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1.

001-es BibID:BIBFORM117652
Első szerző:Krasznai Zoárd Tibor (szülész-nőgyógyász, gyermeknőgyógyász)
Cím:Az elmúlt tíz év legfontosabb fejlődési irányai a szülészet-nőgyógyászatban / Krasznai Zoárd Tibor, Deli Tamás, Jakab Attila, Lampé Rudolf, Török Péter, Kozma Bence, Molnár Szabolcs
Dátum:2023
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Orvostovábbképző Szemle. - 30 : 7 (2023), p. 89-104. -
További szerzők:Deli Tamás (1979-) (szülész-nőgyógyász, endokrinológus szakorvos) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Lampé Rudolf (1983-) (szülész-nőgyógyász) Török Péter (1975-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász) Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos)
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2.

001-es BibID:BIBFORM078274
Első szerző:Lőrincz Judit (általános orvos)
Cím:The effect of localization and histological verification of endometrial polyps on infertility / Judit Lőrincz, Szabolcs Molnár, Attila Jakab, Tünde Herman, Singh Jashanjeet, Péter Török
Dátum:2019
ISSN:0932-0067 1432-0711
Megjegyzések:Aim Our purpose is to investigate if transcervical resection of endometrial polyps improves the fertility in ovulatory infertile women, and whether polyp histology, intrauterine location, and the technique of polypectomy have any influence on the pregnancy rates. Methods In this retrospective study, clinical data of 87 ovulatory infertile women who underwent hysteroscopy and pol- ypectomy, and their 12-month follow-up have been analyzed. Subgroups according to the method of polyp removal (resec- toscope or curettage), the polyp localization (utero-tubal, anterior, posterior, lateral, multiple) and the histological result were interpreted. Results Meanageofpatientswas33.99?4.24years.TherewerenodifferencesintheBMIandbasalFSHlevelsbetweenthe subgroups. Pregnancy was recorded in 30 (34.5%) within the next 12 months without any difference between the subgroups of polypectomy method applied. Posterior wall polyp resection increased the pregnancy chance (OR 5.02), but no other dif- ferences were observed in 1-year pregnancy rates to other localizations. Removal of polyps which had normal endometrial histology had lower pregnancy rates as compared to that of polyps with hyperplasia or endometrial polyp histology results (OR 0.25). Conclusions Polypectomy improved the conception rate in the subsequent year regardless of the intrauterine localization and the method of its surgical removal. Therefore, we can conclude that polypectomy should be considered in infertile women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
endometrium polyp
infertilitás
hiszteroskópia
reprodukció
Megjelenés:Archives of Gynecology and Obstetrics. - 300 : 1 (2019), p. 217-221. -
További szerzők:Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Herman Tünde (1979-) (orvos) Singh, Jashanjeet (1976-) (szülész-nőgyógyász szakorvos) Török Péter (1975-) (szülész-nőgyógyász)
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3.

001-es BibID:BIBFORM086962
Első szerző:Molnár Szabolcs (szülész-nőgyógyász szakorvos)
Cím:Effectiveness of different methods for polypectomy in the menopause : a retrospective study / Szabolcs Molnár, Zsolt Farkas, Attila Jakab, Rudolf Lampé, Péter Török
Dátum:2020
ISSN:1369-7137
Megjegyzések:Introduction: Most endometrial polyps represent focal hyperplasia of the endometrium. Endometrial polyps can be diagnosed by ultrasound, hysterocontrast sonography, hysterosalpingography, endometrial biopsy, and uterine curettage, but diagnostic hysteroscopy is considered the gold-standard method, with the greatest sensitivity and specificity and also with the opportunity for treatment at the same time. Study design: A retrospective study was conducted on 424 patients between 2006 and 2018. The polyps were verified during diagnostic hysteroscopy and were removed by resectoscopy or curettage. All samples underwent histological examination. The effectivity of the type of resection and the recurrence rate were evaluated. Results: The average age of the patients was 60.2???9.3?years. Polyps were excised in 62.97% by resectoscopic polypectomy and in 37.03% by curettage. Malignancy was confirmed in 4.24% of cases. Histological verification of polyps was 79.4% in the resectoscopy group and 69.04% in the curettage group; the difference was significant (p?<?0.01). The recurrence rate was 20.47% after resectoscopy and 27.12% following curettage. Conclusion: Hysteroscopy remains the best option and the gold-standard method among diagnostic procedures of endometrial pathology. In this study, there was a significant difference in matching hysteroscopic and histological findings in the two methods of polypectomy. The recurrence rate is also lower following resectoscopy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
endometrial polyp
hysteroscopy
resectoscope
curettage
recurrence
abnormal uterine bleeding
Megjelenés:Climacteric. - 23 : 4 (2020), p. 325-329. -
További szerzők:Farkas Zsolt (1987-) (szülész-nőgyógyász) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Lampé Rudolf (1983-) (szülész-nőgyógyász) Török Péter (1975-) (szülész-nőgyógyász)
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4.

001-es BibID:BIBFORM061574
Első szerző:Molnár Szabolcs (szülész-nőgyógyász szakorvos)
Cím:Effect of endometrial polyps, histology, intrauterine localization and the technique of polypectomy On Fertility / Molnar S., Torok P., Juhasz A. G., id. Orosz L., Jakab A.
Dátum:2015
Megjegyzések:BackgroundEndometrial polyps are frequently found in infertile patients, but most of them are asymptomatic. They can be effectively detected by ultrasound using contrast media or color Doppler, but the gold standard is hysteroscopy. In reproductive age, they carry low risk of malignancy. It is assumed that larger polyps hamper implantation. However, it is not clear yet, whether resection of all polyps necessarily improves the fertility, and is the polyp localization influence the implantation failure.MethodsA retrospective study of ovulatory infertile women with endometrial polyp, at whom TCRP was performed between 2006 and 2012. Time interval between operation and the first pregnancy were registered, if pregnancy occured until 2014. The aim was to evaluate whether the transcervical resection of endometrial polyps (TCRP) improves the fertility status, and polyp histology, intrauterine location, the technique of polypectomy have influence of pregnancy rate (PR) in ovulatory infertile women.ResultsFifty patients were eligible for data collection. Anovulation, tubal, male factor were excluded. TCRP was performed by resectoscop or hysteroscopically controlled curettage, hystology was examined. Polyps were categorized to localization: utero-tubal junction, anterior, posterior, lateral, multiple. PR was calculated to TCRP method, histology and location. T-test was used for differences. Twenty-seven pregnancies (54%) were registered after TCRP, 20 (40%) of them in one year. Mean time interval until conception was 12,1 (range 3-41) months. PR was similar in resectoscop and curettage group (21/37, 56% vs. 6/13, 46%). To histology, PR was higher if simple polyp was found than after polyps with hyperplasia (24/37, 65% vs. 3/13, 23%, P=0.008). There were no differences in PR, neither in time interval to conception between the groups of different polyplocalisation.ConclusionsRemoving of endometrial polyps by TCRP improves the fertility of ovulatory women, irrespective to the resection method, i.e. resectoscop or hysteroscopy controlled curettage. Pregnancy rate is higher if endometrial hyperplasia is not found in the polyp. The location of endometrial polyp in the uterine cavity does not influence the fertility. Our data supports the hypothesis, that endometrial polyps physically prevent the implantation and can be the single cause of infertility. Thus, TCRP is recommended, irrespective to polyp localization. Resectoscopy is not superior than histeroscopically controlled curettage. Fertility prognosis is worse if hyperplasia is present, otherwise the one-year PR is good. Although the minimum follow up was 2 years, longer postoperative follow and larger patients number may alter the pregnacy rates. Influence of polyp size was not examined. Fertility related life-style and enviromental factors were not examined.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Endometrium
Infertility
polypectomy
hysteroscopy
Megjelenés:Gynecological Surgery. - 12 : Suppl1 (2015), p. S315 -
További szerzők:Török Péter (1975-) (szülész-nőgyógyász) Juhász Alpár Gábor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) id. Orosz László Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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5.

001-es BibID:BIBFORM087915
Első szerző:Török Péter (szülész-nőgyógyász)
Cím:Preoperative assessment of endometrial cancer / Péter Török, Zoárd Krasznai, Szabolcs Molnár, Rudolf Lampé, Attila Jakab
Dátum:2020
ISSN:2218-676X 2219-6803
Megjegyzések:Endometrial cancer (EC), the most common among gynaecological malignancies occurs predominantly after the menopause. The diagnosis is most commonly (in about 75?80%) set up at early stage when surgical therapy and if necessary postoperative radiotherapy results in an excellent prognosis, with a 90?95% 5-year overall survival (OS) and a locoregional recurrence rates of 4?8%. Accurate preoperative assessment of the lymph nodes would ideally identify those patients with advanced stage disease, who might benefit from more extensive surgical procedures and adjuvant therapies. magnetic resonance imaging (MRI), hysteroscopic excisional biopsy (HEB) and high resolution 2D or 3D ultrasound performed by expert operator are considered to add valuable information for preoperative staging of EC. The use of biomarkers could be beneficial in decreasing inter-observer variability between the histology of the diagnostic specimen and the final operative sample, as well as to avoid overtreatment in a part of the high-grade tumors with excellent prognosis. The goal of surgical management of EC is to remove the primary tumor and to identify definite prognostic factors to determine whether adjuvant therapy is required. Extended surgery, including para-aortic lymphadenectomy has a significant morbidity, and with the future selection of cases it can be safely avoided, we can decrease complications without compromising oncological safety. In the future, the importance of hysteroscopy guided sampling may increase to gain a representative sample for biomarker detection.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
endometrial cancer
hysteroscopy
magnetic resonance imaging
staging
ultrasound
Megjelenés:Translational Cancer Research. - 9 : 12 (2020), p. 7746-7758. -
További szerzők:Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Lampé Rudolf (1983-) (szülész-nőgyógyász) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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6.

001-es BibID:BIBFORM086961
Első szerző:Török Péter (szülész-nőgyógyász)
Cím:The use of hysteroscopy in endometrial cancer : old questions and novel challenges / Péter Török, Szabolcs Molnár, Rudolf Lampé, Attila Jakab
Dátum:2020
ISSN:1369-7137
Megjegyzések:Endometrial cancer is the most common gynecological malignancy with a relatively good overall prognosis. It traditionally has two subtypes: type 1 (endometrioid carcinoma) and type 2 (non-endometrioid carcinoma). The prognosis is excellent for stage I endometrioid cancer, with a 5-year survival rate of 96%. However, the prognosis is much worse for women with high-risk endometrial cancer. Effective preoperative staging is important in order to tailor treatment and achieve optimal long-term survival. The majority of asymptomatic polyps detected by ultrasound are treated surgically. Conventionally, dilatation and curettage was performed to obtain a histological diagnosis, but nowadays hysteroscopy with biopsy is starting to be considered as the gold standard. Hysteroscopic resection seems to reduce the risk of underdiagnosed (atypical endometrial hyperplasia) endometrial cancer. To avoid the spread of malignant cells, hysteroscopy should be performed with concern to keep intrauterine pressure low. In comparison with cervical injection, the hysteroscopic method has a better detection rate in the para-aortic area during sentinel lymph node mapping. In the assessment of cervical involvement, the accuracy of magnetic resonance imaging is significantly higher than the accuracy of hysteroscopy. In fertility-sparing cases, hysteroscopic endometrium resection with progesterone therapy is an acceptable option.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
endometrial cancer
hysteroscopy
MRI
curettage
ultrasound
staging
Megjelenés:Climacteric. - 23 : 4 (2020), p. 330-335. -
További szerzők:Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Lampé Rudolf (1983-) (szülész-nőgyógyász) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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