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001-es BibID:	BIBFORM035329
Első szerző:	Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:	Bone mineral density, biochemical markers of bone turnover, and hormonal status in men with systemic lupus erythematosus / Harjit Pal Bhattoa, Emese Kiss, Peter Bettembuk, Adam Balogh
Dátum:	2001
ISSN:	0172-8172
Megjegyzések:	The aim of this study was to evaluate bone mineral density (BMD), biochemical markers of bone turnover, and hormone levels in men with systemic lupus erythematosus (SLE). BMD at L2-L4 lumbar vertebrae (LS), left proximal femur neck, and radius at the ultradistal and mid-33% region was measured by dual-energy X-ray absorptiometry in 23 men with SLE (mean age, disease duration, and cumulative corticosteroid dose were 45.6 years, 11.9 years, and 33.410 g, respectively) and 40 healthy, age- and sex-matched controls. Biochemical markers of bone turnover, parathyroid hormone and 25-hydroxyvitamin D (25-OH-D), testosterone, and dehydroepiandrosterone sulfate (DHEAS) levels were measured. There was no difference in BMD between the SLE and control group. The prevalence of osteoporosis was 17.4% (4 out of 23), found at LS. Biochemical markers of bone turnover were within the reference range. There was a high prevalence of hypovitaminosis D (65.2%), hypotestosteronism (62.5%), and hypodehydroepiandrosterone sulfate (100%). There was no correlation between BMD and duration of disease, corticosteroid doses, SLE Disease Activity Index (SLEDAI), SLE Collaboration Clinics/American College of Rheumatology (SLICC/ARC) damage index, or markers of bone turnover. Bone-specific alkaline phosphatase (BSAP) (r, -0.500; P = 0.018) and DHEAS (r, -0.511; P = 0.013) correlated with daily corticosteroid dose. Despite corticosteroid therapy, bone mass in men with SLE was not decreased.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény Biochemical markers of bone turnover Bone mineral density Corticosteroids Hormones Men Systemic lupus erythematosus 25 hydroxyvitamin D alkaline phosphatase biological marker corticosteroid prasterone sulfate testosterone adult aged article body mass bone density bone mineral bone turnover clinical article controlled study disease activity disease duration dual energy X ray absorptiometry femur neck human lumbar vertebra male osteoporosis priority journal systemic lupus erythematosus vitamin deficiency Aged Alkaline Phosphatase Bone Density Bone Remodeling Cross-Sectional Studies Female Glucocorticoids Humans Lupus Erythematosus, Systemic Male Middle Aged
Megjelenés:	Rheumatology International. - 21 : 3 (2001), p. 97-102. -
További szerzők:	Kiss Emese (1960-) (belgyógyász, immunológus) Bettembuk Péter Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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