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001-es BibID:BIBFORM018460
Első szerző:Price, Christopher J.
Cím:Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare / Price Christopher J., Karayannis Theofanis, Pál Balázs Zoltán, Capogna Marco
Dátum:2005
ISSN:0028-3908
Megjegyzések:We have studied the effects of groups II and III metabotropic glutamate receptor (mGluR) activation on excitatory responses recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare (SLM). Excitatory postsynaptic currents (EPSCs) evoked by stimulation of the perforant pathway were reduced either by the group II mGluR agonist LY354740 (50e100 nM,49.1G5.7% of control) or by the group III mGluR agonist L-2-amino-4-phosphonobutyric acid (L-AP4) (50 mM, 36.8G4.4% of control). Both drugs significantly enhanced paired-pulse facilitation of the EPSCs. Furthermore, both 100 nM LY354740 and 50 mM L-AP4 reduced the frequency, but not the amplitude, of miniature excitatory synaptic currents (mEPSCs), recorded in the presence of 1 mM TTX and 50 mM picrotoxin, or EPSCs evoked by perforant pathway stimulation in the presence of 2.5 mM Sr2C. The broad-spectrum mGluR antagonist LY341495 (10e50 mM) did not affect test EPSCs elicited 210 ms after stimulation at 100 Hz. At network level, 1e5 mM LY354740 significantly reduced the power of gamma frequency oscillations induced by 20 mM carbachol, 600 nM kainate and 5 mM KC in hippocampal CA1 area. Our results show powerful modulation of excitatory transmission impinging on interneurons of CA1 SLM by presynaptic group II or III mGluRs.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuropharmacology. - 49 : Suppl.1. (2005), p. 45-56. -
További szerzők:Karayannis, Theofanis Pál Balázs (1975-) (élettanász) Capogna, Marco
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