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001-es BibID:	BIBFORM055571
Első szerző:	Fischer, T. W.
Cím:	Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and TGF-β2-/IGF-1-mediated regulation of hair cycle in male and female human hair follicles in vitro / T. W. Fischer, E. Herczeg-Lisztes, W. Funk, D. Zillikens, T. Bíró, R. Paus
Dátum:	2014
ISSN:	0007-0963
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	British Journal of Dermatology. - 171 : 5 (2014), p. 1031-1043. -
További szerzők:	Lisztes Erika (1986-) (élettanász) Funk, W. Zillikens, D. Bíró Tamás (1968-) (élettanász) Paus, Ralf
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM041512
Első szerző:	Langan, Ewan A.
Cím:	Dopamine is a novel, direct inducer of catagen in human scalp hair follicles in vitro / E. A. Langan, E. Lisztes, T. Bíró, W. Funk, J. E. Kloepper, C. E. M. Griffiths, R. Paus
Dátum:	2013
ISSN:	0007-0963
Megjegyzések:	Background? Although there are clinical reports of hair loss associated with levodopa and dopamine agonists, it is unclear whether dopamine exerts any direct effects on the human hair follicle (HF). Objectives? Given the widespread use of dopamine agonists and antagonists in clinical medicine, we sought to determine whether dopamine exerts direct effects on human HF growth and/or pigmentation in vitro, and whether human HFs express dopamine receptors (DRs). Methods? Microdissected human scalp HFs from women were treated in serum-free organ culture for 7?days with dopamine (10-1000?nmol?L(-1) ), and the effects on hair shaft production, HF cycling (i.e. anagen-catagen transition), hair matrix keratinocyte proliferation and apoptosis, and HF pigmentation were measured by quantitative (immuno-) histomorphometry. Results? Dopamine had no consistent effect on hair shaft production, but did promote HF regression (catagen). It was also associated with significantly reduced proliferation of HF matrix keratinocytes (P?<?0?01) and reduced intrafollicular melanin production. Dopamine receptor transcripts were identified in HFs and skin. Conclusions? These data provide evidence that dopamine is an inhibitor of human hair growth, via the promotion of catagen induction, at least in vitro. This may offer a rational explanation for the induction of telogen effluvium in some women treated with dopamine agonists such as bromocriptine. Moreover, dopaminergic agonists deserve further exploration as novel inhibitors of unwanted human hair growth (hirsutism, hypertrichosis)
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	British Journal of Dermatology. - 168 : 3 (2013), p. 520-525. -
További szerzők:	Lisztes Erika (1986-) (élettanász) Bíró Tamás (1968-) (élettanász) Funk, W. Kloepper, Jennifer E. Griffiths, Christopher E. M. Paus, Ralf
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM016011
Első szerző:	Langan, Ewan A.
Cím:	Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro / Langan, E. A., Ramot, Y., Hanning, A., Poeggeler, B., Biro, T., Gaspar, E., Funk, W., Griffiths, C. E. M., Paus, R.
Dátum:	2010
ISSN:	0007-0963
Megjegyzések:	Human skin and scalp hair follicles are both a nonclassical target and an extrapituitary source of prolactin (PRL), which is a potent hair growth modulator. However, how the expression of PRL and PRL receptor (PRLR) is regulated in human skin is unknown. Objectives To investigate whether two key stimulators of pituitary PRL secretion, thyrotropin-releasing hormone (TRH) and oestrogen, also regulate cutaneous PRL and PRLR expression. Methods Female scalp skin and/or microdissected hair follicles were treated for 6 days in serum-free organ culture with oestrogen (100 nmol L-1), TRH (1-10 ng mL-1, 3-30 nm) or vehicle control. Quantitative immunohistomorphometry of skin and hair follicle sections was complemented with quantitative polymerase chain reaction for PRL and PRLR in cultured hair follicles and/or female human outer root sheath (ORS) keratinocytes. Results Oestrogen treatment significantly upregulated PRL and PRLR immunoreactivity in selected skin and hair follicle compartments, at the gene and protein level (P < 0 center dot 05). TRH significantly increased PRL immunoreactivity and transcription in hair follicles (P < 0 center dot 05); however, while it also increased PRLR transcription in hair follicles, it downregulated PRLR immunoreactivity in the hair follicle ORS (P < 0 center dot 05). Conclusions Our pilot study shows that two key endocrine controls of pituitary PRL secretion, oestrogen and TRH, also regulate PRL and PRLR expression in human skin. This provides novel insights into the regulation of extrapituitary PRL and PRLR expression, and invites exploration of oestrogen and TRH as novel therapeutic agents in the management of skin and hair diseases characterized by aberrant PRLR-mediated signalling.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	British Journal of Dermatology. - 162 : 5 (2010), p. 1127-1131. -
További szerzők:	Ramot, Yuval Hanning, A. Poeggeler, Burkhard Bíró Tamás (1968-) (élettanász) Gáspár E. Funk, W. Griffiths, Christopher E. M. Paus, Ralf
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM020341
Első szerző:	Ramot, Yuval
Cím:	TSH is a novel neuroendocrine regulator of selected keratins in the human hair follicle / Ramot Y., Zhang G., Biro T., Lisztes E., Funk W., Ingber A., Langbein L., Paus R.
Dátum:	2011
ISSN:	1873-569X (Electronic)
Tárgyszavak:	Orvostudományok Elméleti orvostudományok szerkesztői levél
Megjelenés:	Journal of Dermatological Science 64 : 1 (2011), p. 67-70. -
További szerzők:	Zhang, Guoyou Bíró Tamás (1968-) (élettanász) Lisztes Erika (1986-) (élettanász) Funk, W. Ingber, Arieh Langbein, Lutz Paus, Ralf
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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