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001-es BibID:	BIBFORM115334
035-os BibID:	(WoS)001078071300001
Első szerző:	Hum, Ryan Malcolm
Cím:	Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis : results from the MYONET registry / Hum Ryan Malcolm, Lilleker James B., Lamb Janine A., Oldroyd Alexander G. S., Wang Guochun, Wedderburn Lucy R., Diederichsen Louise P., Schmidt Jens, Danieli Maria Giovanna, Oakley Paula, Griger Zoltan, Nguyen Thi Phuong Thuy, Kodishala Chanakya, Vazquez-Del Mercado Monica, Andersson Helena, De Paepe Boel, De Bleecker Jan L., Maurer Britta, McCann Liza, Pipitone Nicolo, McHugh Neil, New Robert Paul, Ollier William E., Krogh Niels Steen, Vencovsky Jiri, Lundberg Ingrid E., Chinoy Hector, MYONET Registry
Dátum:	2023
ISSN:	1462-0324 1462-0332
Megjegyzések:	Objectives: To compare clinical characteristics, including the frequency of cutaneous, extramuscular manifestations, and malignancy, between adults with anti-synthetase syndrome (ASyS) and dermatomyositis (DM). Methods: Using data regarding adults from the MYONET registry, a cohort of DM patients with anti-Mi2/-TIF1?/-NXP2/-SAE/-MDA5 autoantibodies, and a cohort of ASyS patients with anti-tRNA synthetase autoantibodies (anti-Jo1/-PL7/-PL12/-OJ/-EJ/-Zo/-KS) were identified. Patients with DM sine dermatitis or with discordant dual autoantibody specificities were excluded. Sub-cohorts of patients with ASyS with or without skin involvement were defined based on presence of DM-type rashes (heliotrope rash, Gottron's papules/sign, violaceous rash, shawl sign, V sign, erythroderma, and/or periorbital rash). Results: In total 1,054 patients were included (DM, n = 405; ASyS, n = 649). In ASyS cohort, 31% (n = 203) had DM-type skin involvement (ASyS-DMskin). A higher frequency of extramuscular manifestations, including Mechanic's hands, Raynaud's phenomenon, arthritis, interstitial lung disease, and cardiac involvement differentiated ASyS-DMskin from DM (all p< 0.001), whereas higher frequency of any of four DM-type rashes: heliotrope rash (n = 248, 61% vs n = 90, 44%), violaceous rash (n = 166, 41% vs n = 57, 9%), V sign (n = 124, 31% vs n = 28, 4%), and shawl sign (n = 133, 33% vs n = 18, 3%) differentiated DM from ASyS-DMskin (all p< 0.005). Cancer-associated myositis (CAM) was more frequent in DM (n = 67, 17%) compared with ASyS (n = 21, 3%) and ASyS-DMskin (n = 7, 3%) cohorts (both p< 0.001). Conclusion: DM-type rashes are frequent in patients with ASyS; however, distinct clinical manifestations differentiate these patients from classical DM. Skin involvement in ASyS does not necessitate increased malignancy surveillance. These findings will inform future ASyS classification criteria and patient management.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Antisynthetase syndrome MYONET Raynaud's phenomenon cutaneous dermatomyositis epidemiology extramuscular malignancy rashes skin
Megjelenés:	Rheumatology. - [Epub ahead of print] (2023). -
További szerzők:	Lilleker, James B. Lamb, Janine A. Oldroyd, Alexander Wang, Guochun Wedderburn, Lucy R. Diederichsen, Louise Pyndt Schmidt, Jens Danieli, Maria Giovanna Oakley, Paula Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nguyen, Thi Le Phuong Kodishala, Chanakya Vazquez-Del Mercado, Monica Andersson, Helena De Paepe, Boel De Bleecker, Jan Maurer, Britta McCann, Liza J. Pipitone, Nicolo McHugh, Neil New, Robert Paul Ollier, William E. Krogh, Niels Steen Vencovsky, Jiri Lundberg, Ingrid Chinoy, Hector MYONET Registry
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001-es BibID:	BIBFORM117991
035-os BibID:	(cikkazonosító)152379 (scopus)85184773277
Első szerző:	Lodin, Karin
Cím:	Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies : a longitudinal study / Lodin Karin, Espinosa-Ortega Fabricio, Dastmalchi Maryam, Vencovsky Jiri, Andersson Helena, Chinoy Hector, Lilleker James B., Shinjo Samuel Katsuyuki, Maurer Britta, Griger Zoltan, Ceribelli Angela, Torres-Ruiz Jiram, Mercado Mónica Vázquez-Del, Leonard Dag, Alexanderson Helene, Lundberg Ingrid E.
Dátum:	2024
ISSN:	0049-0172
Megjegyzések:	Aim : To explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM). Methods : PGA and systemic inflammatory markers prospectively collected over five years were retrieved from the International MyoNet registry for 1200 patients with IIM. Associations between PGA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and creatine kinase (CK) were analysed using mixed models. Mediation analysis was used to test if the association between PGA and inflammatory markers during the first year of observation could be explained by measures of disease activity and function. Results : PGA improved, and inflammatory markers decreased during the first year of observation. In the mixed models, high levels of inflammatory markers were associated with worse PGA in both men and women across time points during five years of observation. In men, but not in women, the association between elevated ESR, CRP and poorer PGA was explained by measures of function and disease activity. With a few exceptions, the association between improved PGA and reduced inflammatory markers was partially mediated by improvements in all measures of function and disease activity. Conclusion : Increased levels of systemic inflammation are associated with poorer PGA in patients with IIM. In addition to known benefits of lowered inflammation, these findings emphasize the need to reduce systemic inflammation to improve subjective health in patients with IIM. Furthermore, the results demonstrate the importance of incorporating PGA as an outcome measure in clinical practice and clinical trials.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Idiopathic inflammatory myopathies myositis patient reported outcome measures inflammation
Megjelenés:	Seminars In Arthritis And Rheumatism. - 65 (2024), p. 1-10. -
További szerzők:	Espinosa-Ortega, Fabricio Dastmalchi, Maryam Vencovsky, Jiri Andersson, Helena Chinoy, Hector Lilleker, James B. Shinjo, Samuel Katsuyuki Maurer, Britta Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Ceribelli, Angela Torres-Ruiz, Jiram Mercado, Mónica Vázquez-Del Leonard, Dag Alexanderson, Helene Lundberg, Ingrid
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