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001-es BibID:BIBFORM078517
Első szerző:Takács Péter
Cím:Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms : a Pilot Study / Peter Takacs, Bence Kozma, Balazs Erdodi, Attila Jakab, Kindra Larson, Robert Poka
Dátum:2019
ISSN:2288-6478 2288-6761
Megjegyzések:Objectives: Although vaginal estrogen is highly effective in alleviating genitourinary symptoms of menopause (GSM), some women are reluctant to use hormonal treatment. Our aim was to evaluate the effect of a zinc-containing vaginal moisturizer gel on GSM. Methods: Women with GSM were enrolled. Patients were asked to use the vaginal gel daily for 2 weeks. Vaginal Health Index (VHI) was calculated. Visual analogue scale (VAS) was obtained on vaginal pain, dryness, burning, itching, dyspareunia and dysuria before and 2 weeks after the completion of treatment. Vaginal cytology was obtained. Vulvovaginal symptom questionnaire (VSQ-21) was used to assess subjective symptoms. Results: Thirty-seven women with GSM participated in the study. The VHI improved significantly (mean ? standard deviation, 13 ? 4 before vs. 17 ? 4 after treatment, P < 0.01). The patient reported VAS combined score was significantly lower after the treatment (18 ? 14 before vs. 7 ? 12 after treatment, P < 0.01). The largest improvement occurred in vaginal dryness. The maturation value did not change significantly. There were no signs of inflammation on vaginal cytology. VSQ-21 combined scores also improved significantly (7.9 ? 5.5 before vs. 2.7 ? 3.6 after the intervention, P < 0.01). Side effects were rare and minor. Conclusions: Novel zinc-containing vaginal moisturizer gel significantly improves postmenopausal vulvovaginal symptoms without serious side effects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Zinc
Vagina
Menopause
Megjelenés:Journal of Menopausal Medicine. - 25 : 1 (2019), p. 63-68. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Erdődi Balázs (1984-) (szülész-nőgyógyász szakorvosjelölt) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Larson, Kindra Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
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