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001-es BibID:	BIBFORM049067
035-os BibID:	PMID:9854019
Első szerző:	Szegedi Csaba
Cím:	Calsequestrin : more than 'only' a luminal Ca2+ buffer inside the sarcoplasmic reticulum / Csaba Szegedi, Sarkozi Sandor, Anke Herzog, Istvan Jóna, Magdolna Varsanyi
Dátum:	1999
ISSN:	0264-6021
Megjegyzések:	In striated muscle, the sarcoplasmic reticulum (SR) Ca2+ release/ryanodine receptor (RyR) channel provides the pathway through which stored Ca2+ is released into the myoplasm during excitation-contraction coupling. Various luminal Ca2+-binding proteins are responsible for maintaining the free [Ca2+] at 10(-3)-10(-4) M in the SR lumen; in skeletal-muscle SR, it is mainly calsequestrin. Here we show that, depending on its phosphorylation state, calsequestrin selectively controls the RyR channel activity at 1 mM free luminal [Ca2+]. Calsequestrin exclusively in the dephosphorylated state enhanced the open probability by approx. 5-fold with a Hill coefficient (h) of 3.3, and increased the mean open time by about 2-fold, i.e. solely dephosphorylated calsequestrin regulates Ca2+ release from the SR. Because calsequestrin has been found to occur mainly in the phosphorylated state in the skeletal-muscle SR for the regulation of RyR channel activity, the dephosphorylation of calsequestrin would appear to be a quintessential physiological event.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biochemical Journal. - 337 : Pt. 1 (1999), p. 19-22. -
További szerzők:	Sárközi Sándor (1966-) (élettanász) Herzog, Anke Jóna István (1948-) (élettanász, fizikus) Varsányi Magdolna
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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