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1.

001-es BibID:BIBFORM084530
035-os BibID:(WoS)000383620000028 (Scopus)84987814942
Első szerző:Bertolini, Marta
Cím:Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse / Bertolini M., Pretzlaff M., Sulk M., Bähr M., Gherardini J., Uchida Y., Reibelt M., Kinori M., Rossi A., Bíró T., Paus R.
Dátum:2016
ISSN:0007-0963 1365-2133
Megjegyzések:Background Alopecia areata (AA) is an autoimmune disorder whose pathogenesisinvolves the collapse of the relati ve immune privilege (IP) of the hair follicle(HF). Given that vasoactive intestinal peptide (VIP) is an immunoinhibitory neu-ropeptide released by perifollicular sensory nerve ?bres, which play a role in IPmaintenance, it may modulate human HF-IP and thus be therapeutically relevantfor AA.Objectives To answer the following questions: Do human HFs express VIP recep-tors, and does their stimulation protect from or restore experimentally inducedHF-IP collapse? Is VIP signalling defective in AA HFs?Methods Firstly, VIP and VIP receptor (VPAC1, VPAC2) expression in human scalpHFs and AA skin was assessed. In HF organ culture, we then explored whetherVIP treatment can restore and/or protect from interferon-c-induced HF-IP col-lapse, assessing the expression of the key IP markers by quantitative (immuno-)histomorphometry.Results Here we provide the ?rst evidence that VIP receptors are expressed in theepithelium of healthy human HFs at the gene and protein level. Furthermore,VIP receptor protein expression, but not VIP+nerve ?bres, is signi?cantly down-regulated in lesional hair bulbs of patients with AA, suggesting defects in VIPreceptor-mediated signalling. Moreover, we show that VIP protects the HF fromexperimentally induced IP collapse in vitro, but does not fully restore it once col-lapsed.Conclusions These pilot data suggest that insuf?cient VIP receptor-mediated sig-nalling may contribute to impairing HF-IP in patients with AA, and that VIP is apromising candidate ♭HF-IP guardian' that may be therapeutically exploited toinhibit the progression of AA lesions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:British Journal Of Dermatology. - 175 : 3 (2016), p. 531-541. -
További szerzők:Pretzlaff, M. Sulk, M. Bähr, M. Gherardini, Jennifer Uchida, Yohei Reibelt, M. Kinori, M. Rossi, A. Bíró Tamás (1968-) (élettanász) Paus, Ralf
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2.

001-es BibID:BIBFORM055572
Első szerző:Bíró Tamás (élettanász)
Cím:Human sebocytes : the new leptin connection? / T. Bíró
Dátum:2014
ISSN:0007-0963
Tárgyszavak:Orvostudományok Elméleti orvostudományok szerkesztőségi anyag
Megjelenés:British Journal of Dermatology. - 171 : 6 (2014), p. 1288. -
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM055571
Első szerző:Fischer, T. W.
Cím:Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and TGF-β2-/IGF-1-mediated regulation of hair cycle in male and female human hair follicles in vitro / T. W. Fischer, E. Herczeg-Lisztes, W. Funk, D. Zillikens, T. Bíró, R. Paus
Dátum:2014
ISSN:0007-0963
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Dermatology. - 171 : 5 (2014), p. 1031-1043. -
További szerzők:Lisztes Erika (1986-) (élettanász) Funk, W. Zillikens, D. Bíró Tamás (1968-) (élettanász) Paus, Ralf
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM039247
Első szerző:Havlickova, Blanka
Cím:Towards optimization of an organotypic assay system that imitates human hair follicle-like epithelial-mesenchymal interactions / Havlickova, B., Biro, T., Mescalchin, A., Arenberger, P., Paus, R.
Dátum:2004
ISSN:0007-0963
Megjegyzések:Human hair growth can currently be studied in vitro by the use of organ-cultured scalp hair follicles (HFs). However, simplified organotypic systems are needed for dissecting the underlying epithelial-mesenchymal interactions and as screening tools for candidate hair growth-modulatory agents. OBJECTIVES: To optimize the design and culture conditions of previously published organotypic systems that imitate epithelial-mesenchymal interactions in the human HF as closely as possible. MATERIALS AND METHODS: Continuous submerged organotypic 'sandwich' cultures were established. These consist of a pseudodermis (collagen I mixed with and contracted by human interfollicular dermal fibroblasts) on which one of two upper layers is placed: either a mixture of Matrigel basement membrane matrix (BD Biosciences, Bedford, MA, U.S.A.) and follicular dermal papilla fibroblasts (DPC), with outer root sheath keratinocytes (ORSK) layered on the top ('layered' system), or a mixture of Matrigel, DPC and ORSK ('mixed' system). Morphological and functional characteristics of these 'folliculoid sandwiches' were then assessed by routine histology, histomorphometry and immunohistochemistry. RESULTS: In both 'layered' and 'mixed' systems, the ORSK formed spheroid epithelial cell aggregates, which retained their characteristic keratin expression pattern (i.e. cytokeratin 6). In the 'mixed' sandwich model the size of the epithelial cell aggregates was smaller, but the numbers of ORSK were significantly higher than in the 'layered' model at day 14 in the culture. ORSK proliferated better in the 'mixed' than in the 'layered' sandwich system, regardless of the calcium or serum content of the media, whereas apoptosis of ORSK was lowest in the 'mixed' system in serum-free, low calcium medium. The kinetics of proliferation and apoptosis of DPC, which retained their characteristic expression of versican, were similar in both systems. However, proliferation and apoptosis of DPC were higher in the presence of serum and/or under high calcium conditions. CONCLUSIONS: Our results underscore the importance of structural design and medium composition for epithelial-mesenchymal interactions as they occur in the human HF. Specifically, we report a new organotypic submerged 'folliculoid sandwich' system with serum-free, low calcium medium and a mixture of interacting human DPC and ORSK, which offers several advantages over previously available assays. This system allows the standardized assessment of the effects of a test agent on the proliferation, apoptosis and key marker expression of human ORSK and DPC under substantially simplified in vitro conditions which approximate the in vivo situation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal Of Dermatology. - 151 : 4 (2004), p. 753-765. -
További szerzők:Bíró Tamás (1968-) (élettanász) Mescalchin, Alessandra Arenberger, P. Paus, Ralf
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5.

001-es BibID:BIBFORM039260
Első szerző:Holub, B. S.
Cím:The neuropeptide galanin is a novel inhibitor of human hair growth / Holub B. S., Kloepper J. E., Tóth B. I., Bíro T., Kofler B., Paus R.
Dátum:2012
ISSN:0007-0963
Megjegyzések:BACKGROUND: Galanin is a trophic factor of the central and peripheral nervous system that shows widespread distribution in human skin. However, the exact localization and the role of galanin in the hair follicle (HF) remain to be clarified. OBJECTIVES: To characterize galanin expression in human scalp HFs and to examine the effects of galanin on normal human scalp HF growth in organ culture. METHODS: Immunohistochemistry was performed on cryosections of human female scalp skin. Anagen HFs were microdissected and cultured up to 9 days and treated with 100 nmol L(-1) galanin. Staining for Ki-67, TUNEL and Masson-Fontana were used to analyse proliferation, apoptosis and hair cycle staging of the HFs. Functional effects of galanin were tested in serum-free HF organ culture. RESULTS: Galanin-like immunoreactivity was detected in the outer root sheath (ORS) and inner root sheath. Additionally, galanin mRNA was detected in ORS keratinocytes and all HF samples tested. Galanin receptor transcripts (GalR2, GalR3) were also detected in selected samples. Galanin reduced proliferation of hair matrix keratinocytes in situ compared with vehicle-treated controls, shortened the hair growth phase (anagen) in vitro and reduced hair shaft elongation. This was accompanied by the premature development of a catagen-like morphology of galanin-treated HFs. CONCLUSIONS: We present the first evidence that human HFs are both a source and a functionally relevant target of galanin. Due to its hair growth-inhibitory properties in vitro, galanin application deserves further exploration as a potential new treatment strategy for unwanted hair growth (hirsutism, hypertrichosis).
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal Of Dermatology. - 167 : 1 (2012), p. 10-16. -
További szerzők:Kloepper, Jennifer E. Tóth István Balázs (1978-) (élettanász) Bíró Tamás (1968-) (élettanász) Kofler, Barbara Paus, Ralf
Pályázati támogatás:Austrian Research Promotion Agency FFG
Egyéb
822782/THERAPEP
Egyéb
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6.

001-es BibID:BIBFORM041512
Első szerző:Langan, Ewan A.
Cím:Dopamine is a novel, direct inducer of catagen in human scalp hair follicles in vitro / E. A. Langan, E. Lisztes, T. Bíró, W. Funk, J. E. Kloepper, C. E. M. Griffiths, R. Paus
Dátum:2013
ISSN:0007-0963
Megjegyzések:Background? Although there are clinical reports of hair loss associated with levodopa and dopamine agonists, it is unclear whether dopamine exerts any direct effects on the human hair follicle (HF). Objectives? Given the widespread use of dopamine agonists and antagonists in clinical medicine, we sought to determine whether dopamine exerts direct effects on human HF growth and/or pigmentation in vitro, and whether human HFs express dopamine receptors (DRs). Methods? Microdissected human scalp HFs from women were treated in serum-free organ culture for 7?days with dopamine (10-1000?nmol?L(-1) ), and the effects on hair shaft production, HF cycling (i.e. anagen-catagen transition), hair matrix keratinocyte proliferation and apoptosis, and HF pigmentation were measured by quantitative (immuno-) histomorphometry. Results? Dopamine had no consistent effect on hair shaft production, but did promote HF regression (catagen). It was also associated with significantly reduced proliferation of HF matrix keratinocytes (P?<?0?01) and reduced intrafollicular melanin production. Dopamine receptor transcripts were identified in HFs and skin. Conclusions? These data provide evidence that dopamine is an inhibitor of human hair growth, via the promotion of catagen induction, at least in vitro. This may offer a rational explanation for the induction of telogen effluvium in some women treated with dopamine agonists such as bromocriptine. Moreover, dopaminergic agonists deserve further exploration as novel inhibitors of unwanted human hair growth (hirsutism, hypertrichosis)
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Dermatology. - 168 : 3 (2013), p. 520-525. -
További szerzők:Lisztes Erika (1986-) (élettanász) Bíró Tamás (1968-) (élettanász) Funk, W. Kloepper, Jennifer E. Griffiths, Christopher E. M. Paus, Ralf
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7.

001-es BibID:BIBFORM016011
Első szerző:Langan, Ewan A.
Cím:Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro / Langan, E. A., Ramot, Y., Hanning, A., Poeggeler, B., Biro, T., Gaspar, E., Funk, W., Griffiths, C. E. M., Paus, R.
Dátum:2010
ISSN:0007-0963
Megjegyzések:Human skin and scalp hair follicles are both a nonclassical target and an extrapituitary source of prolactin (PRL), which is a potent hair growth modulator. However, how the expression of PRL and PRL receptor (PRLR) is regulated in human skin is unknown. Objectives To investigate whether two key stimulators of pituitary PRL secretion, thyrotropin-releasing hormone (TRH) and oestrogen, also regulate cutaneous PRL and PRLR expression. Methods Female scalp skin and/or microdissected hair follicles were treated for 6 days in serum-free organ culture with oestrogen (100 nmol L-1), TRH (1-10 ng mL-1, 3-30 nm) or vehicle control. Quantitative immunohistomorphometry of skin and hair follicle sections was complemented with quantitative polymerase chain reaction for PRL and PRLR in cultured hair follicles and/or female human outer root sheath (ORS) keratinocytes. Results Oestrogen treatment significantly upregulated PRL and PRLR immunoreactivity in selected skin and hair follicle compartments, at the gene and protein level (P < 0 center dot 05). TRH significantly increased PRL immunoreactivity and transcription in hair follicles (P < 0 center dot 05); however, while it also increased PRLR transcription in hair follicles, it downregulated PRLR immunoreactivity in the hair follicle ORS (P < 0 center dot 05). Conclusions Our pilot study shows that two key endocrine controls of pituitary PRL secretion, oestrogen and TRH, also regulate PRL and PRLR expression in human skin. This provides novel insights into the regulation of extrapituitary PRL and PRLR expression, and invites exploration of oestrogen and TRH as novel therapeutic agents in the management of skin and hair diseases characterized by aberrant PRLR-mediated signalling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Dermatology. - 162 : 5 (2010), p. 1127-1131. -
További szerzők:Ramot, Yuval Hanning, A. Poeggeler, Burkhard Bíró Tamás (1968-) (élettanász) Gáspár E. Funk, W. Griffiths, Christopher E. M. Paus, Ralf
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8.

001-es BibID:BIBFORM048966
Első szerző:Mócsai Gábor (PhD hallgató)
Cím:Severe skin inflammation and filaggrin mutation similarly alter skin barrier in atopic dermatitis patients / Gábor Mócsai, Krisztián Gáspár, Georgina Nagy, Beatrix Irinyi, Anikó Kapitány, Tamás Bíró, Edit Gyimesi, Beáta Tóth, László Maródi, Andrea Szegedi
Dátum:2014
ISSN:0007-0963
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Dermatology. - 170 : 3 (2014), p. 617-624. -
További szerzők:Gáspár Krisztián (1974-) (bőrgyógyász) Nagy Georgina (1980-) (orvosbiológus) Irinyi Beatrix (1972-) (bőrgyógyász, allergológus) Kapitány Anikó (1979-) (molekuláris biológus) Bíró Tamás (1968-) (élettanász) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Lajszné Tóth Beáta (1978-) (molekuláris biológus) Maródi László (1949-) (gyermekgyógyász infektológus, immunológus) Szegedi Andrea (1964-) (bőrgyógyász)
Pályázati támogatás:K81381
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0023-"VÉD-ELEM"
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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9.

001-es BibID:BIBFORM041520
Első szerző:Ramot, Yuval
Cím:Is thyrotropin-releasing hormone (TRH) a novel neuroendocrine modulator of keratin expression in human skin? / Y. Ramot, G. Zhang, T. Bíró, L. Langbein, R. Paus
Dátum:2013
ISSN:0007-0963
Megjegyzések:BACKGROUND: Hair and epithelial keratins constitute the major structural components of the skin and its appendages, including the hair fiber. While selected steroid hormones are appreciated to regulate specific keratins, little is known about the neuroendocrine control of human hair keratin expression. Preliminary evidence had suggested that thyrotropin-releasing hormone (TRH) may regulate keratin gene transcription. OBJECTIVE: We wanted to clarify whether TRH operates as a novel neuroendocrine regulator of human hair and epithelial keratin expression under physiologically relevant conditions in situ. METHODS: Microdissected human female scalp hair follicles (HFs) and female scalp skin were treated in serum-free organ culture for 12h - 6d with 100ng/ml TRH or vehicle. Both quantitative immunohistomorphometry and RT-qPCR were utilized to assess expression of selected keratins. RESULTS: TRH significantly increased expression of the hair keratins K31 and K32, while that of K85 and K86, and of the epithelial keratins K14 and K17 was reduced. In the interfollicular epidermis, TRH stimulated expression of K6, K14 and K17, both at the mRNA and protein levels. Stimulation of the same keratins was also evident in the eccrine sweat and sebaceous glands. CONCLUSIONS: Selected human hair and epithelial keratins are modulated in situ. This may be relevant to explain hair shaft growth-promoting effects of TRH. Our pilot study suggests that the neuroendocrine controls that regulate the expression of human keratins deserve more systematic exploration and that these may be harnessed therapeutically.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Dermatology. - 169 : 1 (2013), p. 146-151. -
További szerzők:Zhang, Guoyou Bíró Tamás (1968-) (élettanász) Langbein, Lutz Paus, Ralf
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10.

001-es BibID:BIBFORM072428
035-os BibID:(WoS)000394755100030 (Scopus)85010777987
Első szerző:Szabó K.
Cím:Factors shaping the composition of the cutaneous microbiota / K. Szabo, L. Erdei, B. Sz. Bolla, G. Tax, T. Bíró, L. Kemeny
Dátum:2017
ISSN:0007-0963 1365-2133
Megjegyzések:From birth, we are constantly exposed to bacteria, fungi and viruses, some of which are capable of transiently or permanently inhabiting our different body parts as our microbiota. The majority of our microbial interactions occur during and after birth, and several different factors, including age, sex, genetic constitution, environmental conditions and lifestyle, have been suggested to shape the composition of this microbial community. Propionibacterium acnes is one of the most dominant lipophilic microbes of the postadolescent, sebum-rich human skin regions. Currently, the role of this bacterium in the pathogenesis of the most common inflammatory skin disease, acne vulgaris, is a topic of intense scientific debate. Recent results suggest that Westernization strongly increases the dominance of the Propionibacterium genus in human skin compared with natural populations living more traditional lifestyles. According to the disappearing microbiota hypothesis proposed by Martin Blaser, such alterations in the composition of our microbiota are the possible consequences of socioeconomic and lifestyle changes occurring after the industrial revolution. Evanescence of species that are important elements of the human ecosystem might lead to the overgrowth and subsequent dominance of others because of the lack of ecological competition. Such changes can disturb the fine-tuned balance of the human body and, accordingly, our microbes developed through a long co-evolutionary process. These processes might lead to the transformation of a seemingly harmless species into an opportunistic pathogen through bacterial dysbiosis. This might have happened in the case of P. acnes in acne pathogenesis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
PROPIONIBACTERIUM-ACNES BIOFILMS
HUMAN SKIN MICROBIOME
VERNIX CASEOSA
SEBACEOUS GLAND
AGE
VULGARIS
DISEASES
BARRIER
PREVALENCE
RESISTANCE
Megjelenés:British Journal of Dermatology. - 176 : 2 (2017), p. 344-351. -
További szerzők:Erdei László (Szeged) Bolla B. Sz. (Szeged) Tax, Gábor Bíró Tamás (1968-) (élettanász) Kemény Lajos V. (bőrgyógyász Szeged)
Pályázati támogatás:OTKA NK105369
OTKA
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