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001-es BibID:	BIBFORM095573
035-os BibID:	(cikkazonosító)109594 (WoS)000688508300032 (Scopus)85113379671 (PubMed)34433068
Első szerző:	Dautan, Daniel
Cím:	Modulation of motor behavior by the mesencephalic locomotor region / Daniel Dautan, Adrienn Kovács, Tsogbadrakh Bayasgalan, Miguel Diaz, Balazs Pal, Juan Mena-Segovia
Dátum:	2021
ISSN:	2211-1247
Megjegyzések:	The mesencephalic locomotor region (MLR) is a functionally-defined area located in the midbrain that serves as an interface between higher-order motor systems (e.g. basal ganglia and cortex) and lower motor neurons (brainstem and spinal cord). The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF) and their activation has been proposed to elicit different modalities of movement, but whether differences in connectivity and physiological properties explain their contributions to motor activity is not known. Here we report that CnF-glutamatergic neurons are functionally homogeneous and have short-range axonal projections, whereas PPN-glutamatergic neurons are heterogeneous and maintain long-range connections with other motor circuits, most notably the basal ganglia. Optogenetic activation of CnF-neurons produced short-lasting muscle activation and fast-onset, involuntary motor activity, whereas activation of PPN-neurons produced long-lasting muscle activation, decreased locomotion and disrupted gait. Our results thus reveal a differential contribution to motor behavior in the structures that compose the MLR.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Cell Reports. - 36 : 8 (2021), p. 109594. -
További szerzők:	Kovács Adrienn (1989-) (molekuláris biológus) Bayasgalan, Tsogbadrakh (1983-) (Általános orvos) Diaz-Acevedo, Miguel A. Pál Balázs (1975-) (élettanász) Mena-Segovia, Juan
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM062054
Első szerző:	Petzold, Anne
Cím:	Decoding brain state transitions in the pedunculopontine nucleus : cooperative phasic and tonic mechanisms / Anne Petzold, Miguel Valencia, Balázs Pál, Juan Mena-Segovia
Dátum:	2015
ISSN:	1662-5110
Megjegyzések:	Cholinergic neurons of the pedunculopontine nucleus (PPN) are most active during the waking state. Their activation is deemed to cause a switch in the global brain activity from sleep to wakefulness, while their sustained discharge may contribute to upholding the waking state and enhancing arousal. Similarly, non-cholinergic PPN neurons are responsive to brain state transitions and their activation may influence some of the same targets of cholinergic neurons, suggesting that they operate in coordination. Yet, it is not clear how the discharge of distinct classes of PPN neurons organize during brain states. Here, we monitored the in vivo network activity of PPN neurons in the anesthetized rat across two distinct levels of cortical dynamics and their transitions. We identified a highly structured configuration in PPN network activity during slow-wave activity that was replaced by decorrelated activity during the activated state (AS). During the transition, neurons were predominantly excited (phasically or tonically), but some were inhibited. Identified cholinergic neurons displayed phasic and short latency responses to sensory stimulation, whereas the majority of non-cholinergic showed tonic responses and remained at high discharge rates beyond the state transition. In vitro recordings demonstrate that cholinergic neurons exhibit fast adaptation that prevents them from discharging at high rates over prolonged time periods. Our data shows that PPN neurons have distinct but complementary roles during brain state transitions, where cholinergic neurons provide a fast and transient response to sensory events that drive state transitions, whereas non-cholinergic neurons maintain an elevated firing rate during global activation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban arousal brainstem cholinergic neurons network activity oscillations phasic
Megjelenés:	Frontiers in Neural Circuits. - 9 : 68 (2015), p. 1-16. -
További szerzők:	Valencia, Miguel Pál Balázs (1975-) (élettanász) Mena-Segovia, Juan
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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