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1.

001-es BibID:BIBFORM001012
Első szerző:Bodó Enikő
Cím:Dissecting the impact of chemotherapy on the human hair follicle : a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy / Bodó E., Tobin D. J., Kamenisch Y., Bíró T., Berneburg M., Funk W., Paus R.
Dátum:2007
ISSN:0002-9440 (Print)
Megjegyzések:Chemotherapy-induced alopecia represents one of the major unresolved problems of clinical oncology. The underlying molecular pathogenesis in humans is virtually unknown because of the lack of adequate research models. Therefore, we have explored whether microdissected, organ-cultured, human scalp hair follicles (HFs) in anagen VI can be exploited for dissecting and manipulating the impact of chemotherapy on human HFs. Here, we show that these organ-cultured HFs respond to a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC), in a manner that resembles chemotherapy-induced HF dystrophy as it occurs in vivo: namely, 4-HC induced melanin clumping and melanin incontinence, down-regulated keratinocyte proliferation, massively up-regulated apoptosis of hair matrix keratinocytes, prematurely induced catagen, and up-regulated p53. In addition, 4-HC induced DNA oxidation and the mitochondrial DNA common deletion. The organ culture system facilitated the identification of new molecular targets for chemotherapy-induced HF damage by microarray technology (eg, interleukin-8, fibroblast growth factor-18, and glypican 6). It was also used to explore candidate chemotherapy protectants, for which we used the cytoprotective cytokine keratinocyte growth factor as exemplary pilot agent. Thus, this novel system serves as a powerful yet pragmatic tool for dissecting and manipulating the impact of chemotherapy on the human HF.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The American Journal of Pathology. - 171 : 4 (2007), p. 1153-1167. -
További szerzők:Tobin, Desmund J. Kamenisch, York Berneburg, Mark Funk, Wolfgang Paus, Ralf Bíró Tamás (1968-) (élettanász)
Internet cím:elektronikus változat
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DOI
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2.

001-es BibID:BIBFORM039252
Első szerző:Gáspár Erzsébet
Cím:Thyrotropin-Releasing Hormone Selectively Stimulates Human Hair Follicle Pigmentation / Gáspár, Erzsébet, Nguyen-Thi, Kim T, Hardenbicker Celine, Tiede Stephan, Plate Christian, Bodó Enikő, Knuever Jana, Funk Wolfgang, Bíró Tamás, Paus Ralf
Dátum:2011
ISSN:0022-202X
Megjegyzések:In amphibians, thyrotropin-releasing hormone (TRH) stimulates skin melanophores by inducing secretion of α-melanocyte-stimulating hormone in the pituitary gland. However, it is unknown whether this tripeptide neurohormone exerts any direct effects on pigment cells, namely, on human melanocytes, under physiological conditions. Therefore, we have investigated whether TRH stimulates pigment production in organ-cultured human hair follicles (HFs), the epithelium of which expresses both TRH and its receptor, and/or in full-thickness human skin in situ. TRH stimulated melanin synthesis, tyrosinase transcription and activity, melanosome formation, melanocyte dendricity, gp100 immunoreactivity, and microphthalmia-associated transcription factor expression in human HFs in a pituitary gland-independent manner. TRH also stimulated proliferation, gp100 expression, tyrosinase activity, and dendricity of isolated human HF melanocytes. However, intraepidermal melanogenesis was unaffected. As TRH upregulated the intrafollicular production of "pituitary" neurohormones (proopiomelanocortin transcription and ACTH immunoreactivity) and as agouti-signaling protein counteracted TRH-induced HF pigmentation, these pigmentary TRH effects may be mediated in part by locally generated melanocortins and/or by MC-1 signaling. Our study introduces TRH as a novel, potent, selective, and evolutionarily highly conserved neuroendocrine factor controlling human pigmentation in situ. This physiologically relevant and melanocyte sub-population-specific neuroendocrine control of human pigmentation deserves clinical exploration, e.g., for preventing or reversing hair graying.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Investigative Dermatology. - 131 : 12 (2011), p. 2368-2377. -
További szerzők:Nguyen-Thi, Kim T Hardenbicker, Celine Tiede, Stephan Plate, Christian Bodó Enikő Knüver, Jana Funk, Wolfgang Bíró Tamás (1968-) (élettanász) Paus, Ralf
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DOI
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3.

001-es BibID:BIBFORM048815
Első szerző:Langan, Ewan A.
Cím:Tumour necrosis factor alpha, interferon gamma and substance P are novel modulators of extrapituitary prolactin expression in human skin / Ewan A. Langan, Silvia Vidali, Natascha Pigat, Wolfgang Funk, Erika Lisztes, Tamás Bíró, Vincent Goffin, Christopher E. M. Griffiths, Ralf Paus
Dátum:2013
ISSN:1932-6203
Megjegyzések:Human scalp skin and hair follicles (HFs) are extra-pituitary sources of prolactin (PRL). However, the intracutaneous regulation of PRL remains poorly understood. Therefore we investigated whether well-recognized regulators of pituitary PRL expression, which also impact on human skin physiology and pathology, regulate expression of PRL and its receptor (PRLR) in situ. This was studied in serum-free organ cultures of microdissected human scalp HFs and skin, i.e. excluding pituitary, neural and vascular inputs. Prolactin expression was confirmed at the gene and protein level in human truncal skin, where its expression significantly increased (p?=?0.049) during organ culture. There was, however, no evidence of PRL secretion into the culture medium as measured by ELISA. PRL immunoreactivity (IR) in female human epidermis was decreased by substance P (p?=?0.009), while neither the classical pituitary PRL inhibitor, dopamine, nor corticotropin-releasing hormone significantly modulated PRL IR in HFs or skin respectively. Interferon (IFN) ? increased PRL IR in the epithelium of human HFs (p?=?0.044) while tumour necrosis factor (TNF) ? decreased both PRL and PRLR IR. This study identifies substance P, TNF? and IFN? as novel modulators of PRL and PRLR expression in human skin, and suggests that intracutaneous PRL expression is not under dopaminergic control. Given the importance of PRL in human hair growth regulation and its possible role in the pathogenesis of several common skin diseases, targeting intracutaneous PRL production via these newly identified regulatory pathways may point towards novel therapeutic options for inflammatory dermatoses.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:PLoS One. - 8 : 4 (2013), p. e60819. -
További szerzők:Vidali, Silvia Pigat, Natascha Funk, Wolfgang Lisztes Erika (1986-) (élettanász) Bíró Tamás (1968-) (élettanász) Goffin, Vincent Griffiths, Christopher E. M. Paus, Ralf
Internet cím:DOI
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4.

001-es BibID:BIBFORM039257
Első szerző:Sugawara, Koji
Cím:Endocannabinoids limit excessive mast cell maturation and activation in human skin / Koji Sugawara, Tamás Bíró, Daisuke Tsuruta, Balázs I. Tóth, Arno Kromminga, Nóra Zákány, Anne Zimmer, Wolfgang Funk, Bernhard F. Gibbs, Andreas Zimmer, Ralf Paus
Dátum:2012
ISSN:0091-6749
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Endocannabinoid
cannabinoid receptor
skin
hair follicle
mast cell
stem cell factor
tryptase
Megjelenés:Journal of Allergy And Clinical Immunology 129 : 3 (2012), p. 726-738. -
További szerzők:Bíró Tamás (1968-) (élettanász) Tsuruta, Daisuke Tóth István Balázs (1978-) (élettanász) Kromminga, Arno Zákány Nóra Zimmer, Anne Funk, Wolfgang Gibbs, Bernhard F. Zimmer, Andreas Paus, Ralf
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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5.

001-es BibID:BIBFORM048833
035-os BibID:PMID:23949722
Első szerző:Vidali, Silvia
Cím:Hypothalamic-Pituitary-Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles / Silvia Vidali, Jana Knuever, Johannes Lerchner, Melanie Giesen, Tamás Bíró, Matthias Klinger, Barbara Kofler, Wolfgang Funk, Burkhard Poeggeler, Ralf Paus
Dátum:2014
ISSN:0022-202X
Megjegyzések:Thyroid hormones regulate mitochondrial function. As other hypothalamic-pituitary-thyroid (HPT) axis hormones, i.e., thyrotropin-releasing hormone (TRH) and thyrotropin (TSH), are expressed in human hair follicles (HFs) and regulate mitochondrial function in human epidermis, we investigated in organ-cultured human scalp HFs whether TRH (30?nM), TSH (10?mU?ml-1), thyroxine (T4) (100?nM), and triiodothyronine (T3) (100?pM) alter intrafollicular mitochondrial energy metabolism. All HPT-axis members increased gene and protein expression of mitochondrial-encoded subunit 1 of cytochrome c oxidase (MTCO1), a subunit of respiratory chain complex IV, mitochondrial transcription factor A (TFAM), and Porin. All hormones also stimulated intrafollicular complex I/IV activity and mitochondrial biogenesis. The TSH effects on MTCO1, TFAM, and porin could be abolished by K1-70, a TSH-receptor antagonist, suggesting a TSH receptor-mediated action. Notably, as measured by calorimetry, T3 and TSH increased follicular heat production, whereas T3/T4 and TRH stimulated ATP production in cultured HF keratinocytes. HPT-axis hormones did not increase reactive oxygen species (ROS) production. Rather, T3 and T4 reduced ROS formation, and all tested HPT-axis hormones increased the transcription of ROS scavengers (catalase, superoxide dismutase 2) in HF keratinocytes. Thus, mitochondrial biology, energy metabolism, and redox state of human HFs are subject to profound (neuro-)endocrine regulation by HPT-axis hormones. The neuroendocrine control of mitochondrial biology in a complex human mini-organ revealed here may be therapeutically exploitable.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Calcium (Ca2+) signalling
Ion channel
Membrane transport
Molecular mechanisms of disease
Skin
TRP channels
Megjelenés:Journal of Investigative Dermatology. - 134 (2014), p. 33-42. -
További szerzők:Knüver, Jana Lerchner, Johannes Giesen, Melanie Bíró Tamás (1968-) (élettanász) Klinger, Matthias Kofler, Barbara Funk, Wolfgang Poeggeler, Burkhard Paus, Ralf
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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