/83) prevalence rate of HPV 16 genome was found. The frequency of viral integration (76.9% in primary tumours and 95.2% in regional lymph nodes) and that of the p53Arg homozygous genotype (64.1%) proved to be higher than reported from other parts of the world. The HPV 16 integration and the p53 genotype, failed to correlate with the FIGO stage and lymphatic spread. Conclusion: The prevalence of the integrated status of the HPV 16 genome combined with homozygous p53Arg genotype is relatively high in Hungary. These factors however failed to show a strong correlation with the established markers of tumour progression.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Obstetrics Gynecology and Reproductive Biology 113 : 1 (2004), p. 83-86. -
További szerzők:Sápy Tamás (1970-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász)
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4.

001-es BibID:BIBFORM028353
Első szerző:Sápy Tamás (szülész-nőgyógyász)
Cím:Poor clinical outcome in early stage cervical cancer with human papillomavirus-18 positive lymph nodes / T. Sápy, Z. Hernádi, J. Kónya, L. Lukácskó
Dátum:2000
Megjegyzések:Epidemiologic and molecular studies have proven that human papillomavirus (HPV) plays an important role in the development of cervical cancer. However, the role of the virus in the progression of the disease, i.e. in the development of lymph node metastasis and in the adverse clinical outcome is poorly understood. We have been using the polymerase chain reaction (PCR) to study the presence and typing of human papillomavirus DNA since 1980 in cervical cancers and pelvic lymph nodes from the same patients. Out of the series of 47 cervical cancer patients we focused on four women (age: 41, 33, 35 and 56 years) in this article. The follow-up of these patients revealed early recurrences of the disease (7, 7, 17, 22 months) with very short survival (9, 10, 21, 24 months). Although we detected HPV-18 positivity both in the cervical tumors and in the regional lymph nodes too in all four cases, lymph nodes were negative by routine hystology in case of the three young patients (21, 33, 35 years of age). Our observations suggest that HPV type 18 positive cervical cancer patients, despite negative histological findings in the lymph nodes should be consider as a subpopulation for poor outcome especially in the young age group (p=0,022, Fisher's exact test).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
HPV
Megjelenés:European Journal of Obstetrics, Gynecology, and Reproductive Biology. - 90 : 1 (2000), p. 93-95. -
További szerzők:Hernádi Zoltán (1948-) (szülész-nőgyógyász, klinikai onkológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Lukácskó Lóránd
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5.

001-es BibID:BIBFORM001546
Első szerző:Sápy Tamás (szülész-nőgyógyász)
Cím:Age-specific prevalence of high-risk human papillomavirus infection in a Hungarian female population with positive cytology / Sápy Tamás, Póka Róbert, Szarka Krisztina, Kónya József, Huga Sándor, Hernádi Zoltán
Dátum:2008
Megjegyzések:Patients with positive screening results and persistence of high-risk human papillomavirus (HPV) infection represent the population at the highest risk for developing cervical cancer. To describe the epidemiology in this high-risk population, data were collected and analysed at the referral centre for patients with positive cytology. STUDY DESIGN: Between January 1997 and December 2002 the authors performed 3480 virus identifications using the Digene Hybrid Capture((R)) system in a female population with positive cytology at cervical cancer screening. Age-specific prevalence data were evaluated and compared between the age groups by running the chi(2) and Pearson chi(2) tests. Subgroup analysis was performed to estimate monthly clearance rates among eligible women with positive HR-HPV results. RESULTS: Low-risk (LR), high-risk (HR) and double infections were detected in 91 cases (2.6%), 1072 cases (30.8%) and 59 cases (1.7%), respectively. A significantly higher incidence of high-, rather than low-risk HPV infections was found in all age groups (p<0.001). Also, in this high-risk population with positive screening a significant decrease was detected in the prevalence of both high- and low-risk infections beyond 35 years of age (p<0.001). However, the decline in the HR-HPV types occurred later than in the case of LR infections, and HR-HPV was of remarkable frequency in the older age groups, which might represent both incidental and prevalent cases. Subgroup analysis for estimating monthly clearance rates revealed no significant differences between the various age groups and between women with various cytology results. CONCLUSIONS: In a population with positive cytology the prevalence of HPV drops with age while the relative frequency of high-risk HPV infection remains at the same level as that of the youngest age group.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
humán papillomavírus
Megjelenés:European Journal of Obstetrics and Gynecology and Reproductive Biology 138 : 2 (2008), p. 194-198. -
További szerzők:Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Huga Sándor (1965-) (szülész-nőgyógyász szakorvos) Hernádi Zoltán (1948-) (szülész-nőgyógyász, klinikai onkológus)
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