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001-es BibID:	BIBFORM005174
035-os BibID:	(scopus)38349044364 (wos)000253278400023
Első szerző:	Barok Márk (biofizikus)
Cím:	Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumor / Márk Barok, Margit Balázs, Péter Nagy, Zsuzsa Rákosy, Andrea Treszl, Enikő Tóth, István Juhász, John W. Park, Jorma Isola, György Vereb, János Szöllősi
Dátum:	2008
ISSN:	304-3835 (Print)
Megjegyzések:	We have recently shown that despite of the fact that the ErbB2-positive JIMT-1 human breast cancer cells intrinsically resistant to trastuzumab in vitro, trastuzumab inhibited the outgrowth of early phase JIMT-1 xenografts in SCID mice via antibody-dependent cellular cytotoxicity (ADCC). Here we show that trastuzumab significantly reduces the number of circulating and disseminated tumor cells (CTCs and DTCs) in this xenograft model system at a time when the primary tumor is already unresponsive to trastuzumab. This observation suggests that ErbB2 positive CTCs and DTCs might be sensitive to trastuzumab-mediated ADCC even if when the primary tumor is already non-responsive. Thus, trastuzumab treatment might also be beneficial in the case of patients with breast cancer that is already trastuzumab resistant.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk analysis Animals antagonists and inhibitors Antibodies Antibodies, Monoclonal Antigens Antigens, CD45 Antineoplastic Agents article Biophysics blood Bone Marrow Breast Neoplasms Cell Line, Tumor Cells Chromosomes, Human,X drug effects Drug Resistance, Neoplasm drug therapy EGFR Epidermal Growth Factor ErbB2 Female genetics Histocompatibility Antigens Histocompatibility Antigens Class I Human Humans Hungary Immunohistochemistry immunology In Situ Hybridization,Fluorescence In Vitro metabolism Mice Mice, Scid mouse Neoplasm Circulating Cells Neoplasm Metastasis pathology pharmacology Receptor, Epidermal Growth Factor Research Research Support Support therapeutic use Time Factors Trastuzumab resistance Xenograft Model Antitumor Assays egyetemen (Magyarországon) készült közlemény
Megjelenés:	Cancer Letters. - 260 : 1-2 (2008), p. 198-208. -
További szerzők:	Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Nagy Péter (1971-) (biofizikus) Rákosy Zsuzsa (1978-) (sejtbiológus, molekuláris biológus, genetikus) Treszl Andrea (1974-) (molekuláris biológus) Tóth Enikő Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus) Park, John W. Isola, Jorma Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus)
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001-es BibID:	BIBFORM004634
035-os BibID:	(scopus)0032101894 (wos)000073937700007
Első szerző:	Nagy Péter (biofizikus)
Cím:	EGF-induced redistribution of erbB2 on breast tumor cells : flow and image cytometric energy transfer measurements / Nagy, P., Bene, L., Balazs, M., Hyun, W. C., Lockett, S. J., Chiang, N. Y., Waldman, F., Feuerstein, B. G., Damjanovich, S., Szollosi, J.
Dátum:	1998
Megjegyzések:	erbB2, a member of the epidermal growth factor (EGF) receptor-type tyrosine kinase receptor family, is overexpressed in breast carcinomas with poor prognosis. We examined the cell surface association of this receptor with itself and with other cell surface proteins by the Forster-type fluorescence resonance energy transfer using whole antibodies and Fab fragments. We found that erbB2 molecules homoassociate in unstimulated SK-BR-3, BT474 and BT474-M (a metastatic version of the parent BT474 line) breast tumor cells, and that the interaction was enhanced by EGF treatment in suspensions of SK-BR-3 and BT474-M cells. BT474 cells (with low EGF receptor expression) and attached SK-BR-3 cells do not respond to EGF. Image microscopic energy transfer measurements found considerable pixel-by-pixel heterogeneity in the homoassociation state of erbB2. In accordance with the EGF-induced redistribution of erbB2, EGF receptor was found to be in close proximity to erbB2 in FRET measurements. By labeling different epitopes on erbB2 and the lipid bilayer, we were able to prepare an epitope map of erbB2 molecule. Our data suggest the existence of dynamic cell surface patterns of erbB2 and point to functions fulfilled by these molecular complexes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk analysis biosynthesis Breast Neoplasms Carcinoma Cell Membrane chemistry drug effects Energy Transfer Epidermal Growth Factor Female Flow Cytometry Fluorescence Human Hungary metabolism methods Models Molecular pharmacology Receptor erbB-2 Receptors Transferrin Support Non-U.S.Gov't Tumor Cells,Cultured Squamous Cell ultrastructure
Megjelenés:	Cytometry. - 32 : 2 (1998), p. 120-131. -
További szerzők:	Bene László (1963-) (biofizikus) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Hyun, William C. Lockett, Steven J. Chiang, Nancy Y. Waldman, Frederick Feuerstein, Burt G. Damjanovich Sándor (1936-2017) (biofizikus) Szöllősi János (1953-) (biofizikus)
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