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1.

001-es BibID:BIBFORM048834
035-os BibID:PMID:24005054
Első szerző:Al-Nuaimi, Yusur
Cím:A meeting of two chronobiological systems : circadian proteins period1 and BMAL1 modulate the human hair cycle clock / Yusur Al-Nuaimi, Jonathan A. Hardman, Tamás Bíró, Iain S. Haslam, Michael P. Philpott, Balázs I. Tóth, Nilofer Farjo, Bessam Farjo, Gerold Baier, Rachel E. B. Watson, Benedetto Grimaldi, Jennifer E. Kloepper, Ralf Paus
Dátum:2014
ISSN:0022-202X
Megjegyzések:The hair follicle (HF) is a continuously remodeled mini organ that cycles between growth (anagen), regression (catagen), and relative quiescence (telogen). As the anagen-to-catagen transformation of microdissected human scalp HFs can be observed in organ culture, it permits the study of the unknown controls of autonomous, rhythmic tissue remodeling of the HF, which intersects developmental, chronobiological, and growth-regulatory mechanisms. The hypothesis that the peripheral clock system is involved in hair cycle control, i.e., the anagen-to-catagen transformation, was tested. Here we show that in the absence of central clock influences, isolated, organ-cultured human HFs show circadian changes in the gene and protein expression of core clock genes (CLOCK, BMAL1, and Period1) and clock-controlled genes (c-Myc, NR1D1, and CDKN1A), with Period1 expression being hair cycle dependent. Knockdown of either BMAL1 or Period1 in human anagen HFs significantly prolonged anagen. This provides evidence that peripheral core clock genes modulate human HF cycling and are an integral component of the human hair cycle clock. Specifically, our study identifies BMAL1 and Period1 as potential therapeutic targets for modulating human hair growth.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Calcium (Ca2+) signalling
Ion channel
Membrane transport
Molecular mechanisms of disease
Skin
TRP channels
Megjelenés:Journal of Investigative Dermatology 134 : 3 (2014), p. 610-619. -
További szerzők:Hardman, Jonathan A. Bíró Tamás (1968-) (élettanász) Haslam, Iain S. Philpott, Michael P. Tóth István Balázs (1978-) (élettanász) Farjo, Nilofer Farjo, Bessam Baier, Gerold Watson, Rachel E. B. Grimaldi, Benedetto Kloepper, Jennifer E. Paus, Ralf
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2.

001-es BibID:BIBFORM084530
035-os BibID:(WoS)000383620000028 (Scopus)84987814942
Első szerző:Bertolini, Marta
Cím:Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse / Bertolini M., Pretzlaff M., Sulk M., Bähr M., Gherardini J., Uchida Y., Reibelt M., Kinori M., Rossi A., Bíró T., Paus R.
Dátum:2016
ISSN:0007-0963 1365-2133
Megjegyzések:Background Alopecia areata (AA) is an autoimmune disorder whose pathogenesisinvolves the collapse of the relati ve immune privilege (IP) of the hair follicle(HF). Given that vasoactive intestinal peptide (VIP) is an immunoinhibitory neu-ropeptide released by perifollicular sensory nerve ?bres, which play a role in IPmaintenance, it may modulate human HF-IP and thus be therapeutically relevantfor AA.Objectives To answer the following questions: Do human HFs express VIP recep-tors, and does their stimulation protect from or restore experimentally inducedHF-IP collapse? Is VIP signalling defective in AA HFs?Methods Firstly, VIP and VIP receptor (VPAC1, VPAC2) expression in human scalpHFs and AA skin was assessed. In HF organ culture, we then explored whetherVIP treatment can restore and/or protect from interferon-c-induced HF-IP col-lapse, assessing the expression of the key IP markers by quantitative (immuno-)histomorphometry.Results Here we provide the ?rst evidence that VIP receptors are expressed in theepithelium of healthy human HFs at the gene and protein level. Furthermore,VIP receptor protein expression, but not VIP+nerve ?bres, is signi?cantly down-regulated in lesional hair bulbs of patients with AA, suggesting defects in VIPreceptor-mediated signalling. Moreover, we show that VIP protects the HF fromexperimentally induced IP collapse in vitro, but does not fully restore it once col-lapsed.Conclusions These pilot data suggest that insuf?cient VIP receptor-mediated sig-nalling may contribute to impairing HF-IP in patients with AA, and that VIP is apromising candidate ♭HF-IP guardian' that may be therapeutically exploited toinhibit the progression of AA lesions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:British Journal Of Dermatology. - 175 : 3 (2016), p. 531-541. -
További szerzők:Pretzlaff, M. Sulk, M. Bähr, M. Gherardini, Jennifer Uchida, Yohei Reibelt, M. Kinori, M. Rossi, A. Bíró Tamás (1968-) (élettanász) Paus, Ralf
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3.

001-es BibID:BIBFORM042119
Első szerző:Bíró Tamás (élettanász)
Cím:TRP Channels in Cutaneous Biology in Health and Disease / Biro Tamas, Paus, Ralf
Dátum:2011
Megjegyzések:Recent research progress has revealed that numerous transient receptor potential (TRP) channels are not only expressed on sensory afferent endings in human and murine skin, but, intriguingly, also on various non-neuronal skin cell populations such as mast cells, keratinocytes, and sebocytes. These TRP channels have now become implicated in an increasing variety of cutaneous functions. In this chapter, we focus on delineating the physiological regulatory function of TRP channels in skin-derived pruritus (pruritoceptive itch) and in the control of proliferation, differentiation, apoptosis, and cytokine/mediator production of various cell types of the skin and its appendages (e.g. hair follicle, sebaceous gland). Moreover, we discuss the emerging evidence that selected TRP channels are also involved in skin diseases, such as e.g. in skin carcinogenesis and skin tumor growth, acne, seborrhea, psoriasis, and hair growth disorders. We close by delineating some important future basic and clinical research directions and strategies that are geared towards the therapeutic targeting of defined TRP channels for the management of skin disorders.
ISBN:978 1 61668 337 5
Tárgyszavak:Orvostudományok Elméleti orvostudományok könyvfejezet
TRP channels
Cutaneous Biology
Megjelenés:TRP Channels in Health and Disease : Implications for Diagnosis and Therapy / ed. Arpad Szallasi. - p. 331-361. -
További szerzők:Paus, Ralf
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4.

001-es BibID:BIBFORM039266
Első szerző:Bíró Tamás (élettanász)
Cím:Characterization of functional vanilloid receptors expressed by mast cells / Biro, T., Maurer, M., Modarres, S., Lewin, N. E., Brodie, C., Acs, G., Acs, P., Paus, R., Blumberg, P. M.
Dátum:1998
ISSN:0006-4971
Megjegyzések:Capsaicin and its ultrapotent analog resiniferatoxin (RTX) act through specific vanilloid receptors on sensory neurons. The C-type receptor is coupled to Ca-45 uptake, whereas the R-type is detectable by [H-3]RTX binding. We describe here specific vanilloid responses in murine mast cells (MCs). In the MC lines and in bone marrow-derived mast cells. capsaicin and RTX induced Ca-45 uptake similarly to that observed for cultured rat dorsal root ganglion neurons (DRGs). This response was antagonized by the antagonists capsazepine and ruthenium red. As in DRGs, pretreatment of MCs with capsaicin or RTX induced desensitization to subsequent stimulation of Ca-45 uptake. The potency for desensitization by RTX in the MCs corresponded to that for Ca-45 uptake, whereas in DRGs it occurred at significantly lower concentrations corresponding to that for the high-affinity [H-3]RTX binding site. Consistent with this difference, in MCs we were unable to detect [H-3]RTX binding. Vanilloids were noncytotoxic to the MCs, in contrast to the DRGs. Although vanilloids did not cause degranulation in MCs, in the P815 clone capsaicin evoked selective interleukin-4 release. We conclude that certain MCs possess vanilloid receptors, but only the C-type that functions as a channel. Our finding that MCs can respond directly to capsaicin necessitates a reevaluation of the in vivo pathway of inflammation in response to vanilloids. This is a US government work. There are no restrictions on its use.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Blood. - 91 : 4 (1998), p. 1332-1340. -
További szerzők:Maurer, Marcus Modarres, Shayan Lewin, Nancy E. Brodie, Chaya Ács Géza (1939-) (traumatológus) Ács Péter Paus, Ralf Blumberg, Peter M.
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5.

001-es BibID:BIBFORM020120
Első szerző:Bíró Tamás (élettanász)
Cím:Hair cycle control by vanilloid receptor-1 (TRPV1) : evidence from TRPV1 knockout mice / Tamás Bíró, Enikő Bodó, Andrea Telek, Tamás Géczy, Birte Tychsen, László Kovács, Ralf Paus
Dátum:2006
ISSN:0022-202X
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Investigative Dermatology. - 126 : 8 (2006), p. 1909-1912. -
További szerzők:Bodó Enikő Telek Andrea (1977-) (élettanász) Géczy Tamás (1980-) (élettanász) Tychsen, Birte Kovács László Paus, Ralf
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6.

001-es BibID:BIBFORM011461
Első szerző:Bíró Tamás (élettanász)
Cím:The endocannabinoid system of the skin in health and disease : novel perspectives and therapeutic opportunities / Bíró T., Tóth B. I., Haskó G., Paus R., Pacher P.
Dátum:2009
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Trends in Pharmacological Sciences. - 30 : 8 (2009), p. 411-420. -
További szerzők:Tóth István Balázs (1978-) (élettanász) Haskó György (1967-) (biokémikus) Paus, Ralf Pacher Pál
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DOI
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7.

001-es BibID:BIBFORM001015
Első szerző:Bíró Tamás (élettanász)
Cím:TRP channels as novel players in the pathogenesis and therapy of itch / Tamás Bíró, Balázs I. Tóth, Rita Marincsák, Nóra Dobrosi, Tamás Géczy, Ralf Paus
Dátum:2007
ISSN:0925-4439
Megjegyzések:Itch (pruritus) is a sensory phenomenon characterized by a (usually) negative affective component and the initiation of a special behavioral act, i.e. scratching. Older studies predominantly have interpreted itch as a type of pain. Recent neurophysiological findings, however, have provided compelling evidence that itch (although it indeed has intimate connections to pain) rather needs to be understood as a separate sensory modality. Therefore, a novel pruriceptive system has been proposed, within which itch-inducing peripheral mediators (pruritogens), itch-selective receptors (pruriceptors), sensory afferents and spinal cord neurons, and defined, itch-processing central nervous system regions display complex, layered responses to itch. In this review, we begin with a current overview on the neurophysiology of pruritus, and distinguish it from that of pain. We then focus on the functional characteristics of the large family of transient receptor potential (TRP) channels in skin-coupled sensory mechanisms, including itch and pain. In particular, we argue that - due to their expression patterns, activation mechanisms, regulatory roles, and pharmacological sensitivities - certain thermosensitive TRP channels are key players in pruritus pathogenesis. We close by proposing a novel, TRP-centered concept of pruritus pathogenesis and sketch important future experimental directions towards the therapeutic targeting of TRP channels in the clinical management of itch.
Tárgyszavak:Orvostudományok Elméleti orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
TRP channels
pruritogens
pruriceptive
itch
Megjelenés:Biochimica et Biophysica Acta (BBA). Molecular Basis of Disease. - 1772 : 8 (2007), p. 1004-1021. -
További szerzők:Tóth István Balázs (1978-) (élettanász) Marincsák Rita (1979-) (fogszakorvos) Dobrosi Nóra (1981-) (molekuláris biológus) Géczy Tamás (1980-) (élettanász) Paus, Ralf
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8.

001-es BibID:BIBFORM016014
Első szerző:Bodó Enikő
Cím:Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones / Bodo, E., Kany, B., Gaspar, E., Knuver, J., Kromminga, A., Ramot, Y., Biro, T., Tiede, S., van Beek, N., Poeggeler, B., Meyer, K. C., Wenzel, B. E., Paus, R.
Dátum:2010
ISSN:0013-7227
Megjegyzések:Several elements of the hypothalamic-pituitary-thyroid axis (HPT) reportedly are transcribed by human skin cell populations, and human hair follicles express functional receptors for TSH. Therefore, we asked whether the epidermis of normal human skin is yet another extrathyroidal target of TSH and whether epidermis even produces TSH. If so, we wanted to clarify whether intraepidermal TSH expression is regulated by TRH and/or thyroid hormones and whether TSH alters selected functions of normal human epidermis in situ. TSH and TSH receptor (TSH-R) expression were analyzed in the epidermis of normal human scalp skin by immunohistochemistry and PCR. In addition, full-thickness scalp skin was organ cultured and treated with TSH, TRH, or thyroid hormones, and the effect of TSH treatment on the expression of selected genes was measured by quantitative PCR and/or quantitative immunohistochemistry. Here we show that normal human epidermis expresses TSH at the mRNA and protein levels in situ and transcribes TSH-R. It also contains thyrostimulin transcripts. Intraepidermal TSH immunoreactivity is up-regulated by TRH and down-regulated by thyroid hormones. Although TSH-R immunoreactivity in situ could not be documented within the epidermis, but in the immediately adjacent dermis, TSH treatment of organ-cultured human skin strongly up-regulated epidermal expression of involucrin, loricrin, and keratins 5 and 14. Thus, normal human epidermis in situ is both an extrapituitary source and (possibly an indirect) target of TSH signaling, which regulates defined epidermal parameters. Intraepidermal TSH expression appears to be regulated by the classical endocrine controls that determine the systemic HPT axis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrinology. - 151 : 4 (2010), p. 1633-1642. -
További szerzők:Kany Benedikt Gáspár Erzsébet Knüver, Jana Kromminga, Arno Ramot, Yuval Bíró Tamás (1968-) (élettanász) Tiede, Stephan van Beek, Nina Poeggeler, Burkhard Meyer, Katja C. Wenzel, Björn E. Paus, Ralf
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9.

001-es BibID:BIBFORM014374
Első szerző:Bodó Enikő
Cím:A Hot New Twist to Hair Biology : involvement of Vanilloid Receptor-1 (VR1/TRPV1) Signaling in Human Hair Growth Control / Enikő Bodó, Tamás Bíró, Andrea Telek, Gabriella Czifra, Zoltán Griger, Balázs I. Tóth, Alessandra Mescalchin, Taisuke Ito, Albrecht Bettermann, László Kovács, Ralf Paus
Dátum:2005
ISSN:0002-9440
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Pathology 166 : 4 (2005), p. 985-998. -
További szerzők:Bíró Tamás (1968-) (élettanász) Telek Andrea (1977-) (élettanász) Czifra Gabriella (1975-) (élettanász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Tóth István Balázs (1978-) (élettanász) Mescalchin, Alessandra Ito, Taisuke Bettermann, Albrecht Kovács László (1939-) (élettanász) Paus, Ralf
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10.

001-es BibID:BIBFORM009197
Első szerző:Bodó Enikő
Cím:Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone / Bodo, E., Kromminga, A., Biro, T., Borbiro, I., Gaspar, E., Zmijewski, M. A., van Beek, N., Langbein, L., Slominski, A. T., Paus, R.
Dátum:2009
ISSN:1523-1747 (Electronic)
Megjegyzések:Pituitary thyroid-stimulating hormone (TSH) regulates thyroid hormone synthesis via receptors (TSH-R) expressed on thyroid epithelial cells. As the hair follicle (HF) is uniquely hormone-sensitive and, hypothyroidism with its associated, increased TSH serum levels clinically can lead to hair loss, we asked whether human HFs are a direct target for TSH. Here, we report that normal human scalp skin and microdissected human HFs express TSH-R mRNA. TSH-R-like immunoreactivity is limited to the mesenchymal skin compartments in situ. TSH may alter HF mesenchymal functions, as it upregulates alpha-smooth muscle actin expression in HF fibroblasts. TSH-R stimulation by its natural ligand in organ culture changes the expression of several genes of human scalp HFs (for example keratin K5), upregulates the transcription of classical TSH target genes and enhances cAMP production. Although the functional role of TSH in human HF biology awaits further dissection, these findings document that intracutaneous TSH-Rs are fully functional in situ and that HFs of female individuals are direct targets for nonclassical, extrathyroidal TSH bioregulation. This suggests that organ-cultured scalp HFs provide an instructive and physiologically relevant human model for exploring nonclassical functions of TSH, in and beyond the skin.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Actins
Cell Proliferation
Cells, Cultured
Cyclic AMP
Female
Fibroblasts
Hair Follicle
Humans
Keratin-5
Mesoderm
Nuclear Proteins
Organ Culture Techniques
RNA, Messenger
Receptors, Thyrotropin
Scalp
Skin
Thyroglobulin
Thyrotropin
Transcription Factors
Megjelenés:The Journal of Investigative Dermatology. - 129 : 5 (2009), p. 1126-1139. -
További szerzők:Kromminga, Arno Bíró Tamás (1968-) (élettanász) Borbíró István (1982-) (biokémikus, molekuláris biológus) Gáspár Erzsébet Zmijewski, Michal A. van Beek, Nina Langbein, Lutz Slominski, Andrzej T. Paus, Ralf
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elektronikus változat
elektronikus változat
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11.

001-es BibID:BIBFORM001012
Első szerző:Bodó Enikő
Cím:Dissecting the impact of chemotherapy on the human hair follicle : a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy / Bodó E., Tobin D. J., Kamenisch Y., Bíró T., Berneburg M., Funk W., Paus R.
Dátum:2007
ISSN:0002-9440 (Print)
Megjegyzések:Chemotherapy-induced alopecia represents one of the major unresolved problems of clinical oncology. The underlying molecular pathogenesis in humans is virtually unknown because of the lack of adequate research models. Therefore, we have explored whether microdissected, organ-cultured, human scalp hair follicles (HFs) in anagen VI can be exploited for dissecting and manipulating the impact of chemotherapy on human HFs. Here, we show that these organ-cultured HFs respond to a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC), in a manner that resembles chemotherapy-induced HF dystrophy as it occurs in vivo: namely, 4-HC induced melanin clumping and melanin incontinence, down-regulated keratinocyte proliferation, massively up-regulated apoptosis of hair matrix keratinocytes, prematurely induced catagen, and up-regulated p53. In addition, 4-HC induced DNA oxidation and the mitochondrial DNA common deletion. The organ culture system facilitated the identification of new molecular targets for chemotherapy-induced HF damage by microarray technology (eg, interleukin-8, fibroblast growth factor-18, and glypican 6). It was also used to explore candidate chemotherapy protectants, for which we used the cytoprotective cytokine keratinocyte growth factor as exemplary pilot agent. Thus, this novel system serves as a powerful yet pragmatic tool for dissecting and manipulating the impact of chemotherapy on the human HF.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The American Journal of Pathology. - 171 : 4 (2007), p. 1153-1167. -
További szerzők:Tobin, Desmund J. Kamenisch, York Berneburg, Mark Funk, Wolfgang Paus, Ralf Bíró Tamás (1968-) (élettanász)
Internet cím:elektronikus változat
elektronikus változat
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12.

001-es BibID:bibEBI15718
Első szerző:Bodó Enikő
Cím:Vanilloid receptor-1 (VR-1) is widely expressed on various epithelial and mesenchymal cell types of human skin / Bodó, E., Kovács, I., Telek, A., Varga, A., Paus, R., Kovács, L., Bíró, T.
Dátum:2004
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
Megjelenés:Journal of Investigative Dermatology. - 123 : 2 (2004), p. 410-413. -
További szerzők:Kovács Ilona (1965-) (patológus) Telek Andrea (1977-) (élettanász) Varga Attila (1949-) (urológus, andrológus) Paus, Ralf Kovács László Bíró Tamás (1968-) (élettanász)
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