Találati lista | Tudóstér

001-es BibID:	BIBFORM048834
035-os BibID:	PMID:24005054
Első szerző:	Al-Nuaimi, Yusur
Cím:	A meeting of two chronobiological systems : circadian proteins period1 and BMAL1 modulate the human hair cycle clock / Yusur Al-Nuaimi, Jonathan A. Hardman, Tamás Bíró, Iain S. Haslam, Michael P. Philpott, Balázs I. Tóth, Nilofer Farjo, Bessam Farjo, Gerold Baier, Rachel E. B. Watson, Benedetto Grimaldi, Jennifer E. Kloepper, Ralf Paus
Dátum:	2014
ISSN:	0022-202X
Megjegyzések:	The hair follicle (HF) is a continuously remodeled mini organ that cycles between growth (anagen), regression (catagen), and relative quiescence (telogen). As the anagen-to-catagen transformation of microdissected human scalp HFs can be observed in organ culture, it permits the study of the unknown controls of autonomous, rhythmic tissue remodeling of the HF, which intersects developmental, chronobiological, and growth-regulatory mechanisms. The hypothesis that the peripheral clock system is involved in hair cycle control, i.e., the anagen-to-catagen transformation, was tested. Here we show that in the absence of central clock influences, isolated, organ-cultured human HFs show circadian changes in the gene and protein expression of core clock genes (CLOCK, BMAL1, and Period1) and clock-controlled genes (c-Myc, NR1D1, and CDKN1A), with Period1 expression being hair cycle dependent. Knockdown of either BMAL1 or Period1 in human anagen HFs significantly prolonged anagen. This provides evidence that peripheral core clock genes modulate human HF cycling and are an integral component of the human hair cycle clock. Specifically, our study identifies BMAL1 and Period1 as potential therapeutic targets for modulating human hair growth.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Calcium (Ca2+) signalling Ion channel Membrane transport Molecular mechanisms of disease Skin TRP channels
Megjelenés:	Journal of Investigative Dermatology 134 : 3 (2014), p. 610-619. -
További szerzők:	Hardman, Jonathan A. Bíró Tamás (1968-) (élettanász) Haslam, Iain S. Philpott, Michael P. Tóth István Balázs (1978-) (élettanász) Farjo, Nilofer Farjo, Bessam Baier, Gerold Watson, Rachel E. B. Grimaldi, Benedetto Kloepper, Jennifer E. Paus, Ralf
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM072426
035-os BibID:	(WOS)000392469700009 (Scopus)85010461576
Első szerző:	Haslam, Iain S.
Cím:	Oxidative Damage Control in a Human (Mini-) Organ : Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition / Iain S. Haslam, Laura Jadkauskaite, Imre Lorinc Szabo, Selma Staege, Jasper Hesebeck-Brinckmann, Gail Jenkins, Ranjit K. Bhogal, Fei-Ling Lim, Nilofer Farjo, Bessam Farjo, Tamás Bíró, Matthias Schäfer, Ralf Paus
Dátum:	2017
ISSN:	0022-202X 1523-1747
Megjegyzések:	The in situ control of redox insult in human organs is of major clinical relevance, yet remains incompletely understood. Activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the "master regulator" of genes controlling cellular redox homeostasis, is advocated as a therapeutic strategy for diseases with severely impaired redox balance. It remains to be shown whether this strategy is effective in human organs, rather than only in isolated human cell types. We have therefore explored the role of Nrf2 in a uniquely accessible human (mini-) organ: scalp hair follicles. Microarray and qRT-PCR analysis of human hair follicles after Nrf2 activation using sulforaphane identified the modulation of phase II metabolism, reactive oxygen species clearance, the pentose phosphate pathway, and glutathione homeostasis. Nrf2 knockdown (small interfering RNA) in cultured human hair follicles confirmed the regulation of key Nrf2 target genes (i.e., heme oxygenase-1, NAD(P)H dehydrogenase, quinone 1, glutathione reductase, glutamate-cysteine ligase catalytic subunit, ABCC1, peroxiredoxin 1). Importantly, Nrf2 activation significantly reduced reactive oxygen species levels and associated lipid peroxidation. Nrf2 preactivation reduced premature catagen and hair growth inhibition induced by oxidative stress (H2O2 or menadione), significantly ameliorated the H2O2-dependent increase in matrix keratinocyte apoptosis and reversed the reactive oxygen species-induced reduction in hair matrix proliferation. This study thus provides direct evidence for the crucial role of Nrf2 in protecting human organ function (i.e., scalp hair follicles) against redox insult.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk DERMAL PAPILLA CELLS IN-VITRO MITOCHONDRIAL-FUNCTION FOLLICLE PIGMENTATIONE PARKINSONS-DISEASE CYCLOSPORINE-A CANCER CELLS CHEMOTHERAPY CATAGEN SULFORAPHANE
Megjelenés:	Journal Of Investigative Dermatology. - 137 : 2 (2017), p. 295-304. -
További szerzők:	Jadkauskaite, Laura Szabó Imre Lőrinc (1987-) (általános orvos) Staege, Selma Hesebeck-Brinckmann, Jasper Jenkins, Gail Bhogal, Ranjit K. Lim, Fei-Ling Farjo, Nilofer Farjo, Bessam Bíró Tamás (1968-) (élettanász) Schäfer, Matthias Paus, Ralf
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: