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001-es BibID:BIBFORM039249
Első szerző:Bíró Tamás (élettanász)
Cím:How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches / Biro, T., Ko, M. C., Bromm, B., Wei, E. T., Bigliardi, P., Siebenhaar, F., Hashizume, H., Misery, L., Bergasa, N. V., Kamei, C., Schouenborg, J., Roostermann, D., Szabo, T., Maurer, M., Bigliardi-Qi, M., Meingassner, J. G., Hossen, M. A., Schmelz, M., Steinhoff, M.
Dátum:2005
ISSN:0906-6705
Megjegyzések:While the enormous clinical and psychosocial importance of pruritus in many areas of medicine and the detrimental effects of chronic 'itch' on the quality of life of an affected individual are widely appreciated, the complexity of this sensation is still often grossly underestimated. The current Controversies feature highlights this complexity by portraying pruritus as a truly interdisciplinary problem at the crossroads of neurophysiology, neuroimmunology, neuropharmacology, protease research, internal medicine, and dermatology, which is combated most successfully if one keeps the multilayered nature of 'itch' in mind and adopts a holistic treatment approach - beyond the customary, frequently frustrane monotherapy with histamine receptor antagonists. In view of the often unsatisfactory, unidimensional, and altogether rather crude standard instruments for pruritus management that we still tend to use in clinical practice today, an interdisciplinary team of pruritus experts here critically examines recent progress in pruritus research that future itch management must take into consideration. Focusing on new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus, and discussing available neuropharmacological tools, specific research avenues are highlighted, whose pursuit promises to lead to novel, and hopefully more effective, forms of pruritus management.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Experimental Dermatology. - 14 : 3 (2005), p. 225-240. -
További szerzők:Ko, M. C. Bromm, B. Wei, E. T. Bigliardi, P. Siebenhaar, Frank Hashizume, H. Misery, L. Bergasa, N. V. Kamei, C. Schouenborg, J. Roostermann, D. Szabó T. (orvos) Maurer, Marcus Bigliardi-Qi, M. Meingassner, J. G. Hossen, M. A. Schmelz, Martin Steinhoff, Martin
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2.

001-es BibID:BIBFORM061062
Első szerző:Helyes Zsuzsanna
Cím:Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema / Zsuzsanna Helyes, Jozsef Kun, Nora Dobrosi, Katalin Sándor, Jozsef Németh, Aniko Perkecz, Erika Pintér, Krisztina Szabadfi, Balazs Gaszner, Valeria Tékus, Janos Szolcsányi, Martin Steinhoff, Hitoshi Hashimoto, Dora Reglődi, Tamas Bíró
Dátum:2015
ISSN:0022-202X
Megjegyzések:Although pituitary adenylate cyclase-activating polypeptide (PACAP) was described as a key vasoregulator inhuman skin, little is known about its expression in mouse skin. As it is important to investigate PACAP signaling intranslational mouse dermatitis models, we determined its presence, regulation, and role in neurogenic and nonneurogeniccutaneous inflammatory mechanisms. The mRNA of PACAP and its specific receptor PAC1 wasdetected with real-time PCR in several skin regions at comparable levels. PACAP-38-immunoreactivity measuredwith radioimmunoassay was similar in plantar and dorsal paw skin and the ear but significantly smaller in theback skin. PACAP and PAC1 mRNA, as well as PACAP-38 and PAC1 protein expression, significantly increased in theplantar skin after intraplantar administration of capsaicin (50 ?l, 100 ?gml?1), an agonist of the transient receptorpotential vanilloid 1 (TRPV1) receptor, evoking chiefly neurogenic inflammation without inflammatory cellaccumulation. Intraplantar complete Freund's adjuvant (CFA; 50 ?l, 1mgml?1) also increased PACAP/PAC1 mRNAbut not the PACAP peptide. Capsaicin-induced neurogenic paw edema, but not CFA-evoked non-neurogenicswelling, was significantly smaller in PACAP-deficient mice throughout a 24-hour period. To our knowledge, weprovide previously unreported evidence for PACAP and PAC1 expression upregulation during skin inflammation ofdifferent mechanisms and for its pro-inflammatory function in neurogenic edema formation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
cross-talk
sebaceous gland
sebocytes
skin homeostasis
Megjelenés:Journal Of Investigative Dermatology 135 : 9 (2015), p. 2209-2218. -
További szerzők:Kun József Dobrosi Nóra (1981-) (molekuláris biológus) Sándor Katalin Németh József (1954-) (vegyész, analitikus) Perkecz Anikó Pintér Erika Szabadfi Krisztina (Pécsi Egyetem) Gaszner Balázs (Neuroanatómia) Tékus Valéria Szolcsányi János (Pécs) Steinhoff, Martin Hashimoto, Hitoshi Reglődi Dóra (Idegtudományok) Bíró Tamás (1968-) (élettanász)
Pályázati támogatás:OTKA-104984
OTKA
OTKA-PD100706
OTKA
OTKA-101761
OTKA
OTKA105369
OTKA
TÁMOP-4.2.2./A-11/1/KONV-2012-0025
TÁMOP
TÁMOP-4.2.4.A/ 2- 11/1-2012-0001
TÁMOP
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3.

001-es BibID:BIBFORM020034
Első szerző:Paus, Ralf
Cím:Frontiers in pruritus research : scratching the brain for more effective itch therapy / Ralf Paus, Martin Schmelz, Tamás Bíró, Martin Steinhoff
Dátum:2006
ISSN:0021-9738
Megjegyzések:This Review highlights selected frontiers in pruritus research and focuses on recently attained insights into the neurophysiological, neuroimmunological, and neuroendocrine mechanisms underlying skin-derived itch (pruritogenic pruritus), which may affect future antipruritic strategies. Special attention is paid to newly identified itch-specific neuronal pathways in the spinothalamic tract that are distinct from pain pathways and to CNS regions that process peripheral pruritogenic stimuli. In addition, the relation between itch and pain is discussed, with emphasis on how the intimate contacts between these closely related yet distinct sensory phenomena may be exploited therapeutically. Furthermore, newly identified or unduly neglected intracutaneous itch mediators (e.g., endovanilloids, proteases, cannabinoids, opioids, neurotrophins, and cytokines) and relevant receptors (e.g., vanilloid receptor channels and proteinase-activated, cannabinoid, opioid, cytokine, and new histamine receptors) are discussed. In summarizing promising new avenues for managing itch more effectively, we advocate therapeutic approaches that strive for the combination of peripherally active antiinflammatory agents with drugs that counteract chronic central itch sensitization.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Clinical Investigation. - 116 : 5 (2006), p. 1174-1185. -
További szerzők:Schmelz, Martin Bíró Tamás (1968-) (élettanász) Steinhoff, Martin
Internet cím:DOI
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4.

001-es BibID:BIBFORM020119
Első szerző:Steinhoff, Martin
Cím:Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus / Martin Steinhoff, John Bienenstock, Martin Schmelz, Marcus Maurer, Ed Wei, Tamás Bíró
Dátum:2006
ISSN:0022-202X
Megjegyzések:Pruritus (itch) can be defined as an unpleasant cutaneous sensation associated with the immediate desire to scratch. Recent findings have identified potential classes of endogenous "itch mediators" and establish a modern concept for the pathophysiology of pruritus. First, there in no universal peripheral itch mediator, but disease- specific sets of involved mediators. Second, numerous mediators of skin cells can activate and sensitize pruritic nerve endings, and even modulate their growth. Our knowledge of itch processing in the spinal cord and the involved centers in the central nervous system is rapidly growing. This review summarizes the current information about the significance of neuron - skin interactions, ion channels, neuropeptides, proteases, cannabinoids, opioids, kinins, cytokines, biogenic amines, neurotransmitters, and their receptors in the pathobiology of pruritus. A deeper understanding of these circuits is required for the development of novel antipruritic strategies.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Investigative Dermatology. - 126 : 8 (2006), p. 1705-1718. -
További szerzők:Bienenstock, John Schmelz, Martin Maurer, Marcus Wei, Ed Bíró Tamás (1968-) (élettanász)
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5.

001-es BibID:BIBFORM009115
Első szerző:Steinhoff, Martin
Cím:A TR(I)P to pruritus research : role of TRPV3 in inflammation and itch / Steinhoff, M., Bíró, T.
Dátum:2009
ISSN:0022-202X (Print)
Megjegyzések:Pruritus in eczema and other inflammatory skin diseases is an unsolved problem. Recent findings strongly indicate that histamine is not the only mediator of pruritus. Subtypes of the transient receptor potential (TRP) ion channel superfamily are expressed by sensory nerves, keratinocytes, and certain leukocytes. Temperature, pH changes, and certain toxins activate TRPs. New evidence indicates that the vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis, making it a good candidate for future therapy in skin inflammation and pruritus.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Body Temperature
Humans
Hydrogen-Ion Concentration
Inflammation
Keratinocytes
Leukocytes
Mice
Mice, Transgenic
Pruritus
Skin
TRPV Cation Channels
Transient Receptor Potential Channels
Megjelenés:The Journal of Investigative Dermatology. - 129 : 3 (2009), p. 531-535. -
További szerzők:Bíró Tamás (1968-) (élettanász)
Internet cím:DOI
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