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001-es BibID:	BIBFORM005185
035-os BibID:	(scopus)46449085498 (wos)000257176000003
Első szerző:	Kiss Endre (Budapest)
Cím:	Cytometry of raft and caveola membrane microdomains : from flow and imaging techniques to high throughput screening assays / Kiss, E., Nagy, P., Balogh, A., Szollosi, J., Matko, J.
Dátum:	2008
ISSN:	552-4930 (Electronic)
Megjegyzések:	The evolutionarily developed microdomain structure of biological membranes has gained more and more attention in the past decade. The caveolin-free "membrane rafts," the caveolin-expressing rafts (caveolae), as well as other membrane microdomains seem to play an essential role in controlling and coordinating cell-surface molecular recognition, internalization/endocytosis of the bound molecules or pathogenic organisms and in regulation of transmembrane signal transduction processes. Therefore, in many research fields (e.g. neurobiology and immunology), there is an ongoing need to understand the nature of these microdomains and to quantitatively characterize their lipid and protein composition under various physiological and pathological conditions. Flow and image cytometry offer many sophisticated and routine tools to study these questions. In this review, we give an overview of the past efforts to detect and characterize these membrane microdomains by the use of classical cytometric technologies, and finally we will discuss the results and perspectives of a new line of raft cytometry, the "high throughput screening assays of membrane microdomains," based on "lipidomic" and "proteomic" approaches.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Animals article Caveolae Cell Membrane chemistry Detergents Flow Cytometry Fluorescence Resonance Energy Transfer Humans Hungary Image Cytometry immunology Lipids Membrane Lipids Membrane Microdomains metabolism methods pharmacology Protein Structure, Tertiary Proteomics Research Research Support Signal Transduction Support
Megjelenés:	Cytometry. Part A. - 73A : 7 (2008), p. 599-614. -
További szerzők:	Nagy Péter (1971-) (biofizikus) Balogh Andrea Szöllősi János (1953-) (biofizikus) Matkó János (1952-) (biológus)
Internet cím:	DOI elektronikus változat
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