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001-es BibID:BIBFORM096050
035-os BibID:(cikkazonosító)16731 (WOS)000686708000022 (Scopus)85113135737
Első szerző:Collet, Claude
Cím:Elementary calcium release events in the skeletal muscle cells of the honey bee Apis mellifera / Claude Collet, Mercédès Charreton, Laszlo Szabo, Marianna Takacs, Laszlo Csernoch, Peter Szentesi
Dátum:2021
ISSN:2045-2322
Megjegyzések:Calcium sparks are involved in major physiological and pathological processes in vertebrate muscles but have never been characterized in invertebrates. Here, dynamic confocal imaging on intact skeletal muscle cells isolated enzymatically from the adult honey bee legs allowed the first spatio-temporal characterization of subcellular calcium release events (CREs) in an insect species. The frequency of CREs, measured in x?y time lapse series, was higher than frequencies usually described in vertebrates. Honey bee CREs had a larger spatial spread at half maximum than their vertebrate counterparts and a slightly ellipsoidal shape, two characteristics that may be related to ultrastructural features specific to invertebrate cells. In line-scan experiments, the histogram of CREs' duration followed a bimodal distribution, supporting the existence of both sparks and embers. Unlike in vertebrates, embers and sparks had similar amplitudes, a difference that could be related to genomic differences and/or excitation?contraction coupling specificities in honey bee skeletal muscle fibres. The first characterization of CREs from an arthropod which shows strong genomic, ultrastructural and physiological differences with vertebrates may help in improving the research field of sparkology and more generally the knowledge in invertebrates cell Ca2+ homeostasis, eventually leading to a better understanding of their roles and regulations in muscles but also the myotoxicity of new insecticides targeting ryanodine receptors.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 11 : 1 (2021), p. 16731. -
További szerzők:Charreton, Mercédès Szabó László Takács Marianna (1991-) (állattenyésztés) Csernoch László (1961-) (élettanász) Szentesi Péter (1967-) (élettanász)
Pályázati támogatás:2018-2.1.13-TÉT-FR-2018-00005
Egyéb
TKP2020-IKA-04
Egyéb
2020-4.1.1-TKP2020
Egyéb
PHC Balaton 2019 #41908SC
Egyéb
ANR-13-BSV7-0010
Egyéb
ANR-20-CE34-0017
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM083330
035-os BibID:(cikkazonosító)1707 (WOS)000562809200006 (Scopus)85078884006
Első szerző:Fodor János (élettanász, biotechnológus)
Cím:Improved Calcium Homeostasis and Force by Selenium Treatment and Training in Aged Mouse Skeletal Muscle / János Fodor, Dána Al-Gaadi, Tamás Czirják, Tamás Oláh, Beatrix Dienes, László Csernoch, Péter Szentesi
Dátum:2020
ISSN:2045-2322
Megjegyzések:During aging reduction in muscle mass (sarcopenia) and decrease in physical activity lead to partial loss of muscle force and increased fatigability. Deficiency in the essential trace element selenium might augment these symptoms as it can cause muscle pain, fatigue, and proximal weakness. Average voluntary daily running, maximal twitch and tetanic force, and calcium release from the sarcoplasmic reticulum (SR) decreased while reactive oxygen species (ROS) production associated with tetanic contractions increased in aged ? 22-month-old ? as compared to young ? 4-month-old ? mice. These changes were accompanied by a decline in the ryanodine receptor type 1 (RyR1) and Selenoprotein N content and the increased amount of a degraded RyR1. Both lifelong training and selenium supplementation, but not the presence of an increased muscle mass at young age, were able to compensate for the reduction in muscle force and SR calcium release with age. Selenium supplementation was also able to significantly enhance the Selenoprotein N levels in aged mice. Our results describe, for the first time, the beneficial effects of selenium supplementation on calcium release from the SR and muscle force in old age while point out that increased muscle mass does not improve physical performance with aging.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 10 (2020), p. 1707. -
További szerzők:Al-Gaadi, Dana (1991-) Czirják Tamás Oláh Tamás (1983-) (élettanász) Dienes Beatrix (1972-) (élettanász, molekuláris biológus) Csernoch László (1961-) (élettanász) Szentesi Péter (1967-) (élettanász)
Pályázati támogatás:NKFIH K-115461
NKFIH
GINOP-2.3.2-15-2016-00040
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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