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001-es BibID:	BIBFORM054575
035-os BibID:	PMID: 24927567
Első szerző:	Iannotti, Fabio A.
Cím:	The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels / Fabio A. Iannotti, Cristoforo Silvestri, Enrico Mazzarella, Andrea Martella, Daniela Calvigioni, Fabiana Piscitelli, Paolo Ambrosino, Stefania Petrosino, Gabriella Czifra, Tamás Bíró, Tibor Harkany, Maurizio Taglialatela, Vincenzo Di Marzo
Dátum:	2014
ISSN:	0027-8424
Megjegyzések:	Little is known of the involvement of endocannabinoids and cannabinoid receptors in skeletal muscle cell differentiation. We report that, due to changes in the expression of genes involved in its metabolism, the levels of the endocannabinoid 2-arachidonoylglycerol (2-AG) are decreased both during myotube formation in vitro from murine C2C12 myoblasts and during mouse muscle growth in vivo. The endocannabinoid, as well as the CB1 agonist arachidonoyl-2-chloroethylamide, prevent myotube formation in a manner antagonized by CB1 knockdown and by CB1 antagonists, which, per se, instead stimulate differentiation. Importantly, 2-AG also inhibits differentiation of primary human satellite cells. Muscle fascicles from CB1 knockout embryos contain more muscle fibers, and postnatal mice show muscle fibers of an increased diameter relative to wild-type littermates. Inhibition of Kv7.4 channel activity, which plays a permissive role in myogenesis and depends on phosphatidylinositol 4,5-bisphosphate (PIP2), underlies the effects of 2-AG. We find that CB1 stimulation reduces both total and Kv7.4-bound PIP2 levels in C2C12 cells and inhibits Kv7.4 currents in transfected CHO cells. We suggest that 2-AG is an endogenous repressor of myoblast differentiation via CB1-mediated inhibition of Kv7.4 channels.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Proceedings of the National Academy of Sciences of the United States of America. - 111 : 24 (2014), p. 2472-2481. -
További szerzők:	Silvestri, Cristoforo Mazzarella, Enrico Martella, Andrea Calvigioni, Daniela Piscitelli, Fabiana Ambrosino, Paolo Petrosino, Stefania Czifra Gabriella (1975-) (élettanász) Bíró Tamás (1968-) (élettanász) Harkány Tibor Taglialatela, Maurizio Di Marzo, Vincenzo
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM072830
035-os BibID:	(WOS)000439136200018 (Scopus)85046719619
Első szerző:	Zákány Nóra
Cím:	Endocannabinoid tone regulates human sebocyte biology / Nóra Zákány, Attila Oláh, Arnold Markovics, Erika Takács, Andrea Aranyász, Simon Nicolussi, Fabiana Piscitelli, Marco Allarà, Ágnes Pór, Ilona Kovács, Christos C. Zouboulis, Jürg Gertsch, Vincenzo Di Marzo, Tamás Bíró, Tamás Szabó
Dátum:	2018
ISSN:	0022-202X 1523-1747
Megjegyzések:	We have previously shown that i) endocannabinoids (eCB; e.g. anandamide [AEA]) are involved in the maintenance of homeostatic sebaceous lipid production (SLP) in human sebaceous glands (SG); and ii) eCB treatment dramatically increases SLP. Here, we aimed to investigate the expression of the major eCB synthesizing and degrading enzymes, and to study the effects of eCB uptake inhibitors on human SZ95 sebocytes, thus exploring the role of the putative eCB membrane transporter (EMT), which has been hypothesized to facilitate the cellular uptake and subsequent degradation of eCBs.We found that the major eCB synthesizing (NAPE-PLD, DAGL? and -?) and degrading (FAAH, MAGL) enzymes are expressed in SZ95 sebocytes, and also in SGs (except for DAGL?, whose staining was dubious in histological preparations). Interestingly, eCB uptake-inhibition with VDM11 induced a moderate increase in SLP, and also elevated the levels of various eCBs and related acylethanolamides. Finally, we found that VDM11 was able to interfere with the pro-inflammatory action of the Toll-like receptor 4 activator lipopolysaccharide.Collectively, our data suggest that inhibition of eCB uptake exerts anti-inflammatory actions and elevates both SLP and eCB levels; thus, these inhibitors might be beneficial in cutaneous inflammatory conditions accompanied by dry skin.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk xylitol
Megjelenés:	Journal of Investigative Dermatology. - 138 : 8 (2018), p. 1699-1706. -
További szerzők:	Oláh Attila (1984-) (élettanász) Markovics Arnold (1988-) (molekuláris biológus) Takács Erika (1987-) (biológus) Aranyász Andrea Nicolussi, Simon Piscitelli, Fabiana Allarà, Marco Pór Ágnes Kovács Ilona (1965-) (patológus) Zouboulis, Christos C. (1960-) (bőrgyógyász) Gertsch, Jürg Di Marzo, Vincenzo Bíró Tamás (1968-) (élettanász) Szabó Tamás
Pályázati támogatás:	Lendület LP2011-003/2015 MTA GINOP-2.3.2-15-2016-00015 GINOP TÁMOP-4.2.4.A/2-11-1-2012-0001 TÁMOP 120552 OTKA 121360 OTKA 125055 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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