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001-es BibID:BIBFORM047593
Első szerző:Benkő Klára
Cím:Effect of Rosiglitazone on Radiation Damage in Bone Marrow Hemopoiesis / Klára Benkő, Éva Pintye, Boglárka Szabó, Krisztina Géresi, Attila Megyeri, Ilona Benkő
Dátum:2008
Megjegyzések:To study radiobiological effects and drugs, which can modify radiation injury, has an importance if we would like to avoid harmful effects of radiation due to emergency situations or treat patients with malignant diseases by radiotherapy. During the long treatment schedules patients may be treated by not only anticancer but many other drugs because of accompanying diseases. These drugs may also modify radiobiological effects. Rosiglitazone pre?treatment proved to be myeloprotective and accelerated recovery of 5?fluorouracil?damaged bone marrow in our previous experiments. Our new studies are designed to evaluate whether rosiglitazone has similar beneficial effects in radiation?damaged hemopoiesis. Bone marrow damage was precipitated by total body irradiation (TBI) using single increasing doses (2?10 Gy) of ??irradiation in groups of mice. Lethality was well correlated with damage in hemopoiesis measured by cellularity of bone marrow (LD50 values were 4.8 and 5.3 gray respectively). Rosiglitazone, an insulin?sensitizing drug, had no significant effect on bone marrow cellularity. Insulin resistance associated with obesity or diabetes mellitus type 2 is intensively growing among cancer patients requiring some kind of radiotherapy. Therefore it is important to know whether drugs used for their therapy can modify radiation effects.
ISBN:978 0 7354 0611 7
Tárgyszavak:Orvostudományok Elméleti orvostudományok előadáskivonat
biological effects of radiation
radiation therapy
Monte Carlo methods
DNA
Megjelenés:Radiation Damage In Biomolecular Systems : Proceedings of the 5th International Conference : AIP Conference Proceedings volume 1080 / szerk. Karoly Tokesi, Bela Sulik. - p. 185-188. -
További szerzők:Pintye Éva (1955-) (fizikus) Szabó Boglárka Géresi Krisztina (1985-) (molekuláris biológus) Megyeri Attila (1968-) (orvos) Benkő Ilona (1954-) (orvos, farmakológus)
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001-es BibID:BIBFORM047594
Első szerző:Röszer Tamás (orvos, biológus)
Cím:Bone Marrow Transplantation in Mice as a Tool to Generate Genetically Modified Animals / Tamás Rőszer, Éva Pintye, Ilona Benkő
Dátum:2008
Megjegyzések:Transgenic mice can be used either as models of known inherited human diseases or can be applied to perform phenotypic tests of genes with unknown function. In some special applications of gene modification we have to create a tissue specific mutation of a given gene. In some cases however the gene modification can be lethal in the intrauterine life, therefore we should engraft the mutated cells in the postnatal life period. After total body irradiation transplantation of bone marrow cells can be a solution to introduce mutant hematopoietic stem cells into a mature animal. Bone marrow transplantation is a useful and novel tool to study the role of hematopoietic cells in the pathogenesis of inflammation, autoimmune syndromes and many metabolic alterations coupled recently to leukocyte functions.
ISBN:978 0 7354 0611 7
Tárgyszavak:Orvostudományok Elméleti orvostudományok előadáskivonat
könyvrészlet
radiation therapy
DNA
radiation effects
molecular biophysics
Megjelenés:Radiation Damage In Biomolecular Systems : Proceedings of the 5th International Conference : AIP Conference Proceedings volume 1080 / szerk. Karoly Tokesi, Bela Sulik. - p. 189-193. -
További szerzők:Pintye Éva (1955-) (fizikus) Benkő Ilona (1954-) (orvos, farmakológus)
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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