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001-es BibID:	BIBFORM115334
035-os BibID:	(WoS)001078071300001
Első szerző:	Hum, Ryan Malcolm
Cím:	Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis : results from the MYONET registry / Hum Ryan Malcolm, Lilleker James B., Lamb Janine A., Oldroyd Alexander G. S., Wang Guochun, Wedderburn Lucy R., Diederichsen Louise P., Schmidt Jens, Danieli Maria Giovanna, Oakley Paula, Griger Zoltan, Nguyen Thi Phuong Thuy, Kodishala Chanakya, Vazquez-Del Mercado Monica, Andersson Helena, De Paepe Boel, De Bleecker Jan L., Maurer Britta, McCann Liza, Pipitone Nicolo, McHugh Neil, New Robert Paul, Ollier William E., Krogh Niels Steen, Vencovsky Jiri, Lundberg Ingrid E., Chinoy Hector, MYONET Registry
Dátum:	2023
ISSN:	1462-0324 1462-0332
Megjegyzések:	Objectives: To compare clinical characteristics, including the frequency of cutaneous, extramuscular manifestations, and malignancy, between adults with anti-synthetase syndrome (ASyS) and dermatomyositis (DM). Methods: Using data regarding adults from the MYONET registry, a cohort of DM patients with anti-Mi2/-TIF1?/-NXP2/-SAE/-MDA5 autoantibodies, and a cohort of ASyS patients with anti-tRNA synthetase autoantibodies (anti-Jo1/-PL7/-PL12/-OJ/-EJ/-Zo/-KS) were identified. Patients with DM sine dermatitis or with discordant dual autoantibody specificities were excluded. Sub-cohorts of patients with ASyS with or without skin involvement were defined based on presence of DM-type rashes (heliotrope rash, Gottron's papules/sign, violaceous rash, shawl sign, V sign, erythroderma, and/or periorbital rash). Results: In total 1,054 patients were included (DM, n = 405; ASyS, n = 649). In ASyS cohort, 31% (n = 203) had DM-type skin involvement (ASyS-DMskin). A higher frequency of extramuscular manifestations, including Mechanic's hands, Raynaud's phenomenon, arthritis, interstitial lung disease, and cardiac involvement differentiated ASyS-DMskin from DM (all p< 0.001), whereas higher frequency of any of four DM-type rashes: heliotrope rash (n = 248, 61% vs n = 90, 44%), violaceous rash (n = 166, 41% vs n = 57, 9%), V sign (n = 124, 31% vs n = 28, 4%), and shawl sign (n = 133, 33% vs n = 18, 3%) differentiated DM from ASyS-DMskin (all p< 0.005). Cancer-associated myositis (CAM) was more frequent in DM (n = 67, 17%) compared with ASyS (n = 21, 3%) and ASyS-DMskin (n = 7, 3%) cohorts (both p< 0.001). Conclusion: DM-type rashes are frequent in patients with ASyS; however, distinct clinical manifestations differentiate these patients from classical DM. Skin involvement in ASyS does not necessitate increased malignancy surveillance. These findings will inform future ASyS classification criteria and patient management.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Antisynthetase syndrome MYONET Raynaud's phenomenon cutaneous dermatomyositis epidemiology extramuscular malignancy rashes skin
Megjelenés:	Rheumatology. - [Epub ahead of print] (2023). -
További szerzők:	Lilleker, James B. Lamb, Janine A. Oldroyd, Alexander Wang, Guochun Wedderburn, Lucy R. Diederichsen, Louise Pyndt Schmidt, Jens Danieli, Maria Giovanna Oakley, Paula Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nguyen, Thi Le Phuong Kodishala, Chanakya Vazquez-Del Mercado, Monica Andersson, Helena De Paepe, Boel De Bleecker, Jan Maurer, Britta McCann, Liza J. Pipitone, Nicolo McHugh, Neil New, Robert Paul Ollier, William E. Krogh, Niels Steen Vencovsky, Jiri Lundberg, Ingrid Chinoy, Hector MYONET Registry
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM116491
035-os BibID:	(wos)001103143700001 (scopus)85176609027
Első szerző:	Oldroyd, Alexander
Cím:	International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening : an International Myositis Assessment and Clinical Studies Group (IMACS) initiative / Alexander G. S. Oldroyd, Jeffrey P. Callen, Hector Chinoy, Lorinda Chung, David Fiorentino, Patrick Gordon, Pedro M. Machado, Neil McHugh, Albert Selva-O'Callaghan, Jens Schmidt, Sarah L. Tansley, Ruth Ann Vleugels, Victoria P. Werth, International Myositis Assessment and Clinical Studies Group Cancer Screening Expert Group, Rohit Aggarwal
Dátum:	2023
ISSN:	1759-4790 1759-4804
Megjegyzések:	Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within the 3 years preceding and following IIM onset. Evidence- and consensus-based recommendations for IIM-associated cancer screening can potentially improve outcomes. This International Guideline for IIM-Associated Cancer Screening provides recommendations addressing IIM-associated cancer risk stratification, cancer screening modalities and screening frequency. The international Expert Group formed a total of 18 recommendations via a modified Delphi approach using a series of online surveys. First, the recommendations enable an individual patient's IIM-associated cancer risk to be stratified into standard, moderate or high risk according to the IIM subtype, autoantibody status and clinical features. Second, the recommendations outline a 'basic' screening panel (including chest radiography and preliminary laboratory tests) and an 'enhanced' screening panel (including CT and tumour markers). Third, the recommendations advise on the timing and frequency of screening via basic and enhanced panels, according to risk status. The recommendations also advise consideration of upper or lower gastrointestinal endoscopy, nasoendoscopy and 18F-FDG PET-CT scanning in specific patient populations. These recommendations are aimed at facilitating earlier IIM-associated cancer detection, especially in those who are at a high risk, thus potentially improving outcomes, including survival.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Nature Reviews Rheumatology. - 19 : 12 (2023), p. 805-817. -
További szerzők:	Callen, Jeffrey P. Chinoy, Hector Chung, Lorinda Fiorentino, David Gordon, Patrick Machado, Pedro M. McHugh, Neil Selva-O'Callaghan, Albert Schmidt, Jens Tansley, Sarah Vleugels, Ruth Ann Werth, Victoria P. Aggarwal, Rohit Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy-Vincze Melinda (1985-) (orvos) International Myositis Assessment and Clinical Studies Group Cancer Screening Expert Group
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