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001-es BibID:	BIBFORM067627
Első szerző:	Pludowski, Pawel
Cím:	Vitamin D supplementation guidelines / Pawel Pludowski, Michael F. Holick, William B. Grant, Jerzy Konstantynowicz, Mario R. Mascarenhas, Afrozul Haq, Vladyslav Povoroznyuk, Nataliya Balatska, Ana Paula Barbosa, Tatiana Karonova, Ema Rudenka, Waldemar Misiorowski, Irina Zakharova, Alena Rudenka, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska, Natalia Laszcz, Pawel Abramowicz, Harjit P. Bhattoa, Sunil J. Wimalawansa
Dátum:	2018
Megjegyzések:	Research carried out during the past two-decades extended the understanding of actions of vitamin D, from regulating calcium and phosphate absorption and bone metabolism to many pleiotropic actions in organs and tissues in the body. Most observational and ecological studies report association of higher serum 25-hydroxyvitamin D [25(OH)D] concentrations with improved outcomes for several chronic, communicable and non-communicable diseases. Consequently, numerous agencies and scientific organizations have developed recommendations for vitamin D supplementation and guidance on optimal serum 25(OH)D concentrations. The bone-centric guidelines recommend a target 25(OH)D concentration of 20 ng/mL (50 nmol/L), and age-dependent daily vitamin D doses of 400?800 IU. The guidelines focused on pleiotropic effects of vitamin D recommend a target 25(OH)D concentration of 30 ng/mL (75 nmol/L), and age-, body weight-, disease-status, and ethnicity dependent vitamin D doses ranging between 400 and 2000 IU/day. The wise and balanced choice of the recommendations to follow depends on one's individual health outcome concerns, age, body weight, latitude of residence, dietary and cultural habits, making the regional or nationwide guidelines more applicable in clinical practice. While natural sources of vitamin D can raise 25(OH)D concentrations, relative to dietary preferences and latitude of residence, in the context of general population, these sources are regarded ineffective to maintain the year-round 25(OH)D concentrations in the range of 30?50 ng/mL (75?125 nmol/L). Vitamin D self-administration related adverse effects, such as hypercalcemia and hypercalciuria are rare, and usually result from taking extremely high doses of vitamin D for a prolonged time.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Vitamin D 25(OH)D Pleiotropic Extra-skeletal effects Global Recommendations
Megjelenés:	The Journal of Steroid Biochemistry and Molecular Biology 175 (2018), p. 125-135. -
További szerzők:	Holick, Michael F. Grant, William B. Konstantynowicz, Jerzy Mascarenhas, Mario R. Haq, Afrozul Povoroznyuk, Vladyslav Balatska, Nataliya Barbosa, Ana Paula Karonova, Tatiana Rudenka, Ema Misiorowski, Waldemar Zakharova, Irina Rudenka, Alena Łukaszkiewicz, Jacek Marcinowska-Suchowierska, Ewa Laszcz, Natalia Abramowicz, Pawel Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Wimalawansa, Sunil J.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM054103
035-os BibID:	Article ID: 589587
Első szerző:	Pludowski, Pawel
Cím:	Vitamin D Status in Central Europe / Pawel Pludowski, William B. Grant, Harjit Pal Bhattoa, Milan Bayer, Vladyslav Povoroznyuk, Ema Rudenka, Heorhi Ramanau, Szabolcs Varbiro, Alena Rudenka, Elzbieta Karczmarewicz, Roman Lorenc, Justyna Czech-Kowalska, Jerzy Konstantynowicz
Dátum:	2014
ISSN:	1687-8337 1687-8345
Megjegyzések:	Little published information is available regarding epidemiological data on vitamin D status in the large geographical region ofCentral Europe (CE). We searched the journal literature with regard to 25(OH)D concentrations among community-dwelling orhealthy people living in CE. 25(OH)D concentrations varied by age, season, study sample size, andmethodological approach [i.e.,25(OH)D assay used]. Concentrations of 25(OH)D in CE appeared lower than 30 ng/mL, and the magnitude of hypovitaminosisD was similar to that reported inWestern Europe.While most of the studies reviewed were cross-sectional studies, a longitudinalstudy was also included to obtain information on seasonal variability. The longitudinal study reported wintertime 25(OH)D valuesclose to 21?23 ng/mL for all studied age groups, with a significant increase of 25(OH)D in August reaching 42 ng/mL for thoseaged 0?9 years, but only 21 ng/mL for the elderly aged 80?89 years.The decrease in 25(OH)D with respect to age was attributed todecreased time spent in the sun and decreased vitamin D production efficiency. Based on the literature review on vitamin D statusin the CE populations, it can be concluded that 25(OH)vitamin D levels are on average below the 30 ng/mL level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban vitamin d, 25(OH)D,
Megjelenés:	International Journal of Endocrinology. - 2014 (2014), [13] p. -
További szerzők:	Grant, William B. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Bayer, Milan Povoroznyuk, Vladyslav Rudenka, Ema Ramanau, Heorhi Várbíró Szabolcs Rudenka, Alena Karczmarewicz, Elzbieta Lorenc, Roman Czech-Kowalska, Justyna Konstantynowicz, Jerzy
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