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001-es BibID:BIBFORM049402
Első szerző:Jóna István (élettanász, fizikus)
Cím:Effect of charybdotoxin and iberiotoxin on the ryanodine receptor - calcium channel / Istvan Jona, Janos Almassy
Dátum:2009
Megjegyzések:Action potential of the skeletal muscle surface membrane leads to Ca2+ release from the sarcoplasmic reticulum via direct coupling between dihydropyridine (DHP)- and Ca2+ release channels (RyR). The structural basis of the allosteric connection is the intracellular loop between the 2nd and 3rd transmembrane repeat of the DHPR ?1 subunit. We previously showed that a ?-scorpion toxin maurocalcine (MCa) that shares primary sequence homology with the amino acid residues of DHPR-loop peptide essential for RyR activation raises single RyR channel open probability and blocks RyR in long lasting subconductive states The aim of the present study was to confirm the hypothesis that MCa shares common binding sites with the DHPR loop peptide on RyR, and to characterize the potential effects of other MCa-homologue toxins (such as charybdotoxin (ChTx) and iberiotoxin (IbTx)) on RyR gating. Using single channel electrophysiology we demonstrated a competitive interaction between the loop peptide ? Mca and MCa ? ChTx respectively. We also found that ChTx albeit increased RyR open probability, induced long channel closures in dose-, and membrane potential- and Ca2+-dependent manner, but not in a use dependent fashion, while IbTx in spite of the significant homology was ineffective.
Tárgyszavak:Természettudományok Biológiai tudományok idézhető absztrakt
calcium release
Megjelenés:Journal of Physiological Sciences. - 9 : Suppl. 1 (2009), p. 252. -
További szerzők:Almássy János (1981-) (élettanász, biológus, angol-magyar szakfordító)
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