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001-es BibID:	BIBFORM070473
035-os BibID:	(WoS)000385353200010 (Scopus)84983551225
Első szerző:	Oláh Attila (élettanász)
Cím:	Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment / Oláh Attila, Markovics Arnold, Szabó-Papp Judit, Szabó Pálma Tímea, Stott Colin, Zouboulis Christos C., Bíró Tamás
Dátum:	2016
ISSN:	0906-6705
Megjegyzések:	Acne is a common skin disease characterized by elevatedsebum production and inflammation of the sebaceous glands. Wehave previously shown that a non-psychotropic phytocannabinoid((?)-cannabidiol [CBD]) exerted complex anti-acne effects bynormalizing ♭pro-acne agents'-induced excessive sebaceous lipidproduction, reducing proliferation and alleviating inflammation inhuman SZ95 sebocytes. Therefore, in this study we aimed to explorethe putative anti-acne effects of further non-psychotropic phytocannabinoids((?)-cannabichromene [CBC], (?)-cannabidivarin[CBDV], (?)-cannabigerol [CBG], (?)-cannabigerovarin [CBGV]and (?)-D9-tetrahydrocannabivarin [THCV]). Viability andproliferation of human SZ95 sebocytes were investigated by MTTand CyQUANT assays; cell death and lipid synthesis weremonitored by DilC1(5)-SYTOX Green labelling and Nile Redstaining, respectively. Inflammatory responses were investigated bymonitoring expressions of selected cytokines uponlipopolysaccharide treatment (RT-qPCR, ELISA). Up to 10 lM, thephytocannabinoids only negligibly altered the viability of thesebocytes, whereas high doses (?50 lM) induced apoptosis.Interestingly, basal sebaceous lipid synthesis was differentiallymodulated by the substances: CBC and THCV suppressed it, andCBDV had only minor effects, whereas CBG and CBGV increased it.Importantly, CBC, CBDV and THCV significantly reducedarachidonic acid (AA)-induced ♭acne-like' lipogenesis. Moreover,THCV suppressed proliferation, and all phytocannabinoids exertedremarkable anti-inflammatory actions. Our data suggest that CBGand CBGV may have potential in the treatment of dry-skinsyndrome, whereas CBC, CBDV and especially THCV showpromise to become highly efficient, novel anti-acne agents.Moreover, based on their remarkable anti-inflammatory actions,phytocannabinoids could be efficient, yet safe novel tools in themanagement of cutaneous inflammations.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk acne vulgaris cutaneous inflammation dry skin phytocannabinoid
Megjelenés:	Experimental Dermatology. - 25 : 9 (2016), p. 701-707. -
További szerzők:	Markovics Arnold (1988-) (molekuláris biológus) Papp Judit (élettanász) Szabó Pálma Stott, Colin Zouboulis, Christos C. (1960-) (bőrgyógyász) Bíró Tamás (1968-) (élettanász)
Pályázati támogatás:	Lendület LP2011-003/ 2015 Egyéb TÁMOP-4.2.4.A/2-11-1-2012-0001 TÁMOP OTKA 101761 Egyéb OTKA 105368 Egyéb TÁMOP-4.2.2-08/1/2008-0019 Egyéb FP7-REGPOT-2008-1/229920 Egyéb
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001-es BibID:	BIBFORM070475
Első szerző:	Oláh Attila (élettanász)
Cím:	Echinacea purpurea-derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema / Oláh Attila, Szabó-Papp Judit, Soeberdt Michael, Knie Ulrich, Dähnhardt-Pfeiffer Stephan, Abels Christoph, Bíró Tamás
Dátum:	2017
ISSN:	0923-1811 1873-569X
Megjegyzések:	Background: Atopic eczema (AE) is a chronic inflammatory and pruritic skin disease. There is still anunmet need for topical anti-inflammatory and anti-pruritic substances exhibiting an excellent safetyprofile. The endocannabinoid system is known to regulate various aspects of cutaneous barrier andimmune functions, thus targeting it may be a valid approach for alleviating the symptoms of AE.Objective: To assess the putative efficacy of Echinacea purpurea-derived alkylamides (Ec. extract)activating cannabinoid (CB)-2 receptors in exerting anti-inflammatory effects and alleviating symptomsof AE.Methods: In vitro anti-inflammatory efficiency was investigated by monitoring the effects of Ec. extract onpoly-(I:C)-induced pro-inflammatory cytokine expression (Q-PCR) and release (ELISA) of HaCaTkeratinocytes. Irritancy and sensitization potential (assessed by Human Repeat Insult Patch Test;Clinical trial 1); clinical efficiency in alleviating symptoms of AE (Clinical trial 2) as well as effects onhuman skin structure and lipid content (Clinical trial 3 followed by transmission electron microscopy andHPTLC) were investigated in randomized double blind clinical trials.Results: Ec. extract significantly reduced mRNA expression as well as release of poly-(I:C)-induced proinflammatorycytokines (IL-6 and IL-8) in keratinocytes. Thus, not surprisingly, the well-tolerated(Clinical trial 1) Ec. extract-based cream reduced local SCORAD statistically significantly, not onlycompared to baseline, but also compared to the comparator (Clinical trial 2). Of great importance, besidesthe in vitro anti-inflammatory effects, administration of the Ec. extract-based cream also resulted insignificantly higher levels of overall epidermal lipids, ceramide EOS (v-esterified fatty acid + sphingosinesphingoid base), and cholesterol at Day 15 compared to baseline as well as significantly greater numbersof intercellular lipid lamellae in the intercellular space (Clinical trial 3).Conclusion: The investigated Ec. extract shows great potential in alleviating cutaneous symptoms of AE,and by exerting remarkable anti-inflammatory actions and restoring the epidermal lipid barrier, it will bevery likely a well-tolerated, powerful novel ingredient for the adjuvant therapy of AE.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Echinacea purpurea Atopic eczema Endocannabinoid system Inflammation Skin barrier
Megjelenés:	Journal Of Dermatological Science 88 : 1 (2017), p. 67-77. -
További szerzők:	Papp Judit (élettanász) Soeberdt, Michael Knie, Ulrich Dähnhardt-Pfeiffer, Stephan Abels, Christoph Bíró Tamás (1968-) (élettanász)
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001-es BibID:	BIBFORM067334
035-os BibID:	(WoS)000393908000018 (Scopus)85006279500
Első szerző:	Szöllősi Attila Gábor (élettanász)
Cím:	Bifidobacterium longum extract exerts pro-differentiating effects on human epidermal keratinocytes, in vitro / Szöllősi A. G., Gueniche A., Jammayrac O., Szabó-Papp J., Blanchard C., Vasas N., Andrási M., Juhász I., Breton L., Bíró T.
Dátum:	2017
ISSN:	0906-6705
Tárgyszavak:	Orvostudományok Elméleti orvostudományok levél folyóiratcikk
Megjelenés:	Experimental Dermatology. - 26 : 1 (2017), p. 92-94. -
További szerzők:	Gueniche, Audrey Jammayrac, Odette Papp Judit (élettanász) Blanchard, Carine Molnárné Vasas Nikolett (1987-) (élettanász) Andrási Mónika Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus) Breton, Lionel Bíró Tamás (1968-) (élettanász)
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