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001-es BibID:BIBFORM048815
Első szerző:Langan, Ewan A.
Cím:Tumour necrosis factor alpha, interferon gamma and substance P are novel modulators of extrapituitary prolactin expression in human skin / Ewan A. Langan, Silvia Vidali, Natascha Pigat, Wolfgang Funk, Erika Lisztes, Tamás Bíró, Vincent Goffin, Christopher E. M. Griffiths, Ralf Paus
Dátum:2013
ISSN:1932-6203
Megjegyzések:Human scalp skin and hair follicles (HFs) are extra-pituitary sources of prolactin (PRL). However, the intracutaneous regulation of PRL remains poorly understood. Therefore we investigated whether well-recognized regulators of pituitary PRL expression, which also impact on human skin physiology and pathology, regulate expression of PRL and its receptor (PRLR) in situ. This was studied in serum-free organ cultures of microdissected human scalp HFs and skin, i.e. excluding pituitary, neural and vascular inputs. Prolactin expression was confirmed at the gene and protein level in human truncal skin, where its expression significantly increased (p?=?0.049) during organ culture. There was, however, no evidence of PRL secretion into the culture medium as measured by ELISA. PRL immunoreactivity (IR) in female human epidermis was decreased by substance P (p?=?0.009), while neither the classical pituitary PRL inhibitor, dopamine, nor corticotropin-releasing hormone significantly modulated PRL IR in HFs or skin respectively. Interferon (IFN) ? increased PRL IR in the epithelium of human HFs (p?=?0.044) while tumour necrosis factor (TNF) ? decreased both PRL and PRLR IR. This study identifies substance P, TNF? and IFN? as novel modulators of PRL and PRLR expression in human skin, and suggests that intracutaneous PRL expression is not under dopaminergic control. Given the importance of PRL in human hair growth regulation and its possible role in the pathogenesis of several common skin diseases, targeting intracutaneous PRL production via these newly identified regulatory pathways may point towards novel therapeutic options for inflammatory dermatoses.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:PLoS One. - 8 : 4 (2013), p. e60819. -
További szerzők:Vidali, Silvia Pigat, Natascha Funk, Wolfgang Lisztes Erika (1986-) (élettanász) Bíró Tamás (1968-) (élettanász) Goffin, Vincent Griffiths, Christopher E. M. Paus, Ralf
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2.

001-es BibID:BIBFORM041512
Első szerző:Langan, Ewan A.
Cím:Dopamine is a novel, direct inducer of catagen in human scalp hair follicles in vitro / E. A. Langan, E. Lisztes, T. Bíró, W. Funk, J. E. Kloepper, C. E. M. Griffiths, R. Paus
Dátum:2013
ISSN:0007-0963
Megjegyzések:Background? Although there are clinical reports of hair loss associated with levodopa and dopamine agonists, it is unclear whether dopamine exerts any direct effects on the human hair follicle (HF). Objectives? Given the widespread use of dopamine agonists and antagonists in clinical medicine, we sought to determine whether dopamine exerts direct effects on human HF growth and/or pigmentation in vitro, and whether human HFs express dopamine receptors (DRs). Methods? Microdissected human scalp HFs from women were treated in serum-free organ culture for 7?days with dopamine (10-1000?nmol?L(-1) ), and the effects on hair shaft production, HF cycling (i.e. anagen-catagen transition), hair matrix keratinocyte proliferation and apoptosis, and HF pigmentation were measured by quantitative (immuno-) histomorphometry. Results? Dopamine had no consistent effect on hair shaft production, but did promote HF regression (catagen). It was also associated with significantly reduced proliferation of HF matrix keratinocytes (P?<?0?01) and reduced intrafollicular melanin production. Dopamine receptor transcripts were identified in HFs and skin. Conclusions? These data provide evidence that dopamine is an inhibitor of human hair growth, via the promotion of catagen induction, at least in vitro. This may offer a rational explanation for the induction of telogen effluvium in some women treated with dopamine agonists such as bromocriptine. Moreover, dopaminergic agonists deserve further exploration as novel inhibitors of unwanted human hair growth (hirsutism, hypertrichosis)
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Dermatology. - 168 : 3 (2013), p. 520-525. -
További szerzők:Lisztes Erika (1986-) (élettanász) Bíró Tamás (1968-) (élettanász) Funk, W. Kloepper, Jennifer E. Griffiths, Christopher E. M. Paus, Ralf
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM016011
Első szerző:Langan, Ewan A.
Cím:Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro / Langan, E. A., Ramot, Y., Hanning, A., Poeggeler, B., Biro, T., Gaspar, E., Funk, W., Griffiths, C. E. M., Paus, R.
Dátum:2010
ISSN:0007-0963
Megjegyzések:Human skin and scalp hair follicles are both a nonclassical target and an extrapituitary source of prolactin (PRL), which is a potent hair growth modulator. However, how the expression of PRL and PRL receptor (PRLR) is regulated in human skin is unknown. Objectives To investigate whether two key stimulators of pituitary PRL secretion, thyrotropin-releasing hormone (TRH) and oestrogen, also regulate cutaneous PRL and PRLR expression. Methods Female scalp skin and/or microdissected hair follicles were treated for 6 days in serum-free organ culture with oestrogen (100 nmol L-1), TRH (1-10 ng mL-1, 3-30 nm) or vehicle control. Quantitative immunohistomorphometry of skin and hair follicle sections was complemented with quantitative polymerase chain reaction for PRL and PRLR in cultured hair follicles and/or female human outer root sheath (ORS) keratinocytes. Results Oestrogen treatment significantly upregulated PRL and PRLR immunoreactivity in selected skin and hair follicle compartments, at the gene and protein level (P < 0 center dot 05). TRH significantly increased PRL immunoreactivity and transcription in hair follicles (P < 0 center dot 05); however, while it also increased PRLR transcription in hair follicles, it downregulated PRLR immunoreactivity in the hair follicle ORS (P < 0 center dot 05). Conclusions Our pilot study shows that two key endocrine controls of pituitary PRL secretion, oestrogen and TRH, also regulate PRL and PRLR expression in human skin. This provides novel insights into the regulation of extrapituitary PRL and PRLR expression, and invites exploration of oestrogen and TRH as novel therapeutic agents in the management of skin and hair diseases characterized by aberrant PRLR-mediated signalling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Dermatology. - 162 : 5 (2010), p. 1127-1131. -
További szerzők:Ramot, Yuval Hanning, A. Poeggeler, Burkhard Bíró Tamás (1968-) (élettanász) Gáspár E. Funk, W. Griffiths, Christopher E. M. Paus, Ralf
Internet cím:DOI
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4.

001-es BibID:BIBFORM014368
Első szerző:Ramot, Yuval
Cím:Prolactin - a novel neuroendocrine regulator of human keratin expression in situ / Yuval Ramot, Tamás Bíró, Stephan Tiede, Balázs I. Tóth, Ewan A. Langan, Koji Sugawara, Kerstin Foitzik, Arieh Ingber, Vincent Goffin, Lutz Langbein, Ralf Paus
Dátum:2010
ISSN:0892-6638
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
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Megjelenés:The FASEB Journal. - 24 : 6 (2010), p. 1768-1779. -
További szerzők:Bíró Tamás (1968-) (élettanász) Tiede, Stephan Tóth István Balázs (1978-) (élettanász) Langan, Ewan A. Sugawara, Koji Foitzik, Kerstin Ingber, Arieh Goffin, Vincent Langbein, Lutz Paus, Ralf
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