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001-es BibID:	BIBFORM117861
Első szerző:	Herman Tünde (orvos)
Cím:	Hashimoto's thyroiditis negatively influences ICSI outcome in euthyroid women on T4 substitution therapy; a retrospective study / Tünde Herman, Péter Török, Antonio Simone Laganà, Vito Chiantera, Renato Venezia, Attila Jakab
Dátum:	2024
ISSN:	0378-7346
Megjegyzések:	Abstract Objective: To analyze the impact of thyroid autoimmunity (TAI) on reproductive outcome parameters of ICSI cycles as compared to TAI negative ICSI cycles. Design: In this single IVF center retrospective study 86 infertile women with elevated TPOAb or TGAb levels, but euthyroid after thyroxine replacement (study group), were compared to 69 female patients with no thyroid abnormalities (controls). Following ICSI treatment fertilization rate (FR), clinical pregnancy rate (CPR), miscarriage rate (MR) and live birth rate (LBR) were analyzed. Materials, Setting, Methods: All subjects with various infertility factors were treated with ICSI in university based IVF center. Patients in the study group received thryroxine replacement and were euthyreoid at IVF treatment. Before the IVF cycles endocrinological parameters were uniformly assessed: thyroid function and antibodies, reproductive hormones (AMH, FSH, LH, E2, PRL, testosterone, DHEAS, 17-OHP, AD) and OGTT (0-60-120 min glucose and insulin). Following descriptive comparison of laboratory parameters, age adjusted analyses of FR, CPR, MR and LBR were performed. Results: TAI positive women were older (mean age 35.31?4.95 vs. 32.15?4.87 years; p=0.002), had higher FSH (8.4?3.4 vs. 7.4?2.32 U/L; p=0.024), higher E2 (53.94?47.61 vs. 42.93?18.92 pg/ml; p=0.025) levels, while AMH (2.88?2.62 vs. 3.61?1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64?0.96 vs. 1.66?0.65 uIU/ml; p=0.652) between the two groups. FT3 (2.63?0.58 vs. 2.98?0.55 pg/ml; p=0.002) was lower and FT4 (1.3?0.29 vs. 1.13?0.21 ng/dl; p=0.0002) was higher in the TAI positive group, reflecting clinically irrevelant differences. Egg cell counts (6?3.8 vs. 7.5?3.95; p=0.015) were lower in TAI and remained so following age adjustment. Although the overall ICSI FR did not differ (62.9 % vs. 69.1 %, p=0.12), it was lower for patients under 35 with TAI showing decreasing differences in line with age. The CPR (36.04 % vs. 69.56 %; p<0.001), LBR (23.25 % vs. 60.86 %; p<0.001) were lower, the MR (35.48 % vs. 12.5 %; p=0.024) was higher in the TAI group and these differences remained after age adjustment. Limitations: Since the higher age of the study group may interfere with the effect of TAI, age adjustment calculations were necessary to perform to eliminate this confounding factor. Conclusion: Despite optimal thyroid supplementation in clinical or subclinical hypothyreoidism, the presence of TAI negatively influences clinical pregnancy rate and is connected to a higher miscarriage rate, thus resulting in a lower live birth rate after ICSI. Decreased fertilization rate with ICSI in TAI patients may also contribute to poorer outcomes, especially in younger women.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk IVF ICSI Hashimoto thyreoiditis
Megjelenés:	Gynecologic And Obstetric Investigation. - [Epub ahead of print] (2024). -
További szerzők:	Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Venezia, Renato Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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001-es BibID:	BIBFORM105360
035-os BibID:	(WoS)000894986300001 (Scopus)85143521697
Első szerző:	Herman Tünde (orvos)
Cím:	Impact of endocrine disorders on IVF outcomes : results from a large, single-centre, prospective study / T. Herman, Sz. Csehely, M. Orosz, H. P. Bhattoa, T. Deli, P. Török, A. S. Laganà, V. Chiantera, A. Jakab
Dátum:	2023
ISSN:	2045-2322
Megjegyzések:	Endocrine disorders negatively influence the ovarian function and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders the laboratory parameters were corrected before IVF treatment. 161 patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32,5%), diminished ovarian reserve (23,8%), insulin resistance (22,5%), PCOS (15,2%), hyperprolactinemia (13,4%), obesity (12,1%), hypogonadotropic hypogonadism (0,8%), congenital adrenal hyperplasia (0.2%). Before the IVF treatment systematic endocrine laboratory examinations were performed in all patients. Higher age, BMI, and FSH was found in the study group, while AMH level was lower. There were no differences in LH, E2, prolactin, TSH, FT3, FT4, TT, DHEAS, androstendione, 17-OHP, SHBG level between the study and control groups. The study group had higher baseline glucose, baseline insulin, 120 minute glucose and 120 minute insulin level after oral glucose tolerance test. With no difference in the IVF cycles performed, pregnancy rate was lower in the study group (61.43 % vs. 34.16 %; p=0.003), and this difference (p=0.0151) remained in age-corrected rates, as well. The analysis were also performed in individual endocrinology groups. The prevalence of endocrine disorders is high in females participating in IVF programs and they often accompanying to each other. Even after proper correction, the presence of the endocrine disorder negatively influences the pregnancy rate in IVF treatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk assisted reproduction in vitro fertilization endocrine diseases thyroid diseases
Megjelenés:	Reproductive Sciences. - 30 : 6 (2023), p. 1878-1890. -
További szerzők:	Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Orosz Mónika (1991-) (Szülész-nőgyógyász) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Deli Tamás Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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001-es BibID:	BIBFORM088442
Első szerző:	Herman Tünde (orvos)
Cím:	In Vitro Fertilization Treatment of a Patient with Primary Partial Empty Sella and Other Co-Factors / Tünde Herman, Péter Török, Antonio Simone Laganȧ, Attila Jakab
Dátum:	2020
ISSN:	2377-9004
Megjegyzések:	We report the case of a patient with primary empty sella, who had successful assisted reproductive treatment. The patient is a 28-years-old infertile female with primary amenorrhoea and hypogonadotropic hypogonadism. Serum FSH, LH, E2 indicated central anovulation, but the production of GH, ACTH, TSH and PRL were normal. Obesity and insulin resistance were present. Male partner had asthenozoo-teratospermia and hyperprolactinaemia. After three failed intrauterine inseminations, she was addressed to gynecologic endocrinology where cerebral MRI was done, which revealed partial empty sella. Due to the combination of several infertility factors, the couple was referred for IVF. Since the initial fertilization rate was low at IVF-ICSI and implantation failed, intensive lifestyle modification and endocrinological care was introduced for 5 months, then the second IVF treatment was effective and, after a relatively uneventful pregnancy, healthy twin boys were born near-term.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Hypogonadotropic hypogonadism (HH) Primary empty sella (PES) Astheno-teratozoospermia (AT) In vitro fertilization (IVF)
Megjelenés:	Obstetrics and Gynaecology Cases - Reviews. - 7 : 5 (2020), p. 1-6. -
További szerzők:	Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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001-es BibID:	BIBFORM101455
035-os BibID:	(cikkazonosító)970 (WoS)000786981800001 (Scopus)85128843077
Első szerző:	Szegeczki Vince
Cím:	Endometrium as Control of Endometriosis in Experimental Research : assessment of Sample Suitability / Szegeczki Vince, Fazekas László, Kulcsár Máté, Reglodi Dora, Török Péter, Orlik Brigitta, Lagana Antonio Simone, Jakab Attila, Juhasz Tamas
Dátum:	2022
ISSN:	2075-4418
Megjegyzések:	Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected women. Revealing alterations of the molecular processes in ectopic endometrial tissue is the current policy for understanding the pathomechanisms and discovering potential novel thera- peutic targets. Examining molecular processes of eutopic endometrium is likely to be a convenient method to compare it with the molecular alterations observed in ectopic tissues. The aim of the present study was to determine what proportion of the surgically resected eutopic endometrial samples is suitable for further experiments so that these can be comparable with endometriosis. Final hospital reports and histopathology reports of a 3-year-long period (1162 cases) were ana- lysed. The application of a retrospective screening method promoted the categorization of these cases, and quantification of the categorized cases was accomplished. In addition, results obtained from cultured endometrium samples were also detailed. Only a small number of the harvested en- dometrial samples was suitable for further molecular analysis, while preoperative screening proto- col could enlarge this fraction. Applying clinical and histopathological selection and exclusion cri- teria for tissue screening and histopathological examination of samples could ensure the compara- bility of healthy endometrium with endometriosis. The present study could be useful for research- ers who intend to perform molecular experiments to compare endometriosis with the physiological processes of the endometrium.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk endometrium curettage hysteroscopy endometrial sampling in vitro endometrial culturing
Megjelenés:	Diagnostics. - 12 : 4 (2022), p. 1-17. -
További szerzők:	Fazekas László Kulcsár Máté Reglődi Dóra (Idegtudományok) Török Péter (1975-) (szülész-nőgyógyász) Orlik Brigitta Laganà, Antonio Simone Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Juhász Tamás (1976-) (biológus, orvosbiológus)
Pályázati támogatás:	ÚNKP-17-2 Egyéb ÚNKP-19-3 Egyéb ÚNKP-20-3-II Egyéb EFOP-3.6.3-VEKOP-16-2017-00009 EFOP NKFIHK139396 Egyéb MTA-TKI 14016 Egyéb
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