Találati lista | Tudóstér

001-es BibID:	BIBFORM071106
Első szerző:	Fellows, Christopher R.
Cím:	Stem Cells in Bone and Articular Cartilage Tissue Regeneration / Christopher R. Fellows, Kalamegam Gauthaman, Peter N. Pushparaj, Mohammed Abbas, Csaba Matta, Rebecca Lewis, Constanze Buhrmann, Mehdi Shakibaei, Ali Mobasheri
Dátum:	2017
Megjegyzések:	Multiple factors including trauma, infection, ageing, obesity and tumours result in bone and cartilage defects. The regeneration and functional restoration of bone and cartilage remains a significant clinical challenge. ♭Autologous grafts' continue to remain the ♭gold standard' in both bone and cartilage regeneration but stem cell-based therapies offer great promise in both these areas. Despite the plethora of stem cells that exist within the human body, the challenge remains in identifying the most beneficial cell type, assessing their availability, expansion under cGMP culture conditions, differentiation potential and functional restoration capacity. Embryonic stem cells; mesenchymal stem cells from the bone marrow, synovial fluid, adipose tissue and umbilical cord; and primary articular chondrocytes are some of the candidate cell types that are extensively studied in the context of bone (and cartilage) regeneration. The limited regeneration potential of cartilage adds further complexity to cartilage tissue engineering compared to the bone. However, major bone reconstruction as in the case of large bone defects due to tumour resection, fractures, and skeletal deformities is equally challenging. Incorporation of novel biomaterials, understanding the optimal cell-scaffold interactions, the addition of growth factors and provision of molecular cues are all essential in achieving effective tissue regeneration. Intensive effects in tissue regeneration can actually predispose to tissue hypertrophy, which also limits functional capacity. The current state of-the-art in both bone and cartilage regeneration is reviewed in this chapter, which highlights the importance of combined approaches involving stem/progenitor cells, biomolecules and/or biomaterials for therapies as well as rehabilitation and improvement in quality of life.
ISBN:	978-3-319-40144-7
Tárgyszavak:	Orvostudományok Elméleti orvostudományok könyvfejezet
Megjelenés:	Bone and Cartilage Regeneration / Ed. Pham, Phuc Van. - p. 177-204. -
További szerzők:	Gauthaman, Kalamegam Pushparaj, Peter N. Abbas, Mohammed Matta Csaba (1980-) (molekuláris biológus, genetikus, angol szakfordító) Lewis, Rebecca Buhrmann, Constanze Shakibaei, Mehdi Mobasheri, Ali
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM071095
Első szerző:	Richardson, Stephen M.
Cím:	Mesenchymal stem cells in regenerative medicine : focus on articular cartilage and intervertebral disc regeneration / Richardson Stephen M., Kalamegam Gauthaman, Pushparaj Peter N., Matta Csaba, Memic Adnan, Khademhosseini Ali, Mobasheri Reza, Poletti Fabian L., Hoyland Judith A., Mobasheri Ali
Dátum:	2016
ISSN:	1046-2023
Megjegyzések:	Musculoskeletal disorders represent a major cause of disability and morbidity globally and result in enormous costs for health and social care systems. Development of cell-based therapies is rapidly proliferating in a number of disease areas, including musculoskeletal disorders. Novel biological therapies that can effectively treat joint and spine degeneration are high priorities in regenerative medicine. Mesenchymal stem cells (MSCs) isolated from bone marrow (BM-MSCs), adipose tissue (AD-MSCs) and umbilical cord (UC-MSCs) show considerable promise for use in cartilage and intervertebral disc (IVD) repair. This review article focuses on stem cell-based therapeutics for cartilage and IVD repair in the context of the rising global burden of musculoskeletal disorders. We discuss the biology MSCs and chondroprogenitor cells and specifically focus on umbilical cord/Wharton's jelly derived MSCs and examine their potential for regenerative applications. We also summarize key components of the molecular machinery and signaling pathways responsible for the control of chondrogenesis and explore biomimetic scaffolds and biomaterials for articular cartilage and IVD regeneration. This review explores the exciting opportunities afforded by MSCs and discusses the challenges associated with cartilage and IVD repair and regeneration. There are still many technical challenges associated with isolating, expanding, differentiating, and pre-conditioning MSCs for subsequent implantation into degenerate joints and the spine. However, the prospect of combining biomaterials and cell-based therapies that incorporate chondrocytes, chondroprogenitors and MSCs leads to the optimistic view that interdisciplinary approaches will lead to significant breakthroughs in regenerating musculoskeletal tissues, such as the joint and the spine in the near future.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Methods 99 (2016), p. 69-80. -
További szerzők:	Kalamegam, Gauthaman Pushparaj, Peter N. Matta Csaba (1980-) (molekuláris biológus, genetikus, angol szakfordító) Memic, Adnan Khademhosseini, Ali Mobasheri, Reza Poletti, Fabian L. Hoyland, Judith A. Mobasheri, Ali
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: