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1.

001-es BibID:BIBFORM030251
035-os BibID:WOS:000182446700007
Első szerző:Bányász Tamás (élettanász)
Cím:Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp / Tamás Bányász, László Fülöp, János Magyar, Norbert Szentandrássy, András Varró, Péter P. Nánási
Dátum:2003
ISSN:0008-6363
Megjegyzések:Objectives: The aim of the present study was to assess and compare the dynamics of L-type Ca2+ current (I-Ca.L) during physiologic action potential (AP) in canine ventricular cardiomyocytes of epicardial (EPI) and endocardial (ENDO) origin. Methods: I-Ca.L was recorded on cells derived from the two regions of the heart using both AP voltage clamp and conventional whole cell voltage clamp techniques. Results: AP voltage clamp experiments revealed that the decay of I-Ca.L is monotonic during endocardial AP, whereas the current is double-peaked (displaying a second rise) during epicardial AP. The amplitude of the first peak was significantly greater in ENDO (-4.6+/-0.8 pA/pF) than in EPI cells (-2.8+/-0.3 pA/pF). Application of epicardial APs as command pulses to endocardial cells yielded double-peaked I-Ca.L profiles, and increased the net charge entry carried by I-Ca.L during the AP from 0.187+/-0.059 to 0.262+/-0.056 pC/pF (n=5, P<0.05). No differences were observed in current densities and inactivation kinetics of I-Ca.L between EPI and ENDO cells when studied under conventional voltage clamp conditions. Nisoldipine shortened action potentials and eliminated the dome of the epicardial AP. Conclusion: I-Ca.L was shown to partially inactivate before and deactivate during phase-1 repolarization and reopening of these channels is responsible for the formation of the dome in canine EPI cells. The transmural differences in the profile of I-Ca.L could be well explained with differences in AP configuration. (C) 2003 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cardiovascular Research. - 58 : 1 (2003), p. 66-75. -
További szerzők:Fülöp László (1976-) (kardiológus) Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
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2.

001-es BibID:BIBFORM030249
035-os BibID:WOS:000187895800005
Első szerző:Bányász Tamás (élettanász)
Cím:Profile of I(Ks) during the action potential questions the therapeutic value of I(Ks) blockade / Tamás Bányász, Roland Koncz, László Fülöp, Norbert Szentandrássy, János Magyar, Péter P. Nánási
Dátum:2004
ISSN:0929-8673
Megjegyzések:The goal of this paper is two fold. First, we attempt to review the reports available on the role Of I-Ks in myocardial repolarization. Based on theoretical considerations and experimental results, it seems reasonable to assume that I-Ks blockade will lengthen the action potential. However, results obtained with I-Ks blockers, like chromanol 293B or L-735,821, are conflicting, since from slight lengthening to marked prolongation of action potentials were equally obtained. Although these contradictory results were explained by interspecies or regional differences, the role Of I-Ks in repolarization is a matter of growing dispute. In the second part of this study, we simulated the performance Of I-Ks during cardiac action potentials. We compared the profile of the predicted current in three mathematical models in order to determine the relative role of the current in repolarization. We studied the effect of the cycle length, action potential duration and height of the plateau on the profile Of I-Ks in epicardiac, endocardiac and midmyocardiac ventricular action potentials. The results indicate that the height of the plateau is the most important parameter to control activation Of I-Ks in cardiac tissues, and accordingly, the interspecies and regional differences observed in the efficacy Of I-Ks blockers are likely due to the known differences in action potential morphology. We conclude also that I-Ks blockade may have unpredictable effects on the length of the action potential in a diseased heart, questioning the possible therapeutic value of drugs blocking I-Ks.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Current Medicinal Chemistry. - 11 : 1 (2004), p. 45-60. -
További szerzők:Koncz Roland Fülöp László (1976-) (kardiológus) Szentandrássy Norbert (1976-) (élettanász) Magyar János (1961-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
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3.

001-es BibID:BIBFORM030260
035-os BibID:WOS:000187507900005
Első szerző:Fülöp László (kardiológus)
Cím:The role of transmembrane chloride current in afterdepolarisations in canine ventricular cardiomyocytes / L. Fülöp, E. Fiák, N. Szentandrássy, J. Magyar, P. P. Nánási, T. Bányász
Dátum:2003
ISSN:0231-5882
Megjegyzések:The physiological role of chloride currents (I-Cl) in cardiac cells is poorly understood. The aim of the present study was to reveal the role of I-Cl in the genesis of early and delayed afterdepolarisations (EADs and DADs, respectively). First we identified I-Cl under action potential voltage clamp conditions as the anthracene-9-carboxylic acid (ANTRA) (0.5 mmol/l)-sensitive current. The ANTRA-sensitive current was large and outwardly directed at the beginning, while it was moderate and inwardly directed at the end of the action potential. Application of ANTRA under current clamp conditions decreased the depth of the incisura, shifted the plateau upwards and lengthened the duration of action potentials. The effect of ANTRA was studied in three models of afterdepolarisations: the ouabain-induced DAD model, the caesium-induced EAD model, and in the presence of subthreshold concentration of isoproterenol. Preincubation of the cells with 0.5 mmol/l ANTRA failed to induce afterdepolarisations. Ouabain (200 nmol/l) alone caused DADs in 62.5 % of the cells within 15 min. When ouabain was applied in the presence of ANTRA, 60 % of the myocytes transiently displayed EADs before the development of DADs, and all cells developed DADs within 7 min. Isoproterenol (5 nmol/l) alone failed to induce afterdepolarisations. However, 75 % of the cells produced DADs within 6 min when superfused with isoproterenol in the presence of ANTRA. Incubation of the myocytes with 3.6 mmol/l CsCl caused EADs in 71.4 % of the cells within 30 min. Application of CsCl in the presence of ANTRA resulted in immediate depolarisation of the membrane from -79.6 +/- 0.4 to -54.2 +/- 3.5 mV. Summarizing our results we conclude that the ANTRA-sensitive current is an important mechanism of defence against afterdepolarisations. Suppression of I-Cl may thus increase the incidence and accelerate the rate of development of both EADs and DADs.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Physiology and Biophysics. - 22 : 3 (2003), p. 341-353. -
További szerzők:Fiák Edit Szentandrássy Norbert (1976-) (élettanász) Magyar János (1961-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Bányász Tamás (1960-) (élettanász)
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4.

001-es BibID:BIBFORM030250
035-os BibID:WOS:000182475600002
Első szerző:Fülöp László (kardiológus)
Cím:Differences in electrophysiological and contractile properties of mammalian cardiac tissues bathed in bicarbonate - and HEPES-buffered solutions / L. Fülöp, G. Szigeti, J. Magyar, N. Szentandrássy, T. Ivanics, Z. Miklós, L. Ligeti, A. Kovács, G. Szénási, L. Csernoch, P. P. Nánási, T. Bányász
Dátum:2003
ISSN:0001-6772
Megjegyzések:Aim: The aim of this study was to compare the action potential configuration, contractility, intracellular Ca2+ and H+ concentrations in mammalian cardiac tissues bathed with Krebs and Tyrode solutions at 37 degreesC. Results: In Langendorff-perfused guinea-pig hearts, loaded with the fluorescent Ca2+ -indicator Fura-2, or H+ -sensitive dye carboxy-SNARF, shifts from Krebs to Tyrode solution caused intra-cellular acidification, increased diastolic pressure and [Ca2+ ](i) , decreased systolic pressure and [Ca2+ ](i) , leading to a reduction in the amplitude of [Ca2+ ](i) transients and pulse pressure. Contractility was also depressed in canine ventricular trabeculae when transferred from Krebs to Tyrode solution. Shifts from Krebs to Tyrode solution increased the duration of action potentials in multicellular cardiac preparations excised from canine and rabbit hearts but not in isolated cardiomyocytes. All these changes in action potential morphology, contractility, [Ca2+ ](i) and [H+ ](i) were readily reversible by addition of 26 mmol L-1 bicarbonate to Tyrode solution. Effects of dofetilide and CsCl, both blockers of the delayed rectifier K current, on action potential duration were compared in Krebs and Tyrode solutions. Dofetilide lengthened rabbit ventricular action potentials in a significantly greater extent in Tyrode than in Krebs solution. Exposure of canine Purkinje fibres to CsCl evoked early after depolarizations within 40 min in all preparations incubated with Tyrode solution, but not in those bathed with Krebs solution. Conclusion: It is concluded that the marked differences in action potential morphology, [Ca2+ ](i) , [H+ ](i) and contractility observed between preparations bathed with Krebs and Tyrode solutions are more likely attributable to differences in the intracellular buffering capacities of the two media.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Scandinavica. - 178 : 1 (2003), p. 11-18. -
További szerzők:Szigeti Gyula (1969-) (élettanász, elektrofiziológus) Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Ivanics Tamás Miklós Zsuzsanna Ligeti László Kovács A. Szénási Gábor Csernoch László (1961-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Bányász Tamás (1960-) (élettanász)
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5.

001-es BibID:BIBFORM030248
035-os BibID:WOS:000187850300006
Első szerző:Fülöp László (kardiológus)
Cím:Reopening of L-type calcium channels in human ventricular myocytes during applied epicardial action potentials / L. Fülöp, T. Bányász, J. Magyar, N. Szentandrássy, A. Varró, P. P. Nánási
Dátum:2004
ISSN:0001-6772
Megjegyzések:Aims: Present study was performed to compare the dynamics of human L-type calcium current (I-Ca,I-L) flowing during rectangular voltage pulses, voltage ramps, and action potentials (APs) recorded from epicardiac and endocardiac canine ventricular cells. Methods: I-Ca,I-L was recorded in single myocytes isolated from undiseased human hearts using the whole cell voltage clamp technique. Results: The decay of I-Ca,I-L was monotonic when using rectangular pulses or endocardial APs as voltage commands, whereas the current became double-peaked (displaying a second rise and fall) during epicardial (EPI) APs or voltage ramps used to mimic EPI APs. These I-Ca,I-L profiles were associated with single-hooked and double-hooked phase-plane trajectories, respectively. No sustained current was observed during the AP commands. Kinetics of deactivation and recovery from inactivation of human I-Ca,I-L were determined using twin-pulse voltage protocols and voltage ramps, and the results were similar to those obtained previously in canine cells under identical experimental conditions. Conclusions: I-Ca,I-L can inactivate partially before and deactivate during the phase-1 repolarization of the epicardiac AP, and reopening of these channels seems to be associated with formation of the dome.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Scandinavica. - 180 : 1 (2004), p. 39-47. -
További szerzők:Bányász Tamás (1960-) (élettanász) Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
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6.

001-es BibID:BIBFORM001043
Első szerző:Gönczi Mónika (élettanász)
Cím:Hypotonic stress influence the membrane potential and alter the proliferation of keratinocytes in vitro / Gönczi M., Szentandrássy N., Fülöp L., Telek A., Szigeti G. P., Magyar J., Bíró T., Nánási P. P., Csernoch L.
Dátum:2007
ISSN:0906-6705 (Print)
Megjegyzések:Keratinocyte proliferation and differentiation is strongly influenced by mechanical forces. We investigated the effect of osmotic changes in the development of HaCaT cells in culture using intracellular calcium measurements, electrophysiological recordings and molecular biology techniques. The application of hypotonic stress (174 mOsmol/l) caused a sustained hyperpolarization of HaCaT cells from a resting potential of -27 +/- 4 to -51 +/- 9 mV. This change was partially reversible. The surface membrane channels involved in the hyperpolarization were identified as chloride channels due to the lack of response in the absence of the anion. Cells responded with an elevation of intracellular calcium concentration to hypotonic stress, which critically depended on external calcium. The presence of phorbol-12-myristate-13-acetate in the culture medium for 12 h augmented the subsequent response to hypotonic stress. A sudden switch from iso- to hypotonic solution increased cell proliferation and suppressed the production of involucrin, filaggrin and transglutaminase, markers of keratinocyte differentiation. It is concluded that sudden mechanical forces increase the proliferation of keratinocytes through alterations in their membrane potential and intracellular calcium concentration. These changes together with additional modifications in channel expression and intracellular signalling mechanisms could underlie the increased proliferation of keratinocytes in hyperproliferative skin diseases.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Experimental Dermatology. - 16 (2007), p. 302-310. -
További szerzők:Szentandrássy Norbert (1976-) (élettanász) Fülöp László (1976-) (kardiológus) Telek Andrea (1977-) (élettanász) Szigeti Gyula (1969-) (élettanász, elektrofiziológus) Magyar János (1961-) (élettanász) Bíró Tamás (1968-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Csernoch László (1961-) (élettanász)
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7.

001-es BibID:BIBFORM030259
035-os BibID:WOS:000175824200020
Első szerző:Magyar János (élettanász)
Cím:Effects of thymol on calcium and potassium currents in canine and human ventricular cardiomyocytes / János Magyar, Norbert Szentandrássy, Tamás Bányász, László Fülöp, András Varró, Péter P. Nánási
Dátum:2002
ISSN:0007-1188
Megjegyzések:1 Concentration-dependent effects of thymol (1 - 1000 pm) was Studied on action potential configuration and ionic currents in isolated canine ventricular cardiomyocytes using conventional microelectrode and patch clamp techniques. 2 Low concentration of thymol (10 muM) removed the notch of the action potential, whereas high concentrations (100 pm or higher) caused an additional shortening of action potential duration accompanied by progressive depression of plateau and reduction of V-max. 3 In the canine cells L-type Ca current (I-Ca) was decreased by thymol in a concentration-dependent manner (EC50: 158 +/- 7 muM, Hill coeff.: 2.96+/-0.43). In addition. thymol (50 - 250 muM) accelerated the inactivation of I-Ca, increased the time constant of recovery from inactivation, shifted the steady-state inactivation curve of I-Ca leftwards, but voltage dependence of activation remained unaltered. Qualitatively similar results were obtained with thymol in ventricular myocytes isolated from healthy human hearts. 4 Thymol displayed concentration-dependent suppressive effects on potassium currents: the transient outward current, I-10 (EC50: 60.6 +/- 11.4 muM, Hill coeff.: 1.03 +/- 0.11), the rapid component of the delayed rectifier, I-Kr (EC50: 63.4 +/- 6.1 muM, Hill coeff.: 1.29 +/- 0.15), and the slow component of the delayed rectifiers I-Ks (EC50: 202+/-11 muM, Hill coeff.: 0.72+/-0.14), however, K channel kinetics were not much altered by thymol. These effects on Ca and K Currents developed rapidly (within 0.5 min) and were readily reversible. 5 In conclusion, thymol suppressed cardiac ionic channels in a concentration-dependent manner, however, both drug-sensitivities as well as the mechanism of action seems to be different when blocking calcium and potassium channels.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:British Journal of Pharmacology. - 136 : 2 (2002), p. 330-338. -
További szerzők:Szentandrássy Norbert (1976-) (élettanász) Bányász Tamás (1960-) (élettanász) Fülöp László (1976-) (kardiológus) Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
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8.

001-es BibID:BIBFORM030257
035-os BibID:WOS:000169039300004
Első szerző:Magyar János (élettanász)
Cím:Effects of the antiarrhythmic agent EGIS-7229 (S 21407) on calcium and potassium currents in canine ventricular cardiomyocytes / János Magyar, Tamás Bányász, László Fülöp, Norbert Szentandrássy, Ágnes Körtvély, Anikó Kovács, Gábor Szénási, Péter P. Nánási
Dátum:2001
ISSN:0028-1298
Megjegyzések:Based on earlier pharmacological studies performed using conventional microelectrodes EGIS-7229 (S 21407), the novel antiarrhythmic candidate, was suggested to have a combined mode of action in cardiac tissues isolated from various mammalian species. In order to characterize the electrophysiological effects of the compound, its effects on calcium and potassium currents of isolated canine ventricular cardiomyocytes were studied in the present work using the whole cell configuration of the patch clamp technique. L-type Ca current (I-Ca) was significantly depressed by EGIS-7229 at concentrations of 3 muM or higher with no concomitant changes in the voltage-dependence of activation and time course of inactivation of I-Ca. The drug reversibly suppressed the rapid component of the delayed rectifier K current (I-Kr) in a concentration-dependent manner, having a K-0.5 value of 1.1+/-0.1 muM and a slope factor of close to unity (1.23+/-0.16), indicating that probably one single binding site of high affinity may be involved in binding of EGIS-7229 to the I-Kr channel. In contrast, no changes in the slow component of the delayed rectifier K current (I-Ks,) was observed with the compound up to the concentration of 100 muM, even if the current was fully activated by 8-bromo-cAMP. At a concentration of 10 muM or higher, EGIS-7229 caused also a moderate but significant reduction in the inward rectifier K current (I-K1) and the transient outward K current (I-to) with no change in the voltage-dependence of activation and steady-state inactivation of I-to. Present results indicate that EGIS-7229 can be considered as a selective I-Kr blocker at low (1 muM) concentration; however, its combined (class III + IV) mechanism of action is evident at concentrations of 3 muM or higher. Suppression of I-Ca may explain the lack of development of early afterdepolarizations in the presence of EGIS-7229, predicting a relatively safe clinical application in contrast to pure class III compounds.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Naunyn-Schmiedebergs Archives of Pharmacology. - 363 : 6 (2001), p. 604-611. -
További szerzők:Bányász Tamás (1960-) (élettanász) Fülöp László (1976-) (kardiológus) Szentandrássy Norbert (1976-) (élettanász) Körtvély Ágnes Kovács Anikó Szénási Gábor Nánási Péter Pál (1956-) (élettanász)
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9.

001-es BibID:BIBFORM030256
035-os BibID:WOS:000178499200009
Első szerző:Magyar János (élettanász)
Cím:Electrophysiological effects of risperidone in mammalian cardiac cells / János Magyar, Tamás Bányász, Zsolt Bagi, Pál Pacher, Norbert Szentandrássy, László Fülöp, Valéria Kecskeméti, Péter P. Nánási
Dátum:2002
ISSN:0028-1298
Megjegyzések:In this study, the effects of risperidone, the widely used antipsychotic drug, on isolated canine ventricular myocytes and guinea-pig papillary muscles were analyzed using conventional microelectrode and whole cell voltage-clamp techniques. Risperidone concentration-dependently lengthened action potential duration in guinea-pig papillary muscles (EC50=0.29 +/- 0.02 muM) and single canine ventricular myocytes (EC50=0.48 +/- 0.14 muM). This effect was reversible, showed reverse rate dependence, and it was most prominent on the terminal portion of repolarization. No significant effect of risperidone on the resting membrane potential, action potential amplitude or maximum rate of depolarization was observed. In voltage-clamped canine ventricular myocytes risperidone caused concentration-dependent block of the rapid component of the delayed rectifier K+ current (1(Kr)), measured as outward current tails at -40 mV with an IC50 of 0.92 +/- 0.26 muM. Suppression of I-Kr was not associated with changes in activation or deactivation kinetics. High concentration of risperidone (10 muM) suppressed also the slow component of the delayed rectifier K+ current (I-Ks) by 9.6 +/- 1.5% at +50 mV. These effects of risperidone developed rapidly and were readily reversible. Risperidone had no significant effect on the amplitude of other K+ currents (I-K1 and I-to). The inhibition of cardiac I-Kr current by risperidone may explain the cardiac side-effects observed occasionally with the drug. Our results suggest that risperidone displays class III antiarrhythmic properties, and as such, may produce QTc prolongation, especially in patients with long QT syndrome. Therefore, in psychotic patients having also cardiac disorders, ECG control may be suggested during risperidone therapy.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Naunyn-Schmiedebergs Archives of Pharmacology. - 366 : 4 (2002), p. 350-356. -
További szerzők:Bányász Tamás (1960-) (élettanász) Bagi Zsolt (1974-) (orvos) Pacher Pál Szentandrássy Norbert (1976-) (élettanász) Fülöp László (1976-) (kardiológus) Kecskeméti Valéria Nánási Péter Pál (1956-) (élettanász)
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10.

001-es BibID:BIBFORM030245
035-os BibID:WOS:000220687400004
Első szerző:Magyar János (élettanász)
Cím:Effects of terpenoid phenol derivatives on calcium current in canine and human ventricular cardiomyocytes / János Magyar, Norbert Szentandrassy, Tamás Banyasz, László Fülöp, András Varro, Péter P. Nanasi
Dátum:2004
ISSN:0014-2999
Megjegyzések:Concentration-dependent (10-1000 muM) effects of terpenoid phenol derivatives were studied on L-type Ca2+ current in isolated canine and human ventricular cardiomyocytes using the whole-cell configuration of patch clamp technique. Carvacrol, thymol and eugenol suppressed peak Ca2+ current at +5 mV, having EC50 values and Hill coefficients of 98 +/- 11, 158 +/- 7 and 187 +/- 15 muM and 1.42 +/- 0.05, 2.96 +/- 0.43 and 1.6 +/- 0.1, respectively, in canine myocytes. Zingerone displayed a weak effect (estimated EC50: 2 +/- 0.37 mM, Hill coefficient: 0.73 +/- 0.07), while vanillin and guaiacol failed to substantially modify Ca2+ current up to the concentration of I mM. In addition to tonic block, thymol and carvacrol, but not eugenol, evoked marked rate-dependent block at 2 Hz. Carvacrol and eugenol accelerated inactivation of Ca2+ current and caused leftward shift in the voltage dependence of steady-state inactivation without altering activation kinetics. Carvacrol, but not eugenol, increased the time constant of recovery from inactivation. These effects of carvacrol and eugenol developed rapidly and were largely reversible. In myocytes isolated from undiseased human hearts, the effect of carvacrol was similar to that observed in canine cells. It is concluded that suppression of cardiac Ca2+ currents by phenol derivatives is influenced by the substituent in the benzene ring, and the blocking effect of these drugs may involve interactions with the inactivation machinery of the channel. (C) 2004 Elsevier B.V. All rights reserved.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Pharmacology. - 487 : 1-3 (2004), p. 29-36. -
További szerzők:Szentandrássy Norbert (1976-) (élettanász) Bányász Tamás (1960-) (élettanász) Fülöp László (1976-) (kardiológus) Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
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