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001-es BibID:BIBFORM019887
Első szerző:Orosz László (szülész-nőgyógyász)
Cím:Long-term Outcome of Pregnancies with Increased Nuchal Translucency and Normal Karyotype / L. Orosz, J. Lukács, M. Szabó, T. Kovács, I. Zsupán, G. Orosz, Z. Tóth, O. Török
Dátum:2009
Megjegyzések:The aim of this study was to examine the prevalence of major and minor anomalies according to the increase of NT thickness.Methods: This is a long-term retrospective study in which singleton gestations of euploid fetuses with increased NT were analyzed. NT measurement was performed in the first trimester examination according to the criteria of Fetal Medicine Foundation (FMF) when the fetal crown-rump length (CRL) was 45 to 84 mm. The cases were followed up from 1 to 5 years postpartum to assess the presence of CHD and to point out other anomalies that could be associated with increased NT.Results: The outcome of 133 cases could be analysed out of 198 pregnancies of which in 55 cases some congenital anomalies (minor or major) were revealed up to the 5 years of life (prevalence of 41.4%). The prevalence of CHDs, including the defects of the great vessels, stood out among the others. In the group with NT between 95th and 99th centiles four cases with minor heart problems wereidentified (11.1%, 4/36). The rate of major cardiac defects proved to be 13.3% (6/45) in the group with NT between 3.5-4.4 mm, and 17.3% (9/52) in the group with NT > 4.5 mm. Among the 35 healthy children with various minor health problems not related to the presence of increased nuchal translucency there were 7 cases with hydrocele. In 3 of them it was associated with unilateral inguinalhernia but in 3 it was isolated and one was part of a complex malformation (The rate of other organ-specific anomalies did not prove to be significant). In the whole study population only thirteen cases (9.8%) ended up in intrauterine death, or arteficial abortion.Conclusion: The prevalence of major cardiac defects as well as other major anomalies increases with fetal nuchal thickness. Since the prevalence of CHD is 100 times higher in the population of fetuses with NT above 4.5 mm, specialist fetal echocardiography should be offered in the second trimester together with other follow-up investigations. Among the children without any major abnormalities, a high number of minor anomalies were revealed during the long-term follow-up. These anomalies do not have significant disadvantage to the quality of life, but some of them necessitates short or long-term medical treatment and this should also be leveled with the future parents. Despite the numerous investigations the exact etiology of increased NT remains unknown. The relatively high prevalence of hydrocele in the newborns in our material raises the question wheather it is related to the presence of NT in the fetal period because of abnormallymphatic development or alterations in the extracellular matrix. Further long-term follow-up studies could probably contribute to find explanation on the etiology of increased NT in the first trimester. These data can be used when counseling parents of euploid fetuses with increased fetal NT.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Congenital heart defects
fetal echocardiography
nuchal translucency
hydrocele
first trimester screening
long-term follow-up
Megjelenés:Donald School Journal of Ultrasound in Obstetrics and Gynecology. - 3 : 3 (2009), p. 53-59. -
További szerzők:Lukács János (1975-) (szülész-nőgyógyász, genetikus) Szabó Mária (1954-) (vegyész) Kovács Tamás (1959-) (szülész-nőgyógyász, humángenetikus) Zsupán Ildikó (biológus) Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM031457
Első szerző:Papp Zoltán (szülész-nőgyógyász, genetikus)
Cím:Impact of prenatal mid-trimester screening on the prevalence of fetal structural anomalies : a prospective epidemiological study / Z. Papp, E. Tóth-Pál, Cs. Papp, Z. Tóth, M. Szabó, L. Veress, O. Török
Dátum:1995
ISSN:0960-7692
Megjegyzések:The objective of this study was to evaluate the effectiveness of the measurement of maternal serum alpha-fetoprotein (MSAFP) at 16 weeks and a subsequent routine ultrasound screening at 18-20 weeks' gestation and the impact on the birth prevalence of congenital structural anomalies in an unselected pregnant population of Hungary in a prospective epidemiological study. A total of 63,794 pregnant women (representing one-sixth of the population of Hungary) were offered this screening program over 3 years (1988-90). Of the pregnant population, 75.7% (48,312) received MSAFP screening and in 81.0% (51,675), at least one ultrasound scan was performed. In the screened pregnancies, 496 craniospinal, thoraco-abdominal, urogenital and other severe major anomalies occurred; 317 were detected at 18-20 weeks (sensitivity 63.1%; specificity 100.0%; positive predictive value 100.0%). The sensitivity of ultrasound scanning was significantly higher (p < 0.05) than that of the MSAFP screening. (At the time of ultrasound scanning the MSAFP value was known.) In this study, the less serious anomalies such as hydrocele, hypospadias and undescended testicle were not systematically searched for, but the birth prevalences were calculated. The overall mid-trimester prevalence of severe plus less severe major anomalies was 2.26%. The birth prevalences of severe major anomalies were 0.57 (craniospinal), 4.36 (thoracoabdominal and urogenital) and 1.21 (other severe) per 1000. These values were lower than the mid-trimester prevalences which were 2.94, 5.20 and 2.06 per 1000, respectively. The prevalence values at the age of 1 year were also calculated (0.36, 2.21, 0.54 per 1000, respectively). We conclude that our screening program with availability of termination of pregnancy could significantly (p < 0.05) reduce the prevalence of severe major abnormalities at birth. Training programs in cardiac scanning are required.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Impact of prenatal
prevalence of fetal
egyetemen (Magyarországon) készült közlemény
Megjelenés:Ultrasound in Obstetrics and Gynecology. - 6 : 5 (1995), p. 320-326. -
További szerzők:Tóth-Pál Ernő (nőgyógyász) Papp Csaba (szülész-nőgyógyász) Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Szabó Mária (1954-) (vegyész) Veress Lajos (1950-) (vegyész) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:bibEBI00018946
Első szerző:Török Olga (szülész-nőgyógyász, humángenetikus)
Cím:Second trimester sonographic markers int he risk calculation of Down syndrome / Török O., Lukács J., Szabó M., Kovács T., Zsupán I., Veress L., Tóth Z.
Dátum:2005
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Ultrasound in Obstetrics and Gynecology. - 26 : 4 (2005), p. 377. -
További szerzők:Lukács János (1975-) (szülész-nőgyógyász, genetikus) Szabó Mária (1954-) (vegyész) Kovács Tamás (1959-) (szülész-nőgyógyász, humángenetikus) Zsupán Ildikó (biológus) Veress Lajos (1950-) (vegyész) Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus)
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