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001-es BibID:	BIBFORM040781
Első szerző:	Acquaviva, Laurent
Cím:	The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination / Laurent Acquaviva, Lóránt Székvölgyi, Bernhard Dichtl, Beatriz Solange Dichtl, Christophe de La Roche Saint André, Alain Nicolas, Vincent Géli
Dátum:	2013
ISSN:	0036-8075
Megjegyzések:	During meiosis, combinatorial associations of genetic traits arise from homologous recombination between parental chromosomes. Histone H3 lysine 4 trimethylation marks meiotic recombination hotspots in yeast and mammals, but how this ubiquitous chromatin modification relates to the initiation of double-strand breaks (DSBs) dependent on Spo11 remains unknown. Here, we show that the tethering of a PHD-containing protein, Spp1 (a component of the COMPASS complex), to recombinationally cold regions is sufficient to induce DSB formation. Furthermore, we found that Spp1 physically interacts with Mer2, a key protein of the differentiated chromosomal axis required for DSB formation. Thus, by interacting with H3K4me3 and Mer2, Spp1 promotes recruitment of potential meiotic DSB sites to the chromosomal axis, allowing Spo11 cleavage at nearby nucleosome-depleted regions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban meiotic recombination histone modification Spp1 chromatin loop ASSOCIATION Chromatin Chromosomes Chromosomes, Fungal DNA Breaks, Double-Stranded DNA-Binding Proteins Endodeoxyribonucleases genetics Histones Lysine Meiosis metabolism Methylation Protein Subunits Proteins recombination Recombination, Genetic Research Research Support Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Spo11 Support
Megjelenés:	Science. - 339 : 6116 (2013), p. 215-218. -
További szerzők:	Székvölgyi Lóránt (1977-) (biofizikus, biokémikus, sejtbiológus) Dichtl, Bernhard Dichtl, Beatriz Solange Saint André, Christophe, de La Roche Nicolas, Alain Géli, Vincent
Pályázati támogatás:	OTKA-PD Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM057693
Első szerző:	Székvölgyi Lóránt (biofizikus, biokémikus, sejtbiológus)
Cím:	Initiation of meiotic homologous recombination : flexibility, impact of histone modifications, and chromatin remodeling / Lóránt Székvölgyi, Kunihiro Ohta, Alain Nicolas
Dátum:	2015
Megjegyzések:	Meiotic recombination is initiated by the formation of DNA double-strand breaks (DSBs)catalyzed by the evolutionary conserved Spo11 protein and accessory factors. DSBs arenonrandomly distributed along the chromosomes displaying a significant ( 400-fold) variationof frequencies, which ultimately establishes local and long-range "hot" and "cold"domains for recombination initiation. This remarkable patterning is set up within the chromatincontext, involving multiple layers of biochemical activity. Predisposed chromatinaccessibility, but also a range of transcription factors, chromatin remodelers, and histonemodifiers likely promote local recruitment of DSB proteins, as well as mobilization, sliding,and eviction of nucleosomes before and after the occurrence of meiotic DSBs. Here, weassess our understanding of meiotic DSB formation and methods to change its patterning.Wealso synthesize current heterogeneous knowledge on how histone modifications and chromatinremodeling may impact this decisive step in meiotic recombination.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban rekombináció kromatin szerkezet hiszton modifikáció DSB
Megjelenés:	Cold Spring Harbor Perspectives in Biology. - 7 : 5 (2015), p. 1-16. -
További szerzők:	Ohta, Kunihiro Nicolas, Alain
Pályázati támogatás:	TÁMOP-4.2.4.A/2-11/1- 2012-0001 TÁMOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM015626
Első szerző:	Székvölgyi Lóránt (biofizikus, biokémikus, sejtbiológus)
Cím:	From meiosis to postmeiotic events: Homologous recombination is obligatory but flexible / Szekvolgyi, L., Nicolas, A.
Dátum:	2010
Megjegyzések:	Sexual reproduction depends on the success of faithful chromosome transmission during meiosis to yield viable gametes. Central to meiosis is the process of recombination between paternal and maternal chromosomes, which boosts the genetic diversity of progeny and ensures normal homologous chromosome segregation. Imperfections in meiotic recombination are the source of de novo germline mutations, abnormal gametes, and infertility. Thus, not surprisingly, cells have developed a variety of mechanisms and tight controls to ensure sufficient and well-distributed recombination events within their genomes, the details of which remain to be fully elucidated. Local and genome-wide studies of normal and genetically engineered cells have uncovered a remarkable stochasticity in the number and positioning of recombination events per chromosome and per cell, which reveals an impressive level of flexibility. In this minireview, we summarize our contemporary understanding of meiotic recombination and its control mechanisms, and address the seemingly paradoxical and poorly understood diversity of recombination sites. Flexibility in the distribution of meiotic recombination events within genomes may reside in regulation at the chromatin level, with histone modifications playing a recently recognized role
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban BUDDING YEAST Cells Chromatin Chromosomes double-strand break DOUBLE-STRAND-BREAK Genome histone modification HOLLIDAY JUNCTION RESOLVASE HOT-SPOTS Infertility INITIATION SITES MEIOTIC GENE CONVERSION Molecular Biology Mutation PREMATURE OVARIAN FAILURE recombination review sister chromatid cohesion SISTER-CHROMATID COHESION Spo11 SYNAPTONEMAL COMPLEX-FORMATION YEAST SACCHAROMYCES-CEREVISIAE OTKA::1 MAB::3.1
Megjelenés:	The FEBS Journal. - 277 : 3 (2010), p. 571-589. -
További szerzők:	Nicolas, Alain
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus elérés DOI
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