Találati lista | Tudóstér

001-es BibID:	BIBFORM039248
Első szerző:	Conrad, Franziska
Cím:	Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding / Conrad Franziska, Ohnemus Ulrich, Bodo Eniko, Biro Tamas, Tychsen Birte, Gerstmayer Bernhard, Bosio Andreas, Schmidt-Rose Thomas, Altgilbers Silke, Bettermann Albrecht, Saathoff Matthias, Meyer Wilfried, Paus Ralf
Dátum:	2005
ISSN:	1087-0024
Megjegyzések:	In this study, it was investigated how estrogens (17-beta-estradiol, E2) affect the estrogen receptor (ER) expression and gene regulation of male versus female human scalp hair follicles in vitro. Anagen VI follicles from frontotemporal scalp skin were microdissected and organ-cultured for up to 9 d in the presence of E2 (1-100 nm). Immunohistochemistry was performed for ERbeta-expression, known to be predominant in human scalp hair follicles, and for TGF-beta2-expression (as negative key hair growth modulator), and E2-responsive genes in organ-cultured human scalp hair follicles (48 h, 10 nM) were explored by cDNA microarray, using a commercial skin focus chip (Memorec, Cologne, Germany). The distribution pattern of ERbeta and TGF-beta2-immunoreactivity differed between male and female hair follicles after 48 h culture. Of 1300 genes tested, several genes were regulated sex-dependent differently. The study reveals substantial sex-dependent differences in the response of frontotemporal human scalp hair follicles to E2. Recognition and systematic dissection of the E2-dependent gene regulation will be crucial for the development of more effective, gender-tailored management strategies for female versus male pattern balding.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Investigative Dermatology Symposium Proceedings. - 10 : 3 (2005), p. 243-246. -
További szerzők:	Ohnemus, Ulrich Bodó Enikő Bíró Tamás (1968-) (élettanász) Tychsen, Birte Gerstmayer, Bernhard Bosio, Andreas Schmidt-Rose, Thomas Altgilbers, Silke Bettermann, Albrecht Saathoff, Matthias Meyer, Wilfried Paus, Ralf
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: