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001-es BibID:	BIBFORM103531
035-os BibID:	(cikkazonosító)1176 (WoS)000856169800001 (Scopus)85138543871
Első szerző:	Mazzone, Flaminia
Cím:	In Vitro Biological Activity of Natural Products from the Endophytic Fungus Paraboeremia selaginellae against Toxoplasma gondii / Flaminia Mazzone, Viktor E. Simons, Lasse van Geelen, Marian Frank, Attila Mándi, Tibor Kurtán, Klaus Pfeffer, Rainer Kalscheuer
Dátum:	2022
ISSN:	2079-6382
Megjegyzések:	Toxoplasma gondii is an apicomplexan pathogen able to infect a wide range of warm-blooded animals, including humans, leading to toxoplasmosis. Current treatments for toxoplasmosis are associated with severe side-effects and a lack efficacy to eradicate chronic infection. Thus, there is an urgent need for developing novel, highly efficient agents against toxoplasmosis with low toxicity. For decades, natural products have been a useful source of novel bioactive compounds for the treatment of infectious pathogens. In the present study, we isolated eight natural products from the crude extract of the endophytic fungus Paraboeremia selaginellae obtained from the leaves of the plant Philodendron monstera. The natural products were tested for inhibiting Toxoplasma gondii proliferation, and their cytotoxicity was evaluated in different human cell lines. Six natural products showed antitoxoplasma activity with low or no cytotoxicity in human cell lines. Together, these findings indicate that biphenyl ethers, bioxanthracenes, and 5S,6S-phomalactone from P. selaginellae are potential candidates for novel anti-toxoplasma drugs.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Toxoplasma gondii Paraboeremia selaginellae endophytic fungi natural products bioactivity biphenyl ether bioxanthracene phomalactone
Megjelenés:	Antibiotics-Basel. - 11 : 9 (2022), p. 1-15. -
További szerzők:	Simons, Viktor Emanuel van Geelen, Lasse Frank, Marian Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Pfeffer, Klaus Kalscheuer, Rainer
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114545
035-os BibID:	(cikkazonosító)1273 (WoS)001056494500001 (Scopus)85169073697
Első szerző:	Wennrich, Jan-Pee
Cím:	Bioactive Naphtho-alpha-Pyranones from Two Endophytic Fungi of the Genus Polyphilus / Jan-Peer Wennrich, Ellen Sepanian, Sherif S. Ebada, Natalia A. Llanos-Lopez, Samad Ashrafi, Wolfgang Maier, Tibor Kurtán, Marc Stadler
Dátum:	2023
ISSN:	2079-6382
Megjegyzések:	In the course of our survey to study the metabolic potential of two species of a new helotialean genus Polyphilus, namely P. frankenii and P. sieberi, their crude extracts were obtained using different cultivation techniques, which led to the isolation and characterization of two new naphthoa-pyranone derivatives recognized as a monomer (1) and its 6,6 '-homodimer (2) together with two known diketopiperazine congeners, outovirin B (3) and (3S,6S)-3,6-dibenzylpiperazine-2,5-dione (4). The structures of isolated compoundswere determined based on extensive 1D and 2DNMR andHRESIMS. The absolute configuration of new naphtho- a-pyranones was determined using a comparison of their experimental ECD spectra with those of related structural analogues. 6,6 ' -binaphtho- alpha-pyranone talaroderxine C (2) exhibited potent cytotoxic activity against different mammalian cell lines with IC50 values in the low micromolar to nanomolar range. In addition, talaroderxine C unveiled stronger antimicrobial activity against Bacillus subtilis rather than Staphylococcus aureus with MIC values of 0.52 mu g mL (-1) (0.83 mu M) compared to 66.6 mu g mL 1 (105.70 mu M), respectively.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Polyphilus Helotiales Ascomycota naphthopyranones antimicrobial
Megjelenés:	Antibiotics-Basel. - 12 : 8 (2023), p. 1-9. -
További szerzők:	Sepanian, Ellen Ebada, Sherif Saeed Llanos-López, Natalia A. Ashrafi, Samad Maier, Wolfgang Kurtán Tibor (1973-) (vegyész, angol szakfordító) Stadler, Marc
Pályázati támogatás:	K-138672 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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