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001-es BibID:	BIBFORM077632
035-os BibID:	(cikkazonosító)1062 (scopus)85063627035 (wos)000462542300061
Első szerző:	Costea, Teodora
Cím:	Molecular Mechanisms and Bioavailability of Polyphenols in Prostate Cancer / Teodora Costea, Péter Nagy, Constanța Ganea, János Szöllősi, Maria-Magdalena Mocanu
Dátum:	2019
ISSN:	1661-6596 1422-0067
Megjegyzések:	: Prostate cancer is the one of the most frequently diagnosed cancers among men over the age of 50. Several lines of evidence support the observation that polyphenols have preventive and therapeutic effects in prostate cancer. Moreover, prostate cancer is ideal for chemoprevention due to its long latency. We propose here an equilibrated lifestyle with a diet rich in polyphenols as prophylactic attempts to slow down the progression of localized prostate cancer or prevent the occurrence of the disease. In this review, we will first summarize the molecular mechanisms of polyphenols in prostate cancer with a focus on the antioxidant and pro-oxidant effects, androgen receptors (AR), key molecules involved in AR signaling and their transactivation pathways, cell cycle, apoptosis, angiogenesis, metastasis, genetic aspects, and epigenetic mechanisms. The relevance of the molecular mechanisms is discussed in light of current bioavailability data regarding the activity of polyphenols in prostate cancer. We also highlight strategies for improving the bioavailability of polyphenols. We hope that this review will lead to further research regarding the bioavailability and the role of polyphenols in prostate cancer prevention and treatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban dietary polyphenols bioavailability molecular mechanisms prostate cancer
Megjelenés:	International Journal of Molecular Sciences. - 20 : 5 (2019), p. 1-39. -
További szerzők:	Nagy Péter (1971-) (biofizikus) Ganea, Constanta Szöllősi János (1953-) (biofizikus) Mocanu, Maria-Magdalena
Pályázati támogatás:	GINOP-2.3.2-15-2016-00020 GINOP GINOP-2.3.2-15-2016-00044 GINOP GINOP-2.3.3-15-2016-00003 GINOP K120302 Egyéb
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001-es BibID:	BIBFORM074167
Első szerző:	Filippi, Alexandru
Cím:	Epigallocatechin-3-gallate alleviates the malignant phenotype in A-431 epidermoid and SK-BR-3 breast cancer cell lines / Filippi Alexandru, Picot Tiphanie, Aanei Carmen Mariana, Nagy Péter, Szöllősi János, Campos Lydia, Ganea Constanţa, Mocanu Maria-Magdalena
Dátum:	2018
ISSN:	0963-7486
Megjegyzések:	In this study, we evaluated the effects of epigallocatechin-3-O-gallate (EGCG) in two cancer cell lines, A-431 overexpressing ErbB1 and SK-BR-3, overexpressing ErbB2. EGCG treatment showed dose-dependent collapse of mitochondrial membrane potential (??m), increase in reactive oxygen species (ROS) production, changes in nuclear morphology and reduced viability. Flow cytometry data indicated that EGCG partially decreases the phosphorylation of several proteins involved in cell proliferation and survival: pErbB1(Y1173, Y1068), pAkt(S473) and pERK(Y204). EGCG affected the clonogenic growth in both cell lines with an EC50 of 2.5 and 5.4??M for A-431 and SK-BR-3, respectively. Wound scratch assay demonstrated that EGCG inhibited the healing in dose-dependent manner and the effect was correlated with partial reduction in phosphorylation of pFAK(S910). Our data suggest that EGCG administration might reduce the unfavourable traits, particularly associated with ErbB1/EGFR overexpression.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	International Journal Of Food Sciences And Nutrition. - 69 : 5 (2018), p. 584-597. -
További szerzők:	Picot, Tiphanie Aanei, Carmen Mariana Nagy Péter (1971-) (biofizikus) Szöllősi János (1953-) (biofizikus) Campos, Lydia Ganea, Constanta Mocanu, Maria-Magdalena
Pályázati támogatás:	K120302 OTKA K103906 OTKA GINOP-2.3.2-15-2016-00020 GINOP GINOP-2.3.2-15-2016-00050 GINOP
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001-es BibID:	BIBFORM057539
035-os BibID:	(scopus)84896847673 (wos)000332354700009
Első szerző:	Mocanu, Maria-Magdalena
Cím:	Epigallocatechin 3-O-gallate induces 67 kDa laminin receptor-mediated cell death accompanied by downregulation of ErbB proteins and altered lipid raft clustering in mammary and epidermoid carcinoma cells / Maria-Magdalena Mocanu, Constanta Ganea, Laura Georgescu, Tímea Váradi, Dilip Shrestha, Irina Baran, Eva Katona, Peter Nagy, János Szöllősi
Dátum:	2014
ISSN:	0163-3864
Megjegyzések:	Since the administration of synthetic medicines is associated with drug resistance and undesired side effects, utilization of natural compounds could be an alternative and complementary modality to inhibit or prevent the development of tumors. Epigallocatechin 3-O-gallate (EGCG, 1), the major flavan component of green tea, and genistein (2), a soy isoflavonoid, are known to have chemopreventive and chemotherapeutic effects against cancer. This study demonstrated that both flavonoids inhibit cell proliferation, an effect enhanced under serum-free conditions. Compound 1, but not 2, induced downregulation of ErbB1 and ErbB2 in mammary and epidermoid carcinoma cells, and its inhibitory effect on cell viability was mediated by the 67 kDa laminin receptor (67LR). While 1 was superior in inducing cell death, 2 was more efficient in arresting the tumor cells in the G2/M phase. Furthermore, number and brightness analysis revealed that 1 decreased the homoclustering of a lipid raft marker, glycosylphosphatidylinositol-anchored GFP, and it also reduced the co-localization between lipid rafts and 67LR. The main conclusion made is that the primary target of 1 may be the lipid raft component of the plasma membrane followed by secondary changes in the expression of ErbB proteins. Compound 2, on the other hand, must have other unidentified targets.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Epigallocatechin Molekuláris Medicina
Megjelenés:	Journal Of Natural Products. - 77 : 2 (2014), p. 250-257. -
További szerzők:	Ganea, Constanta Georgescu, Laura Váradi Tímea (1982-) (okleveles vegyész) Shrestha, Dilip (1980-) (biológus) Baran, Irina Katona Éva (1961-) (klinikai biokémikus) Nagy Péter (1971-) (biofizikus) Szöllősi János (1953-) (biofizikus)
Pályázati támogatás:	TÁMOP-4.2.2-08/1-2008-0019 TÁMOP TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Receptor tirozin kinázok mint terápiás célpontok: működésük szabályozásának, és a közöttük fellépő molekuláris kölcsönhatások vizsgálata
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