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001-es BibID:	BIBFORM018458
Első szerző:	Kecskeméti Valéria
Cím:	Norfluoxetine and fluoxetine have similar anticonvulsant and Ca channel blocking potencies / Kecskeméti V., Rusznák Z., Riba P., Pál B., Wagner R., Harasztosi C., Nánási P. P., Szűcs G.
Dátum:	2005
ISSN:	0361-9230
Megjegyzések:	Norfluoxetine is the most important active metabolite of the widely used antidepressant fluoxetine but little is known about its pharmacological actions. In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models. Pretreatment with fluoxetine or norfluoxetine (20 mg/kg s.c.), as well as phenytoin (30 mg/kg s.c.) and clonazepam (0.1 mg/kg s.c.) significantly increased both the rate and duration of survival, demonstratinga significant protective effect against pentylenetetrazol-induced epilepsy. These effects of norfluoxetine were similar to those of fluoxetine. According to the calculated combined protection scores, both norfluoxetine and fluoxetine were effective from the concentration of 10 mg/kg,while the highest protective action was observed with clonazepam. Effects of norfluoxetine and fluoxetine on voltage-gated Ca2+ channels were evaluated by measuring peak Ba2+ current flowing through the Ca2+ channels upon depolarization using whole cell voltage clamp in enzymatically isolated rat cochlear neurons. The current was reduced equally in a concentration-dependent manner by norfluoxetine (EC50 = 20.4?2.7M, Hill coefficient = 0.86?0.1) and fluoxetine(EC50 = 22.3?3.6M, Hill coefficient = 0.87?0.1). It was concluded that the efficacy of the two compounds in neuronal tissues was equal, either in preventing seizure activity or in blockingthe neuronal Ca2+ channels.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Fluoxetine Norfluoxetine Anticonvulsants Neuronal Ca2+ currents Voltage clamp
Megjelenés:	Brain Research Bulletin. - 67 : 1-2 (2005), p. 126-132. -
További szerzők:	Rusznák Zoltán (1965-) (élettanász) Riba Pál Pál Balázs (1975-) (élettanász) Wagner Róbert Harasztosi Csaba Nánási Péter Pál (1956-) (élettanász) Szűcs Géza (1948-) (élettanász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM018463
Első szerző:	Pál Balázs (élettanász)
Cím:	Depolarization-activated K+ currents of the bushy neurones of the rat cochlear nucleus in a thin brain slice preparation / Pál B., Rusznák Z., Harasztosi C., Szücs G.
Dátum:	2004
Megjegyzések:	Depolarization-activated outward currents of bushy neurones of 6-14-day-old Wistar rats have been investigated in a brain slice preparation. Under current-clamp, the cells produced a single action potential at the beginning of suprathreshold depolarizing current steps. On voltage-clamp depolarizations, the cells produced a mixed outward K+ current that included a component with rapid activation and rapid inactivation, little TEA+ sensitivity, a half-inactivation voltage of -77 +/- 2 mV (T = 25 degrees C; n = 7; Mean +/- S.E.M.) and single-exponential recovery from inactivation (taurecovery= 12 +/- 1 ms at -100 mV; n=3). This transient component was identified as an A-type K+ current. Bushy cells developed a high-threshold TEA-sensitive K+ current that exhibited less prominent inactivation. These characteristics suggested that this current was associated with the activation of delayed rectifier K+ channels. Bushy neurones also possessed a low-threshold outward K+ current that showed partial inactivation and high 4-aminopyridine sensitivity. Part of this current component was blocked by 200 nmol/l dendrotoxin-I. Application of 100 micromol/l 4-aminopyridine changed the firing behaviour of the bushy neurones from the primary-like pattern to a much less rapidly adapting one, suggesting that the low-threshold current might have important roles in maintaining the physiological function of the cells.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban cochlear nucleus bushy cell outward K+ currents dendrotoxin-I 4-aminopyridine
Megjelenés:	Acta Physiologica Hungarica. - 91 : 2 (2004), p. 83-98. -
További szerzők:	Rusznák Zoltán (1965-) (élettanász) Harasztosi Csaba Szűcs Géza (1948-) (élettanász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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