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1.

001-es BibID:BIBFORM020120
Első szerző:Bíró Tamás (élettanász)
Cím:Hair cycle control by vanilloid receptor-1 (TRPV1) : evidence from TRPV1 knockout mice / Tamás Bíró, Enikő Bodó, Andrea Telek, Tamás Géczy, Birte Tychsen, László Kovács, Ralf Paus
Dátum:2006
ISSN:0022-202X
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Investigative Dermatology. - 126 : 8 (2006), p. 1909-1912. -
További szerzők:Bodó Enikő Telek Andrea (1977-) (élettanász) Géczy Tamás (1980-) (élettanász) Tychsen, Birte Kovács László Paus, Ralf
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2.

001-es BibID:BIBFORM016014
Első szerző:Bodó Enikő
Cím:Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones / Bodo, E., Kany, B., Gaspar, E., Knuver, J., Kromminga, A., Ramot, Y., Biro, T., Tiede, S., van Beek, N., Poeggeler, B., Meyer, K. C., Wenzel, B. E., Paus, R.
Dátum:2010
ISSN:0013-7227
Megjegyzések:Several elements of the hypothalamic-pituitary-thyroid axis (HPT) reportedly are transcribed by human skin cell populations, and human hair follicles express functional receptors for TSH. Therefore, we asked whether the epidermis of normal human skin is yet another extrathyroidal target of TSH and whether epidermis even produces TSH. If so, we wanted to clarify whether intraepidermal TSH expression is regulated by TRH and/or thyroid hormones and whether TSH alters selected functions of normal human epidermis in situ. TSH and TSH receptor (TSH-R) expression were analyzed in the epidermis of normal human scalp skin by immunohistochemistry and PCR. In addition, full-thickness scalp skin was organ cultured and treated with TSH, TRH, or thyroid hormones, and the effect of TSH treatment on the expression of selected genes was measured by quantitative PCR and/or quantitative immunohistochemistry. Here we show that normal human epidermis expresses TSH at the mRNA and protein levels in situ and transcribes TSH-R. It also contains thyrostimulin transcripts. Intraepidermal TSH immunoreactivity is up-regulated by TRH and down-regulated by thyroid hormones. Although TSH-R immunoreactivity in situ could not be documented within the epidermis, but in the immediately adjacent dermis, TSH treatment of organ-cultured human skin strongly up-regulated epidermal expression of involucrin, loricrin, and keratins 5 and 14. Thus, normal human epidermis in situ is both an extrapituitary source and (possibly an indirect) target of TSH signaling, which regulates defined epidermal parameters. Intraepidermal TSH expression appears to be regulated by the classical endocrine controls that determine the systemic HPT axis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrinology. - 151 : 4 (2010), p. 1633-1642. -
További szerzők:Kany Benedikt Gáspár Erzsébet Knüver, Jana Kromminga, Arno Ramot, Yuval Bíró Tamás (1968-) (élettanász) Tiede, Stephan van Beek, Nina Poeggeler, Burkhard Meyer, Katja C. Wenzel, Björn E. Paus, Ralf
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3.

001-es BibID:BIBFORM014374
Első szerző:Bodó Enikő
Cím:A Hot New Twist to Hair Biology : involvement of Vanilloid Receptor-1 (VR1/TRPV1) Signaling in Human Hair Growth Control / Enikő Bodó, Tamás Bíró, Andrea Telek, Gabriella Czifra, Zoltán Griger, Balázs I. Tóth, Alessandra Mescalchin, Taisuke Ito, Albrecht Bettermann, László Kovács, Ralf Paus
Dátum:2005
ISSN:0002-9440
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Pathology 166 : 4 (2005), p. 985-998. -
További szerzők:Bíró Tamás (1968-) (élettanász) Telek Andrea (1977-) (élettanász) Czifra Gabriella (1975-) (élettanász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Tóth István Balázs (1978-) (élettanász) Mescalchin, Alessandra Ito, Taisuke Bettermann, Albrecht Kovács László (1939-) (élettanász) Paus, Ralf
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4.

001-es BibID:BIBFORM009197
Első szerző:Bodó Enikő
Cím:Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone / Bodo, E., Kromminga, A., Biro, T., Borbiro, I., Gaspar, E., Zmijewski, M. A., van Beek, N., Langbein, L., Slominski, A. T., Paus, R.
Dátum:2009
ISSN:1523-1747 (Electronic)
Megjegyzések:Pituitary thyroid-stimulating hormone (TSH) regulates thyroid hormone synthesis via receptors (TSH-R) expressed on thyroid epithelial cells. As the hair follicle (HF) is uniquely hormone-sensitive and, hypothyroidism with its associated, increased TSH serum levels clinically can lead to hair loss, we asked whether human HFs are a direct target for TSH. Here, we report that normal human scalp skin and microdissected human HFs express TSH-R mRNA. TSH-R-like immunoreactivity is limited to the mesenchymal skin compartments in situ. TSH may alter HF mesenchymal functions, as it upregulates alpha-smooth muscle actin expression in HF fibroblasts. TSH-R stimulation by its natural ligand in organ culture changes the expression of several genes of human scalp HFs (for example keratin K5), upregulates the transcription of classical TSH target genes and enhances cAMP production. Although the functional role of TSH in human HF biology awaits further dissection, these findings document that intracutaneous TSH-Rs are fully functional in situ and that HFs of female individuals are direct targets for nonclassical, extrathyroidal TSH bioregulation. This suggests that organ-cultured scalp HFs provide an instructive and physiologically relevant human model for exploring nonclassical functions of TSH, in and beyond the skin.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Actins
Cell Proliferation
Cells, Cultured
Cyclic AMP
Female
Fibroblasts
Hair Follicle
Humans
Keratin-5
Mesoderm
Nuclear Proteins
Organ Culture Techniques
RNA, Messenger
Receptors, Thyrotropin
Scalp
Skin
Thyroglobulin
Thyrotropin
Transcription Factors
Megjelenés:The Journal of Investigative Dermatology. - 129 : 5 (2009), p. 1126-1139. -
További szerzők:Kromminga, Arno Bíró Tamás (1968-) (élettanász) Borbíró István (1982-) (biokémikus, molekuláris biológus) Gáspár Erzsébet Zmijewski, Michal A. van Beek, Nina Langbein, Lutz Slominski, Andrzej T. Paus, Ralf
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5.

001-es BibID:BIBFORM001012
Első szerző:Bodó Enikő
Cím:Dissecting the impact of chemotherapy on the human hair follicle : a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy / Bodó E., Tobin D. J., Kamenisch Y., Bíró T., Berneburg M., Funk W., Paus R.
Dátum:2007
ISSN:0002-9440 (Print)
Megjegyzések:Chemotherapy-induced alopecia represents one of the major unresolved problems of clinical oncology. The underlying molecular pathogenesis in humans is virtually unknown because of the lack of adequate research models. Therefore, we have explored whether microdissected, organ-cultured, human scalp hair follicles (HFs) in anagen VI can be exploited for dissecting and manipulating the impact of chemotherapy on human HFs. Here, we show that these organ-cultured HFs respond to a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC), in a manner that resembles chemotherapy-induced HF dystrophy as it occurs in vivo: namely, 4-HC induced melanin clumping and melanin incontinence, down-regulated keratinocyte proliferation, massively up-regulated apoptosis of hair matrix keratinocytes, prematurely induced catagen, and up-regulated p53. In addition, 4-HC induced DNA oxidation and the mitochondrial DNA common deletion. The organ culture system facilitated the identification of new molecular targets for chemotherapy-induced HF damage by microarray technology (eg, interleukin-8, fibroblast growth factor-18, and glypican 6). It was also used to explore candidate chemotherapy protectants, for which we used the cytoprotective cytokine keratinocyte growth factor as exemplary pilot agent. Thus, this novel system serves as a powerful yet pragmatic tool for dissecting and manipulating the impact of chemotherapy on the human HF.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The American Journal of Pathology. - 171 : 4 (2007), p. 1153-1167. -
További szerzők:Tobin, Desmund J. Kamenisch, York Berneburg, Mark Funk, Wolfgang Paus, Ralf Bíró Tamás (1968-) (élettanász)
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6.

001-es BibID:bibEBI15718
Első szerző:Bodó Enikő
Cím:Vanilloid receptor-1 (VR-1) is widely expressed on various epithelial and mesenchymal cell types of human skin / Bodó, E., Kovács, I., Telek, A., Varga, A., Paus, R., Kovács, L., Bíró, T.
Dátum:2004
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
Megjelenés:Journal of Investigative Dermatology. - 123 : 2 (2004), p. 410-413. -
További szerzők:Kovács Ilona (1965-) (patológus) Telek Andrea (1977-) (élettanász) Varga Attila (1949-) (urológus, andrológus) Paus, Ralf Kovács László Bíró Tamás (1968-) (élettanász)
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7.

001-es BibID:BIBFORM039248
Első szerző:Conrad, Franziska
Cím:Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding / Conrad Franziska, Ohnemus Ulrich, Bodo Eniko, Biro Tamas, Tychsen Birte, Gerstmayer Bernhard, Bosio Andreas, Schmidt-Rose Thomas, Altgilbers Silke, Bettermann Albrecht, Saathoff Matthias, Meyer Wilfried, Paus Ralf
Dátum:2005
ISSN:1087-0024
Megjegyzések:In this study, it was investigated how estrogens (17-beta-estradiol, E2) affect the estrogen receptor (ER) expression and gene regulation of male versus female human scalp hair follicles in vitro. Anagen VI follicles from frontotemporal scalp skin were microdissected and organ-cultured for up to 9 d in the presence of E2 (1-100 nm). Immunohistochemistry was performed for ERbeta-expression, known to be predominant in human scalp hair follicles, and for TGF-beta2-expression (as negative key hair growth modulator), and E2-responsive genes in organ-cultured human scalp hair follicles (48 h, 10 nM) were explored by cDNA microarray, using a commercial skin focus chip (Memorec, Cologne, Germany). The distribution pattern of ERbeta and TGF-beta2-immunoreactivity differed between male and female hair follicles after 48 h culture. Of 1300 genes tested, several genes were regulated sex-dependent differently. The study reveals substantial sex-dependent differences in the response of frontotemporal human scalp hair follicles to E2. Recognition and systematic dissection of the E2-dependent gene regulation will be crucial for the development of more effective, gender-tailored management strategies for female versus male pattern balding.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Investigative Dermatology Symposium Proceedings. - 10 : 3 (2005), p. 243-246. -
További szerzők:Ohnemus, Ulrich Bodó Enikő Bíró Tamás (1968-) (élettanász) Tychsen, Birte Gerstmayer, Bernhard Bosio, Andreas Schmidt-Rose, Thomas Altgilbers, Silke Bettermann, Albrecht Saathoff, Matthias Meyer, Wilfried Paus, Ralf
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8.

001-es BibID:BIBFORM039252
Első szerző:Gáspár Erzsébet
Cím:Thyrotropin-Releasing Hormone Selectively Stimulates Human Hair Follicle Pigmentation / Gáspár, Erzsébet, Nguyen-Thi, Kim T, Hardenbicker Celine, Tiede Stephan, Plate Christian, Bodó Enikő, Knuever Jana, Funk Wolfgang, Bíró Tamás, Paus Ralf
Dátum:2011
ISSN:0022-202X
Megjegyzések:In amphibians, thyrotropin-releasing hormone (TRH) stimulates skin melanophores by inducing secretion of α-melanocyte-stimulating hormone in the pituitary gland. However, it is unknown whether this tripeptide neurohormone exerts any direct effects on pigment cells, namely, on human melanocytes, under physiological conditions. Therefore, we have investigated whether TRH stimulates pigment production in organ-cultured human hair follicles (HFs), the epithelium of which expresses both TRH and its receptor, and/or in full-thickness human skin in situ. TRH stimulated melanin synthesis, tyrosinase transcription and activity, melanosome formation, melanocyte dendricity, gp100 immunoreactivity, and microphthalmia-associated transcription factor expression in human HFs in a pituitary gland-independent manner. TRH also stimulated proliferation, gp100 expression, tyrosinase activity, and dendricity of isolated human HF melanocytes. However, intraepidermal melanogenesis was unaffected. As TRH upregulated the intrafollicular production of "pituitary" neurohormones (proopiomelanocortin transcription and ACTH immunoreactivity) and as agouti-signaling protein counteracted TRH-induced HF pigmentation, these pigmentary TRH effects may be mediated in part by locally generated melanocortins and/or by MC-1 signaling. Our study introduces TRH as a novel, potent, selective, and evolutionarily highly conserved neuroendocrine factor controlling human pigmentation in situ. This physiologically relevant and melanocyte sub-population-specific neuroendocrine control of human pigmentation deserves clinical exploration, e.g., for preventing or reversing hair graying.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Investigative Dermatology. - 131 : 12 (2011), p. 2368-2377. -
További szerzők:Nguyen-Thi, Kim T Hardenbicker, Celine Tiede, Stephan Plate, Christian Bodó Enikő Knüver, Jana Funk, Wolfgang Bíró Tamás (1968-) (élettanász) Paus, Ralf
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9.

001-es BibID:BIBFORM009198
Első szerző:Havlickova, Blanka
Cím:A human folliculoid microsphere assay for exploring epithelial- mesenchymal interactions in the human hair follicle / Havlickova, B., Biro, T., Mescalchin, A., Tschirschmann, M., Mollenkopf, H., Bettermann, A., Pertile, P., Lauster, R., Bodo, E., Paus, R.
Dátum:2009
ISSN:1523-1747 (Electronic)
Megjegyzések:The search for more effective drugs for the management of common hair growth disorders remains a top priority, both for clinical dermatology and industry. In this pilot study, we report a pragmatic organotypic assay for basic and applied hair research. The patented technique produces microdroplets, which generate human folliculoid microspheres (HFMs), consisting of human dermal papilla fibroblasts and outer root sheath keratinocytes within an extracellular matrix that simulates elements of the hair follicle mesenchyme. Studying a number of different markers (for example, proliferation, apoptosis, cytokeratin-6, versican), we show that these HFMs, cultured under well-defined conditions, retain several essential epithelial-mesenchymal interactions characteristic for human scalp hair follicle. Selected, recognized hair growth-modulatory agents modulate these parameters in a manner that suggests that HFMs allow the standardized preclinical assessment of test agents on relevant human hair growth markers under substantially simplified in vitro conditions that approximate the in vivo situation. Furthermore, we show by immunohistochemistry, reverse transcriptase-PCR, and DNA microarray techniques that HFMs also offer a useful discovery tool for the identification of target genes and their products for candidate hair drugs. HFM thus represent an instructive modern experimental and screening tool for basic and applied hair research in the human system.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Apoptosis
Cell Communication
Cell Proliferation
Cells, Cultured
Cyclosporine
Cytokines
Epithelial Cells
Gene Expression Profiling
Hair Follicle
Hepatocyte Growth Factor
Humans
Mesoderm
Microspheres
Megjelenés:The Journal of Investigative Dermatology. - 129 : 4 (2009), p. 972-983. -
További szerzők:Bíró Tamás (1968-) (élettanász) Mescalchin, Alessandra Tschirschmann, Miriam Mollenkopf, Hans Bettermann, Albrecht Pertile, Paolo Lauster, Roland Bodó Enikő Paus, Ralf
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10.

001-es BibID:BIBFORM055570
Első szerző:Kloepper, Jennifer E.
Cím:NF-kB Activity Is Required for Anagen Maintenance in Human Hair Follicles In Vitro / Jennifer E. Kloepper, Nancy Ernst, Karsten Krieger, Enikő Bodó, Tamás Bíró, Iain S. Haslam, Ruth Schmidt-Ullrich, Ralf Paus
Dátum:2014
ISSN:0022-202X
Tárgyszavak:Orvostudományok Elméleti orvostudományok szerkesztői levél
Megjelenés:Journal of Investigative Dermatology. - 134 : 7 (2014), p. 2036-2038. -
További szerzők:Ernst, Nancy Krieger, Karsten Bodó Enikő Bíró Tamás (1968-) (élettanász) Haslam, Iain S. Schmidt-Ullrich, Ruth Paus, Ralf
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11.

001-es BibID:BIBFORM001013
Első szerző:Peters, Eva M.J.
Cím:Probing the effects of stress mediators on the human hair follicle / Peters E.M.J., Liotiri S., Bodó E., Hagen E., Bíró T., Arck P.C., Paus R.
Dátum:2007
Megjegyzések:Stress alters murine hair growth, depending on substance P-mediated neurogenic inflammation and nerve growth factor (NGF), a key modulator of hair growth termination (catagen induction). Whether this is of any relevance in human hair follicles (HFs) is completely unclear. Therefore, we have investigated the effects of substance P, the central cutaneous prototypic stress-associated neuropeptide, on normal, growing human scalp HFs in organ culture. We show that these prominently expressed substance P receptor (NK1) at the gene and protein level. Organ-cultured HFs responded to substance P by premature catagen development, down-regulation of NK1, and up-regulation of neutral endopeptidase (degrades substance P). This was accompanied by mast cell degranulation in the HF connective tissue sheath, indicating neurogenic inflammation. Substance P down-regulated immunoreactivity for the growth-promoting NGF receptor (TrkA), whereas it up-regulated NGF and its apoptosis- and catagen-promoting receptor (p75NTR). In addition, MHC class I and beta2-microglobulin immunoreactivity were up-regulated and detected ectopically, indicating collapse of the HF immune privilege. In conclusion, we present a simplistic, but instructive, organ culture assay to demonstrate sensitivity of the human HF to key skin stress mediators. The data obtained therewith allow one to sketch the first evidence-based biological explanation for how stress may trigger or aggravate telogen effluvium and alopecia areata.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The American Journal of Pathology. - 171 : 6 (2007), p. 1872-1886. -
További szerzők:Liotiri, Sofia Bodó Enikő Hagen, Evelin Arck, Petra C. Paus, Ralf Bíró Tamás (1968-) (élettanász)
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12.

001-es BibID:BIBFORM016018
Első szerző:Poeggeler, Burkhard
Cím:Thyrotropin powers human mitochondria / Poeggeler, B., Knuever, J., Gaspar, E., Biro, T., Klinger, M., Bodo, E., Wiesner, R. J., Wenzel, B. E., Paus, R.
Dátum:2010
ISSN:0892-6638
Megjegyzések:Here we demonstrate that the neuropeptide hormone thyrotropin (TSH), which controls thyroid hormone production, exerts a major nonclassical function in mitochondrial biology. Based on transcriptional, ultrastructural, immunohistochemical, and biochemical evidence, TSH up-regulates mitochondrial biogenesis and consequently activity in organ-cultured normal human epidermis in situ. Mitochondrial activity was assessed by measuring 2 key components of the respiratory chain. The abundance of mitochondria was assessed employing 2 independent morphological techniques: counting their numbers in human epidermis by high-magnification light microscopy of skin sections immunostained for mitochondria-selective cytochromec-oxidase subunit 1 (MTCO1) and transmission electron microscopy (TEM). Treatment with 10 mU/ml of TSH for 6 d strongly up-regulates the number of light-microscopically visualized, MTCO1-demarcated mitochondria. On the ultrastructural level, TEM confirms that TSH indeed stimulates mitochondrial proliferation and biogenesis in the perinuclear region of human skin epidermal keratinocytes. On the transcriptional level, TSH up-regulates MTCO1 mRNA (quantitative RT-PCR) and significantly enhances complex I and IV (cytochrome-c-oxidase) activity. This study pioneers the concept that mitochondrial energy metabolism and biogenesis in a normal, prototypic human epithelial tissue underlies potent neuroendocrine controls and introduces human skin organ culture as a clinically relevant tool for further exploring this novel research frontier in the control of mitochondrial biology.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The FASEB Journal. - 24 : 5 (2010), p. 1525-1531. -
További szerzők:Knüver, Jana Gáspár Erzsébet Bíró Tamás (1968-) (élettanász) Klinger, Matthias Bodó Enikő Wiesner, Rudolf J. Wenzel, Björn E. Paus, Ralf
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