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001-es BibID:	BIBFORM061786
Cím:	Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp. / Ren-Yong Huang, Wen-Ting Chen, Tibor Kurtán, Attila Mándi, Jian Ding, Jia Li, Xu-Wen Li, Yue-Wei Guo
Dátum:	2016
ISSN:	1756-8919 1756-8927
Megjegyzések:	Background: Nudibranchs are slug-like invertebrates, well known as rich sources of biologically active secondary metabolites with highly chemical diversity and complexity. The production of such interesting metabolites was possibly inflenced by their diet relationship with sponges such as Xestospongia. Results: Our continuous investigation of South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp. led to the isolation of two new and eight known metabolites (1-10). The absolute confiurations were determined by time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) method and by the comparison of ECD spectra. In bioassays, 1-4 and 7 showed strong NF-?B inhibitory activity, 4-6 exhibited considerable cytotoxicity against A549 and HL-60 tumor cell lines. Conclusion: Five unusual isoquinolinequinones (3, 7-10) were discovered from both two animals, further confimed their predator-prey relationship. Preliminary bioassay results and structure-activity relationship studies suggested that several isolated compounds were potential to be drug leads.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban epimer NF-[kappa]B signaling pathway TDDFT ECD tetrahydroisoquinolinequinone
Megjelenés:	Future Medicinal Chemistry. - 8 : 1 (2016), p. 17-27. -
További szerzők:	Huang, Ren-Yong Chen, Wen-Ting Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Ding, Jian Li, Jia Li, Xu-Wen Guo, Yue-Wei
Pályázati támogatás:	K105871 OTKA NIIFI 10038 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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