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001-es BibID:	BIBFORM072428
035-os BibID:	(WoS)000394755100030 (Scopus)85010777987
Első szerző:	Szabó K.
Cím:	Factors shaping the composition of the cutaneous microbiota / K. Szabo, L. Erdei, B. Sz. Bolla, G. Tax, T. Bíró, L. Kemeny
Dátum:	2017
ISSN:	0007-0963 1365-2133
Megjegyzések:	From birth, we are constantly exposed to bacteria, fungi and viruses, some of which are capable of transiently or permanently inhabiting our different body parts as our microbiota. The majority of our microbial interactions occur during and after birth, and several different factors, including age, sex, genetic constitution, environmental conditions and lifestyle, have been suggested to shape the composition of this microbial community. Propionibacterium acnes is one of the most dominant lipophilic microbes of the postadolescent, sebum-rich human skin regions. Currently, the role of this bacterium in the pathogenesis of the most common inflammatory skin disease, acne vulgaris, is a topic of intense scientific debate. Recent results suggest that Westernization strongly increases the dominance of the Propionibacterium genus in human skin compared with natural populations living more traditional lifestyles. According to the disappearing microbiota hypothesis proposed by Martin Blaser, such alterations in the composition of our microbiota are the possible consequences of socioeconomic and lifestyle changes occurring after the industrial revolution. Evanescence of species that are important elements of the human ecosystem might lead to the overgrowth and subsequent dominance of others because of the lack of ecological competition. Such changes can disturb the fine-tuned balance of the human body and, accordingly, our microbes developed through a long co-evolutionary process. These processes might lead to the transformation of a seemingly harmless species into an opportunistic pathogen through bacterial dysbiosis. This might have happened in the case of P. acnes in acne pathogenesis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk PROPIONIBACTERIUM-ACNES BIOFILMS HUMAN SKIN MICROBIOME VERNIX CASEOSA SEBACEOUS GLAND AGE VULGARIS DISEASES BARRIER PREVALENCE RESISTANCE
Megjelenés:	British Journal of Dermatology. - 176 : 2 (2017), p. 344-351. -
További szerzők:	Erdei László (Szeged) Bolla B. Sz. (Szeged) Tax, Gábor Bíró Tamás (1968-) (élettanász) Kemény Lajos V. (bőrgyógyász Szeged)
Pályázati támogatás:	OTKA NK105369 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM061063
Első szerző:	Tax, Gábor
Cím:	Propionic Acid Produced by Propionibacterium acnes Strains Contri-butes to Their Pathogenicity / Gábor Tax, Edit Urbán, Zsuzsanna Palotás, Róbert Puskás, Zoltán Kónya, Tamás Bíró, Lajos Kemény, Kornélia Szabó
Dátum:	2016
ISSN:	0001-5555
Megjegyzések:	Propionibacterium acnes is an important member of theskin microbiome. The bacterium can initiate signallingevents and changes in cellular properties in keratinocytes.The aim of this study was to analyse the effect ofthe bacterium on an immortalized human keratinocytecell line. The results show that various P. acnes strainsaffect the cell-growth properties of these cells differentially,inducing cytotoxicity in a strain-specific and dosedependentmanner. We propose that bacterially secretedpropionic acid may contribute to the cytotoxic effect.This acid has a role in maintaining skin pH and exhibitsantimicrobial properties, but may also have deleteriouseffects when the local concentration rises due to excessivebacterial growth and metabolism. These results, togetherwith available data from the literature, may provide insightinto the dual role of P. acnes in healthy skin andduring pathogenic conditions, as well as the key moleculesinvolved in these functions. Key words: immortalizedkeratinocyte cell line (HPV-KER); Propionibacterium acnes;acne vulgaris; short-chain fatty acid; propionic acid.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban immortalized keratinocyte cell line (HPV-KER) Propionibacterium acnes acne vulgaris short-chain fatty acid propionic acid
Megjelenés:	Acta Dermato-Venereologica. - 96 : 1 (2016), p. 43-49. -
További szerzők:	Urbán Edit Palotás Zsuzsanna Puskás Róbert Kónya Zoltán (Szeged) Bíró Tamás (1968-) (élettanász) Kemény Lajos Szabó Kornélia
Pályázati támogatás:	OTKA-NK105369 OTKA TÁMOP-4.2.2.A-11/1/KONV-2012-0035 TÁMOP TÁMOP-4.2.4.A/2-11/1-2012-0001 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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