CCL

Összesen 5 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM078411
035-os BibID:(PMID)30734834 (WoS)000472512500009 (Scopus)85061242629
Első szerző:Baksa Brigitta (fogorvos)
Cím:Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus / Baksa B., Kovács A., Bayasgalan T., Szentesi P., Kőszeghy Á., Szücs P., Pál B.
Dátum:2019
ISSN:1420-682X
Megjegyzések:The pedunculopontine nucleus (PPN) is a part of the reticular activating system which is composed of cholinergic, glutamatergic and GABAergic neurons. Early electrophysiological studies characterized and grouped PPN neurons based on certain functional properties (i.e. the presence or absence of the A-current, spike latency, and low threshold spikes). Although other electrophysiological characteristics of these neurons were also described (as high threshold membrane potential oscillations, great differences in spontaneous firing rate and the presence or absence of the M-current), systematic assessment of these properties and correlation of them with morphological markers are still missing. In this work, we conducted electrophysiological experiments on brain slices of genetically identified cholinergic neurons in the PPN. Electrophysiological properties were compared with rostrocaudal location of the neuronal soma and selected morphometric features obtained with post hoc reconstruction. We found that functional subgroups had different proportions in the rostral and caudal subregions of the nucleus. Neurons with A-current can be divided to early-firing and late-firing neurons, where the latter type was found exclusively in the caudal subregion. Similar to this, different parameters of high threshold membrane potential oscillations also showed characteristic rostrocaudal distribution. Furthermore, based on our data we propose that high threshold oscillations rather emerge from neuronal somata and not from the proximal dendrites. In summary, we demonstrated the existence and spatial distribution of functional subgroups of genetically identified PPN cholinergic neurons, which are in accordance with differences found in projection and in vivo functional findings of the subregions. Being aware of functional differences of PPN subregions will help the design and analysis of experiments using genetically encoded opto- and chemogenetic markers for in vivo experiments.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
pedunculopontine nucleus
cholinergic neuron
spike delay
A-current
rostrocaudal gradient
high threshold oscillation
Megjelenés:Cellular And Molecular Life Sciences. - 76 : 14 (2019), p. 2799-2815. -
További szerzők:Kovács Adrienn (1989-) (molekuláris biológus) Bayasgalan, Tsogbadrakh (1983-) (Általános orvos) Szentesi Péter (1967-) (élettanász) Kőszeghy Áron (1983-) (Ph.D hallgató, élettanász) Szűcs Péter (1974-) (kutatóorvos) Pál Balázs (1975-) (élettanász)
Pályázati támogatás:KTIA_13_NAP-A-I/10
Egyéb
2017-1.2.1-NKP-2017-00002
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM082733
035-os BibID:(WoS)000494753900001 (Scopus)85075092426
Első szerző:Pál Balázs (élettanász)
Cím:Response to "Concerns regarding Baksa et al., Cell Molec. Life Sci., 2019." by Edgar Garcia-Rill and Francisco J. Urbano (CMLS-D-18-0156R1) / Balázs Pal
Dátum:2019
ISSN:1420-682X
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
folyóiratcikk
Megjelenés:Cellular And Molecular Life Sciences. - 76 : 23 (2019), p. 4583-4587. -
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM078412
035-os BibID:(PMID)29766217 (WoS)000437429000003 (Scopus)85046905592
Első szerző:Pál Balázs (élettanász)
Cím:Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability / Balázs Pál
Dátum:2018
ISSN:1420-682X
Megjegyzések:Glutamate is the most abundant neurotransmitter of the central nervous system, as the majority of neurons use glutamate as neurotransmitter. It is also well known that this neurotransmitter is not restricted to synaptic clefts, but found in the extrasynaptic regions as ambient glutamate. Extrasynaptic glutamate originates from spillover of synaptic release, as well as from astrocytes and microglia. Its concentration is magnitudes lower than in the synaptic cleft, but receptors responding to it have higher affinity for it. Extrasynaptic glutamate receptors can be found in neuronal somatodendritic location, on astroglia, oligodendrocytes or microglia. Activation of them leads to changes of neuronal excitability with different amplitude and kinetics. Extrasynaptic glutamate is taken up by neurons and astrocytes mostly via EAAT transporters, and astrocytes, in turn metabolize it to glutamine. Extrasynaptic glutamate is involved in several physiological phenomena of the central nervous system. It regulates neuronal excitability and synaptic strength by involving astroglia; contributing to learning and memory formation, neurosecretory and neuromodulatory mechanisms, as well as sleep homeostasis. The extrasynaptic glutamatergic system is affected in several brain pathologies related to excitotoxicity, neurodegeneration or neuroinflammation. Being present in dementias, neurodegenerative and neuropsychiatric diseases or tumor invasion in a seemingly uniform way, the system possibly provides a common component of their pathogenesis. Although parts of the system are extensively discussed by several recent reviews, in this review I attempt to summarize physiological actions of the extrasynaptic glutamate on neuronal excitability and provide a brief insight to its pathology for basic understanding of the topic.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
NMDA receptor
AMPA receptor
metabotropic glutamate receptor
astrocyte
synaptic spillover
excitotoxicity
Megjelenés:Cellular and Molecular Life Sciences. - 75 : 16 (2018), p. 2917-2949. -
Pályázati támogatás:KTIA_13_NAP-A-I/10
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM018461
Első szerző:Pál Balázs (élettanász)
Cím:HCN channels contribute to the intrinsic activity of cochlear pyramidal cells / Pal, B., Por, A., Szücs, G., Kovacs, I., Rusznak, Z.
Dátum:2003
ISSN:1420-682X
Megjegyzések:A hyperpolarization-activated current recorded from the pyramidal cells of the dorsal cochlear nucleus was investigated in the present study by using 150- to 200-microm-thick brain slices prepared from 6- to 14-day-old Wistar rats. The pyramidal neurones exhibited a slowly activating inward current on hyperpolarization. The reversal potential of this component was -32 +/- 3 mV (mean +/- SE, n = 6), while its half-activation voltage was -99 +/- 1 mV with a slope factor of 10.9 +/- 0.4 mV (n = 27). This current was highly sensitive to the extracellular application of both 1 mM Cs+ and 10 microM ZD7288. The electrophysiological properties and the pharmacological sensitivity of this current indicated that it corresponded to a hyperpolarization-activated non-specific cationic current (Ih). Our experiments showed that there was a correlation between the availability of the h-current and the spontaneous activity of the pyramidal cells, suggesting that this conductance acts as a pacemaker current in these neurones. Immunocytochemical experiments were also conducted on freshly isolated pyramidal cells to demonstrate the possible subunit composition of the channels responsible for the genesis of the pyramidal h-current. These investigations indicated the presence of HCN1, HCN2 and HCN4 subunits in the pyramidal cells.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cochlear nucleus
pyramidal cell
Ih
spontaneous activity
HCN subunits
Megjelenés:Cellular And Molecular Life Sciences. - 60 : 10 (2003), p. 2189-2199. -
További szerzők:Pór Ágnes Szűcs Géza (1948-) (élettanász) Kovács Ilona (1965-) (patológus) Rusznák Zoltán (1965-) (élettanász)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM018462
Első szerző:Rusznák Zoltán (élettanász)
Cím:Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum / Rusznak, Z., Pocsai, K., Kovacs, I., Por, A., Pal, B., Biro, T., Szücs, G.
Dátum:2004
ISSN:1420-682X
Megjegyzések:In this work, the distributions of some acidsensitivetwo-pore-domain K+ channels (TASK-1, TASK-2 and TASK-3) were investigated in the rat and human cerebellum. Astrocytes situated in rat cerebellar tissuesections were positive for TASK-2 channels. Purkinjecells were strongly stained and granule cells and astrocytes were moderately positive for TASK-3. Astrocytesisolated from the hippocampus, cerebellum and cochlearnucleus expressed TASK channels in a primary tissueculture. Our results suggest that TASK channel expressionmay be significant in the endoplasmic reticulum ofthe astrocytes. The human cerebellum showed weakTASK-2 immunolabelling. The pia mater, astrocytes,Purkinje and granule cells demonstrated strong TASK-1and TASK-3 positivities. The TASK-3 labelling wasstronger in general, but it was particularly intense in thePurkinje cells and pia mater.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
TASK immunopositivity
astrocyte culture
cerebellum
endoplasmic reticulum
human brain
Megjelenés:Cellular And Molecular Life Sciences. - 61 : 12 (2004), p. 1532-1542. -
További szerzők:Pocsai Krisztina (1978-) (élettanász) Kovács Ilona (1965-) (patológus) Pór Ágnes Pál Balázs (1975-) (élettanász) Bíró Tamás (1968-) (élettanász) Szűcs Géza (1948-) (élettanász)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.