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1.

001-es BibID:BIBFORM067626
035-os BibID:(Scopus)85006974982 (WOS)000392280100027 (cikkazonosító)1256
Első szerző:Boucher, Barbara
Cím:Exploring the Role of Vitamin D. Comments on Fleury et al. Sun Exposure and Its Effects on Human Health : mechanisms through Which Sun Exposure Could Reduce the Risk of Developing Obesity and Cardiometabolic Dysfunction / Boucher Barbara J., Grant William B., Bhattoa Harjit Pal
Dátum:2016
ISSN:1661-7827 1660-4601
Tárgyszavak:Orvostudományok Elméleti orvostudományok hozzászólás
folyóiratcikk
Megjelenés:International Journal of Environmental Research and Public Health. - 13 : 12 (2016), p. 1256. -
További szerzők:Grant, William B. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
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2.

001-es BibID:BIBFORM116025
035-os BibID:(Scopus)85179259710
Első szerző:Grant, William B.
Cím:Determinants of vitamin D levels from sun exposure : a global perspective / William B. Grant, Harjit P. Bhattoa, Pawel Pludowski
Dátum:2024
Megjegyzések:Vitamin D deficiency, generally defined as 25-hydroxyvitamin D (25(OH)D) concentration <50 nmol/L, affects nearly half the world's population. However, optimal 25(OH)D concentration is much higher, depending on the particular outcome. Solar ultraviolet B (UVB) exposure is the primary source of vitamin D for most people. Wintertime 25(OH)D concentrations are maintained at 60%-80% of summertime concentrations through a combination of recirculating 25(OH)D stored in muscle cells, oral intake, and at lower latitudes, some UVB exposure. Many factors affect 25(OH)D concentrations related to solar UVB exposure, including skin pigmentation, solar zenith angle, atmospheric aerosols and clouds, time spent in the sun, amount of skin surface area exposed, use of sunscreen, age, and body mass index. Cultural and lifestyle differences - such as beauty standards, including high regard for fair skin in darker-skinned populations and avoidance of wrinkling, occupation, religion-related clothing, urban/rural residence, and fear of developing skin cancer or melanoma - also affect some of those factors. Thus, fortification of food with vitamin D and vitamin D supplementation would have to be employed to compensate for unavoidable or inconvenient lack of solar UVB exposure.
ISBN:978-0-323-91338-6
Tárgyszavak:Orvostudományok Klinikai orvostudományok könyvfejezet
könyvrészlet
Megjelenés:Feldman and Piké's Vitamin D, fifth Edition / eds. Hewison M., Bouillon R., Giovannucci E., Goltzman D., Meyer M., Welsh J.. - p. 97-113. -
További szerzők:Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Pludowski, Pawel
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3.

001-es BibID:BIBFORM091926
Első szerző:Grant, William B.
Cím:Nursing home residents could reduce risk of COVID-19 by supplementing with vitamin D3 - Rapid Response to : Covid-19: Continued outbreaks in care homes risk extending pandemic, say experts / William B. Grant, Carole A. Baggerly, Harjit P. Bhattoa, Barbara J. Boucher, Meis Moukayed, Pawel Pludowski
Dátum:2020
ISSN:1756-1833
Tárgyszavak:Orvostudományok Klinikai orvostudományok hozzászólás
folyóiratcikk
Megjelenés:BMJ. - 369 (2020), p. m2530. -
További szerzők:Baggerly, Carole A. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Boucher, Barbara Moukayed, Meis Pludowski, Pawel
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4.

001-es BibID:BIBFORM084709
035-os BibID:(cikkazonosító)988 (WoS)000531831300108 (Scopus)85083006648
Első szerző:Grant, William B.
Cím:Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths / Grant William B., Lahore Henry, McDonnell Sharon L., Baggerly Carole A., French Christine B., Aliano Jennifer L., Bhattoa Harjit P.
Dátum:2020
ISSN:2072-6643
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
COVID-19
SARS-CoV-2
Megjelenés:Nutrients. - 12 : 4 (2020), p. 1-19. -
További szerzők:Lahore, Henry McDonnell, Sharon L. Baggerly, Carole A. French, Christine B. Aliano, Jennifer L. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
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5.

001-es BibID:BIBFORM081577
035-os BibID:(cikkazonosító)2065 (WoS)000487964600213 (Scopus)85071735858 (PMID)31484329
Első szerző:Grant, William B.
Cím:Variations in 25-Hydroxyvitamin D in Countries from the Middle East and Europe : the Roles of UVB Exposure and Diet / William B. Grant, Hana M. A. Fakhoury, Spyridon N. Karras, Fatme Al Anouti, Harjit P. Bhattoa
Dátum:2019
ISSN:2072-6643
Megjegyzések:Serum 25-hydroxyvitamin D (25(OH)D) has been largely associated with latitude and sunshine exposure across several regions. According to previous results, 25(OH)D concentrations are, on average, relatively low in countries with abundant sunshine, including those of the Middle East and North Africa region, as well as lower-latitude Europe. The standard explanation for this phenomenon is that people wear concealing clothing because of cultural and religious practices and that high temperatures in summer limit direct sun exposure. However, the role of diet in the development of profound hypovitaminosis D has not been adequately explored in those countries. To examine how diet affects vitamin D status in the Middle Eastern and European countries, a search was conducted for papers from that region reporting 25(OH)D concentrations. Papers were sought that reported summertime and wintertime 25(OH)D concentrations for healthy nonpregnant adults representative of the entire population. Data from 15 Middle Eastern and European countries were found through this search. Data for postmenopausal women from 19 European countries were also obtained. Dietary supply data for animal products containing vitamin D (animal fat, eggs, ocean fish, animal meat, and milk) were obtained from the Food and Agriculture Organization of the United Nations. Latitude and a solar UVB dose index also were obtained for each country. For the 15-country study, energy from dietary factors was highly correlated with latitude, making it difficult to separate the effects of UVB exposure and dietary factors. However, for the 19-country study, dietary factors were only weakly correlated with latitude. In that study, ocean fish was the most important single dietary factor affecting serum 25(OH)D concentration for postmenopausal women in various European countries, but animal fat and meat also contributed. Because this is an ecological study, further research is encouraged to evaluate and extend the findings.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
25-hydroxyvitamin D
Europe
Middle East
animal fat
diet
eggs
latitude
ocean fish
solar UVB
vitamin D deficiency
Megjelenés:Nutrients. - 11 : 9 (2019), p. 1-16. -
További szerzők:Fakhoury, Hana M. A. Karras, Spyridon Al Anouti, Fatme Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
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6.

001-es BibID:BIBFORM073722
Első szerző:Grant, William B.
Cím:Why vitamin D clinical trials should be based on 25-hydroxyvitamin D concentrations / Grant William B., Boucher Barbara J., Bhattoa Harjit P., Lahore Henry
Dátum:2018
ISSN:0960-0760
Megjegyzések:Many health benefits are attributed to vitamin D, with those findings supported mostly by observational outcome studies of relationships to serum 25-hydroxyvitamin D [25(OH)D]. However, many randomized controlled trials (RCTs) aiming to confirm those findings have failed, perhaps because serum 25(OH)D is an index of UVB exposure and non-vitamin D mechanisms or because disease reduces serum 25(OH)D content. But the most likely reason for that failure is inappropriate design, conduct, analysis, and interpretation of RCTs. Most RCTs used principles designed to test pharmaceutical drugs; that design incorporates the assumptions that the RCT is the sole source of the agent and that dose-response relationships are linear. However, neither assumption is true for vitamin D, since neither vitamin D dose-responses or health outcome-serum 25(OH)D concentration relationships are linear?larger changes being induced with low rather than high baseline 25(OH)D values. Here, we propose a hybrid observational approach to vitamin D RCT design, based primarily on serum 25(OH)D concentration, requiring an understanding of serum 25(OH)D concentration-health outcome relationships, measuring baseline 25(OH)D values, recruiting non-replete subjects, measuring serum 25(OH)D during the trial for adjustment of supplemental doses for achievement of pretrial selection of target 25(OH)D values, where possible, and analyzing health outcomes in relation to those data rather than solely to vitamin D dosages.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Vitamin D
Randomized controlled trial
clinical trial
25-hydroxyvitamin D
observational study
Megjelenés:Journal Of Steroid Biochemistry And Molecular Biology. - 177 (2018), p. 266-269. -
További szerzők:Boucher, Barbara Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Lahore, Henry
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7.

001-es BibID:BIBFORM073727
Első szerző:Grant, William B.
Cím:Determinants of Vitamin D Deficiency From Sun Exposure : a Global Perspective / Grant William B., Bhattoa Harjit Pal, Pludowski Pawel
Dátum:2018
Megjegyzések:Vitamin D deficiency, generally defined as 25-hydroxyvitamin D (25(OH)D) concentration <50 nmol/L, affects nearly half the world's population. Solar ultraviolet B (UVB) exposure is the primary source of vitamin D for most people. Many factors affect 25(OH)D concentrations related to solar UVB exposure, including skin pigmentation, solar zenith angle, atmospheric aerosols and clouds, time spent in the sun, amount of skin surface area exposed, use of sunscreen, age, and body mass index. Cultural and lifestyle differences?such as beauty standards, including high regard for fair skin in darker-skinned populations and avoidance of wrinkling; occupation; religion; urban/rural residence; and fear of developing skin cancer or melanoma?also affect some of those factors. Thus, fortification of food with vitamin D and vitamin D supplementation would have to be employed to compensate for unavoidable or inconvenient lack of solar UVB exposure.
ISBN:978-0-12-809963-6
Tárgyszavak:Orvostudományok Klinikai orvostudományok könyvfejezet
25-Hydroxyvitamin D
Shadow rule
Skin cancer
Solar
Sunscreen
Ultraviolet B
Vitamin D
Megjelenés:Vitamin D (4th edition) / Ed. Feldman David, Pike J. Wesley, Bouillon Roger, Giovannucci Edward, Goltzman David, Hewison Martin. - p. 79-90. -
További szerzők:Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Pludowski, Pawel
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8.

001-es BibID:BIBFORM067622
Első szerző:Grant, William B.
Cím:Seasonal variations of U.S. mortality rates : roles of solar ultraviolet-B doses, vitamin D, gene expression, and infections / Grant William B., Bhattoa Harjit Pal, Boucher Barbara J.
Dátum:2017
Megjegyzések:Death rates in the U.S. show a pronounced seasonality. The broad seasonal variation shows about 25% higher death rates in winter than in summer with an additional few percent increase associated with the Christmas and New Year's holidays. A pronounced increase in death rates also starts in mid-September, shortly after the school year begins. The causes of death with large contributions to the observed seasonality include diseases of the circulatory system; the respiratory system; the digestive system; and endocrine, nutritional, and metabolic diseases. Researchers have identified several factors showing seasonal variation that could possibly explain the seasonal variations in mortality rate. These factors include seasonal variations in solar ultraviolet-B(UVB) doses and serum 25-hydroxyvitamin D [25(OH)D] concentrations, gene expression, ambient temperature and humidity, UVB effects on environmental pathogen load, environmental pollutants and allergens, and photoperiod (or length of day). The factors with the strongest support in this analysis are seasonal variations in solar UVB doses and 25(OH)D concentrations. In the U.S., population mean 25(OH)D concentrations range from 21 ng/mL in March to 28 ng/mL in August. Measures to ensure that all people had 25(OH)D concentrations >36 ng/mL year round would probably reduce death rates significantly.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Vitamin D
Cardiovascular disease
Mortality rate
Season
Respiratory tract infections
Temperature
Gene expression
Megjelenés:The Journal of Steroid Biochemistry and Molecular Biology 173 (2017), p. 5-12. -
További szerzők:Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Boucher, Barbara
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9.

001-es BibID:BIBFORM068611
Első szerző:Jakab Éva
Cím:Standardizing 25-hydroxyvitamin D data from the HunMen cohort / E. Jakab, E. Kalina, Z. Petho, Z. Pap, A. Balogh, W. B. Grant, H. P. Bhattoa
Dátum:2017
ISSN:0937-941X
Megjegyzések:Summary Standardization of 25-hydroxyvitamin D (25OHD)values is still a challenge.We propose standardization by correctionof the measured 25OHD values using the linear regressionbias from the National Institute of Standards andTechnology (NIST) ♭total' target values reported by VitaminD External Quality Assessment Scheme (DEQAS). Our approachcould perhaps be a practical solution to the anomalysurrounding non-standardized 25OHD values.Introduction Standardization of 25OHD values is still a challenge.We propose standardization by correction of the measured25OHD values using the linear regression equation derivedfrom the analysis of relationship between total 25OHDvalues measured by the methodology used by the laboratoryand the NIST total target values (TV) reported by the DEQASfor all 5 of the DEQAS samples in a given survey.Methods We applied our approach to standardize total25OHD values of the HunMen cohort.Results All 206 samples for the HunMen cohort were evaluatedusing the automated Liaison DiaSorin total 25OHDchemiluminescence immunoassay (CLIA). The timing ofthese measurements coincided with that of the October 2015DEQAS survey using samples 481 to 485. Following standardization,the mean total 25OHD changed from 53 to62 nmol/L and the prevalence of hypovitaminosis D(<75 nmol/L) decreased significantly from 84 to 72%.Conclusion A simple approach readily applicable at the routinediagnostic laboratory could perhaps be a practical solutionto the anomaly surrounding non-standardized 25OHD values
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
25-Hydroxyvitamin D
DEQAS
HunMen
Standardization
Megjelenés:Osteoporosis International. - 28 : 5 (2017), p. 1653-1657. -
További szerzők:Kalina Edit Pethő Zsófia (1981-) (reumatológus, immunológus) Pap Zoltán Domokos (1973-) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Grant, William B. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
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10.

001-es BibID:BIBFORM067627
Első szerző:Pludowski, Pawel
Cím:Vitamin D supplementation guidelines / Pawel Pludowski, Michael F. Holick, William B. Grant, Jerzy Konstantynowicz, Mario R. Mascarenhas, Afrozul Haq, Vladyslav Povoroznyuk, Nataliya Balatska, Ana Paula Barbosa, Tatiana Karonova, Ema Rudenka, Waldemar Misiorowski, Irina Zakharova, Alena Rudenka, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska, Natalia Laszcz, Pawel Abramowicz, Harjit P. Bhattoa, Sunil J. Wimalawansa
Dátum:2018
Megjegyzések:Research carried out during the past two-decades extended the understanding of actions of vitamin D, from regulating calcium and phosphate absorption and bone metabolism to many pleiotropic actions in organs and tissues in the body. Most observational and ecological studies report association of higher serum 25-hydroxyvitamin D [25(OH)D] concentrations with improved outcomes for several chronic, communicable and non-communicable diseases. Consequently, numerous agencies and scientific organizations have developed recommendations for vitamin D supplementation and guidance on optimal serum 25(OH)D concentrations. The bone-centric guidelines recommend a target 25(OH)D concentration of 20 ng/mL (50 nmol/L), and age-dependent daily vitamin D doses of 400?800 IU. The guidelines focused on pleiotropic effects of vitamin D recommend a target 25(OH)D concentration of 30 ng/mL (75 nmol/L), and age-, body weight-, disease-status, and ethnicity dependent vitamin D doses ranging between 400 and 2000 IU/day. The wise and balanced choice of the recommendations to follow depends on one's individual health outcome concerns, age, body weight, latitude of residence, dietary and cultural habits, making the regional or nationwide guidelines more applicable in clinical practice. While natural sources of vitamin D can raise 25(OH)D concentrations, relative to dietary preferences and latitude of residence, in the context of general population, these sources are regarded ineffective to maintain the year-round 25(OH)D concentrations in the range of 30?50 ng/mL (75?125 nmol/L). Vitamin D self-administration related adverse effects, such as hypercalcemia and hypercalciuria are rare, and usually result from taking extremely high doses of vitamin D for a prolonged time.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Vitamin D
25(OH)D
Pleiotropic
Extra-skeletal effects
Global
Recommendations
Megjelenés:The Journal of Steroid Biochemistry and Molecular Biology 175 (2018), p. 125-135. -
További szerzők:Holick, Michael F. Grant, William B. Konstantynowicz, Jerzy Mascarenhas, Mario R. Haq, Afrozul Povoroznyuk, Vladyslav Balatska, Nataliya Barbosa, Ana Paula Karonova, Tatiana Rudenka, Ema Misiorowski, Waldemar Zakharova, Irina Rudenka, Alena Łukaszkiewicz, Jacek Marcinowska-Suchowierska, Ewa Laszcz, Natalia Abramowicz, Pawel Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Wimalawansa, Sunil J.
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11.

001-es BibID:BIBFORM054103
035-os BibID:Article ID: 589587
Első szerző:Pludowski, Pawel
Cím:Vitamin D Status in Central Europe / Pawel Pludowski, William B. Grant, Harjit Pal Bhattoa, Milan Bayer, Vladyslav Povoroznyuk, Ema Rudenka, Heorhi Ramanau, Szabolcs Varbiro, Alena Rudenka, Elzbieta Karczmarewicz, Roman Lorenc, Justyna Czech-Kowalska, Jerzy Konstantynowicz
Dátum:2014
ISSN:1687-8337 1687-8345
Megjegyzések:Little published information is available regarding epidemiological data on vitamin D status in the large geographical region ofCentral Europe (CE). We searched the journal literature with regard to 25(OH)D concentrations among community-dwelling orhealthy people living in CE. 25(OH)D concentrations varied by age, season, study sample size, andmethodological approach [i.e.,25(OH)D assay used]. Concentrations of 25(OH)D in CE appeared lower than 30 ng/mL, and the magnitude of hypovitaminosisD was similar to that reported inWestern Europe.While most of the studies reviewed were cross-sectional studies, a longitudinalstudy was also included to obtain information on seasonal variability. The longitudinal study reported wintertime 25(OH)D valuesclose to 21?23 ng/mL for all studied age groups, with a significant increase of 25(OH)D in August reaching 42 ng/mL for thoseaged 0?9 years, but only 21 ng/mL for the elderly aged 80?89 years.The decrease in 25(OH)D with respect to age was attributed todecreased time spent in the sun and decreased vitamin D production efficiency. Based on the literature review on vitamin D statusin the CE populations, it can be concluded that 25(OH)vitamin D levels are on average below the 30 ng/mL level.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
vitamin d, 25(OH)D,
Megjelenés:International Journal of Endocrinology. - 2014 (2014), [13] p. -
További szerzők:Grant, William B. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Bayer, Milan Povoroznyuk, Vladyslav Rudenka, Ema Ramanau, Heorhi Várbíró Szabolcs Rudenka, Alena Karczmarewicz, Elzbieta Lorenc, Roman Czech-Kowalska, Justyna Konstantynowicz, Jerzy
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