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001-es BibID:	BIBFORM056876
Első szerző:	Asztalos, Elizabeth V.
Cím:	Multiple courses of antenatal corticosteroids for preterm birth study : 2-year outcomes / Elizabeth V. Asztalos, Kellie E. Murphy, Mary E. Hannah, Andrew R. Willan, Stephen G. Matthews, Arne Ohlsson, Edmond N. Kelly, Saroj Saigal, Susan Ross, Marie-France Delisle, Kofi Amankwah, Patricia Guselle, Amiram Gafni, Shoo K. Lee, B. Anthony Armson, Renee Sananes, Laura Tomat, Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group
Dátum:	2010
ISSN:	0031-4005
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pediatrics. - 126 : 5 (2010), p. e1045-e1055. -
További szerzők:	Murphy, Kellie E. Hannah, Mary E. Willan, Andrew R. Matthews, Stephen G. Ohlsson, Arne Kelly, Edmond N. Saigal, Saroj Ross, Susan Delisle, Marie-France Amankwah, Kofi Guselle, Patricia Gafni, Amiram Lee, Shoo K. Armson, B. Anthony Sananes, Renee Tomat, Laura Polonkai Edit (1965-) (csecsemő és gyermekgyógyász, neonatológus) Major Tamás (1963-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Bartha Tünde Zsadányi Judit Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM076773
Első szerző:	Murphy, Kellie E.
Cím:	Effect of Antenatal Corticosteroids on Fetal Growth and Gestational Age at Birth / Kellie E. Murphy, Andrew R. Willan, Mary E. Hannah, Arne Ohlsson, Edmond N. Kelly, Stephen G. Matthews, Saroj Saigal, Elizabeth Asztalos, Susan Ross, Marie-France Delisle, Kofi Amankwah, Patricia Guselle, Amiram Gafni, Shoo K. Lee, B. Anthony Armson, Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group
Dátum:	2012
ISSN:	0029-7844
Megjegyzések:	To estimate the effect of multiple courses of antenatal corticosteroids on neonatal size, controlling for gestational age at birth and other confounders, and to determine whether there was a dose-response relationship between number of courses of antenatal corticosteroids and neonatal size. METHODS: This is a secondary analysis of the Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study, a double-blind randomized controlled trial of single compared with multiple courses of antenatal corticosteroids in women at risk for preterm birth and in which fetuses administered multiple courses of antenatal corticosteroids weighed less, were shorter, and had smaller head circumferences at birth. All women (n=1,858) and children (n=2,304) enrolled in the Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study were included in the current analysis. Multiple linear regression analyses were undertaken. RESULTS: Compared with placebo, neonates in the antenatal corticosteroids group were born earlier (estimated difference and confidence interval [CI]: -0.428 weeks, CI -0.10264 to -0.75336; P=.01). Controlling for gestational age at birth and confounding factors, multiple courses of antenatal corticosteroids were associated with a decrease in birth weight (-33.50 g, CI -66.27120 to -0.72880; P=.045), length (-0.339 cm, CI -0.6212 to -0.05676]; P=.019), and head circumference (-0.296 cm, -0.45672 to -0.13528; P<.001). For each additional course of antenatal corticosteroids, there was a trend toward an incremental decrease in birth weight, length, and head circumference. CONCLUSION: Fetuses exposed to multiple courses of antenatal corticosteroids were smaller at birth. The reduction in size was partially attributed to being born at an earlier gestational age but also was attributed to decreased fetal growth. Finally, a dose-response relationship exists between the number of corticosteroid courses and a decrease in fetal growth. The long-term effect of these findings is unknown.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Obstetrics and Gynecology. - 119 : 5 (2012), p. 917-923. -
További szerzők:	Willan, Andrew R. Hannah, Mary E. Ohlsson, Arne Kelly, Edmond N. Matthews, Stephen G. Saigal, Saroj Asztalos, Elizabeth V. Ross, Susan Delisle, Marie-France Amankwah, Kofi Guselle, Patricia Gafni, Amiram Lee, Shoo K. Armson, B. Anthony Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM076772
Első szerző:	Murphy, Kellie E.
Cím:	Maternal side-effects after multiple courses of antenatal corticosteroids (MACS) : the three-month follow-up of women in the randomized controlled trial of MACS for preterm birth study / Kellie E. Murphy, Mary E. Hannah, Andrew R. Willan, Arne Ohlsson, Edmond N. Kelly, Stephen G. Matthews, Saroj Saigal, Elizabeth Asztalos, Sue Ross, Marie-France Delisle, Laura Tomat, Kofi Amankwah, Patricia Guselle, Amiram Gafni, Shoo K. Lee, B. Anthony Armson, MACS Collaborative Group
Dátum:	2011
ISSN:	2212-0971
Megjegyzések:	OBJECTIVE: A single course of antenatal corticosteroids (ACS) is associated with a reduction in respiratory distress syndrome and neonatal death. Multiple Courses of Antenatal Corticosteroids Study (MACS), a study involving 1858 women, was a multicentre randomized placebo-controlled trial of multiple courses of ACS, given every 14 days until 33+6 weeks or birth, whichever came first. The primary outcome of the study, a composite of neonatal mortality and morbidity, was similar for the multiple ACS and placebo groups (12.9% vs. 12.5%), but infants exposed to multiple courses of ACS weighed less, were shorter, and had smaller head circumferences. Thus for women who remain at increased risk of preterm birth, multiple courses of ACS (every 14 days) are not recommended. Chronic use of corticosteroids is associated with numerous side effects including weight gain and depression. The aim of this postpartum assessment was to ascertain if multiple courses of ACS were associated with maternal side effects. METHODS: Three months postpartum, women who participated in MACS were asked to complete a structured questionnaire that asked about maternal side effects of corticosteroid use during MACS and included the Edinburgh Postnatal Depression Scale. Women were also asked to evaluate their study participation. RESULTS: Of the 1858 women randomized, 1712 (92.1%) completed the postpartum questionnaire. There were no significant differences in the risk of maternal side effects between the two groups. Large numbers of women met the criteria for postpartum depression (14.1% in the ACS vs. 16.0% in the placebo group). Most women (94.1%) responded that they would participate in the trial again. CONCLUSION: In pregnancy, corticosteroids are given to women for fetal lung maturation and for the treatment of various maternal diseases. In this international multicentre randomized controlled trial, multiple courses of ACS (every 14 days) were not associated with maternal side effects, and the majority of women responded that they would participate in such a study again.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of obstetrics and gynaecology Canada. - 33 : 9 (2011), p. 909-921. -
További szerzők:	Hannah, Mary E. Willan, Andrew R. Ohlsson, Arne Kelly, Edmond N. Matthews, Stephen G. Saigal, Saroj Asztalos, Elizabeth V. Ross, Susan Delisle, Marie-France Tomat, Laura Amankwah, Kofi Guselle, Patricia Gafni, Amiram Lee, Shoo K. Armson, B. Anthony Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) MACS Collaborative Group
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM076771
Első szerző:	Murphy, Kellie E.
Cím:	Multiple courses of antenatal corticosteroids for preterm birth (MACS) : a randomised controlled trial / Kellie E. Murphy, Mary E. Hannah, Andrew R. Willan, Sheila A. Hewson, Arne Ohlsson, Edmond N. Kelly, Stephen G. Matthews, Saroj Saigal, Elizabeth Asztalos, Susan Ross, Marie-France Delisle, Kofi Amankwah, Patricia Guselle, Amiram Gafni, Shoo K. Lee, B. Anthony Armson, MACS Collaborative Group
Dátum:	2008
ISSN:	0140-6736
Megjegyzések:	One course of antenatal corticosteroids reduces the risk of respiratory distress syndrome and neonatal death. Weekly doses given to women who remain undelivered after a single course may have benefits (less respiratory morbidity) or cause harm (reduced growth in utero). We aimed to find out whether multiple courses of antenatal corticosteroids would reduce neonatal morbidity and mortality without adversely affecting fetal growth. METHODS: 1858 women at 25-32 weeks' gestation who remained undelivered 14-21 days after an initial course of antenatal corticosteroids and continued to be at high risk of preterm birth were randomly assigned to multiple courses of antenatal corticosteroids (n=937) or placebo (n=921), every 14 days until week 33 or delivery, whichever came first. The primary outcome was a composite of perinatal or neonatal mortality, severe respiratory distress syndrome, intraventricular haemorrhage (grade III or IV), periventricular leucomalacia, bronchopulmonary dysplasia, or necrotising enterocolitis. Analysis was by intention to treat. All patients and caregivers were unaware of the treatment given. This trial is registered as number ISRCTN2654148. FINDINGS: Infants exposed to multiple courses of antenatal corticosteroids had similar morbidity and mortality to those exposed to placebo (150 [12.9%] vs 143 [12.5%]). Those receiving multiple doses of corticosteroids also weighed less at birth than those exposed to placebo (2216 g vs 2330 g, p=0.0026), were shorter (44.5 cm vs 45.4 cm, p<0.001), and had a smaller head circumference (31.1 cm vs 31.7 cm, p<0.001). INTERPRETATION: Multiple courses of antenatal corticosteroids, every 14 days, do not improve preterm-birth outcomes, and are associated with a decreased weight, length, and head circumference at birth. Therefore, this treatment schedule is not recommended.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Lancet. - 372 : 9656 (2008), p. 2143-2151. -
További szerzők:	Hannah, Mary E. Willan, Andrew R. Hewson, Sheila A. Ohlsson, Arne Kelly, Edmond N. Matthews, Stephen G. Saigal, Saroj Asztalos, Elizabeth V. Ross, Susan Delisle, Marie-France Amankwah, Kofi Guselle, Patricia Gafni, Amiram Lee, Shoo K. Armson, B. Anthony Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) MACS Collaborative Group
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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