CCL

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001-es BibID:BIBFORM037815
Első szerző:Kőszeghy Áron (Ph.D hallgató, élettanász)
Cím:Purkinje-like cells of the rat cochlear nucleus : a combined functional and morphological study / Kőszeghy, Á., Pál, B., Pap, P., Pocsai, K., Nagy, Zs., Szücs, G., Rusznák, Z.
Dátum:2009
ISSN:0006-8993
Megjegyzések:Purkinje-like cells (PLCs) of the cochlear nucleus (CN) are strongly calbindin positive neurones with unknown function. In the present work functional and morphological methods have been employed to provide data about PLCs in general, and about their possible involvement in the synaptic organisation of the CN in particular. PLCs had slightly elongated soma, from which a complex dendritic arborisation extended with highly variable dimensions. On the basis of their morphology, three classes of PLCs were identified. Positively identified PLCs fired a train of action potentials on sustained depolarization. When hyperpolarizing stimuli were applied, the presence of a slowly activating, ZD7288-sensitive inward current was noted that corresponded to the h-current. PLCs received both excitatory and inhibitory synaptic inputs. Functional experiments revealed that 76% and 14% of the spontaneous inhibitory postsynaptic currents recorded from the cell bodies of the PLCs were mediated via glycinergic and GABAergic synapses, respectively. PLCs presented strong cerebellin1-like immunoreactivity, but its distribution differed from that seen in cerebellar Purkinje cells. Our results indicate that PLCs are parts of the synaptic circuitry of the CN, thus they may be actively involved in the processing and analysis of auditory information.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research. - 1297 (2009), p. 57-69. -
További szerzők:Pál Balázs (1975-) (élettanász) Pap Pál (1981-) (élettanász) Pocsai Krisztina (1978-) (élettanász) Nagy Zsuzsanna (1986-) (élettanász) Szűcs Géza (1948-) (élettanász) Rusznák Zoltán (1965-) (élettanász)
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001-es BibID:BIBFORM009112
Első szerző:Pál Balázs (élettanász)
Cím:Targets, receptors and effects of muscarinic neuromodulation on giant neurones of the rat dorsal cochlear nucleus / Pal, B., Koszeghy, A., Pap, P., Bakondi, G., Pocsai, K., Szucs, G., Rusznak, Z.
Dátum:2009
ISSN:0953-816X
Megjegyzések:Although cholinergic modulation of the cochlear nucleus (CN) is functionally important, neither its cellular consequences nor the types of receptors conveying it are precisely known. The aim of this work was to characterise the cholinergic effects on giant cells of the CN, using electrophysiology and quantitative polymerase chain reaction. Application of the cholinergic agonist carbachol increased the spontaneous activity of the giant cells; which was partly the consequence of the reduction in a K(+) conductance. This effect was mediated via M4 and M3 receptors. Cholinergic modulation also affected the synaptic transmission targeting the giant cells. Excitatory synaptic currents evoked by the stimulation of the superficial and deep regions of the CN were sensitive to cholinergic modulation: the amplitude of the first postsynaptic current was reduced, and the short-term depression was also altered. These changes were mediated via M3 receptors alone and via the combination of M4, M2 and M3 receptors, when the superficial and deep layers, respectively, were activated. Inhibitory synaptic currents evoked from the superficial layer showed short-term depression, but they were unaffected by carbachol. In contrast, inhibitory currents triggered by the activation of the deep parts exhibited no significant short-term depression, but they were highly sensitive to cholinergic activation, which was mediated via M3 receptors. Our results indicate that pre- and postsynaptic muscarinic receptors mediate cholinergic modulation on giant cells. The present findings shed light on the cellular mechanisms of a tonic cholinergic modulation in the CN, which may become particularly important in evoking contralateral excitatory responses under certain pathological conditions
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
agonist
Carbachol
CN
Cochlear Nucleus
dorsal cochlear nucleus
Electrophysiology
giant
Health
neurone
physiology
Polymerase Chain Reaction
rat
receptor
Synaptic Transmission
Megjelenés:The European Journal of Neuroscience. - 30 : 5 (2009), p. 769-782. -
További szerzők:Kőszeghy Áron (1983-) (Ph.D hallgató, élettanász) Pap Pál (1981-) (élettanász) Bakondi Gábor (1980-) (élettanász) Pocsai Krisztina (1978-) (élettanász) Szűcs Géza (1948-) (élettanász) Rusznák Zoltán (1965-) (élettanász)
Internet cím:elektronikus változat
DOI
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