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001-es BibID:	BIBFORM065737
Első szerző:	Liu, Yang
Cím:	Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides / Yang Liu, Tibor Kurtán, Chang Yun Wang, Wen Han Lin, Raha Orfali, Werner E. G. Müller, Georgios Daletos, Peter Proksch
Dátum:	2016
ISSN:	0021-8820
Megjegyzések:	A new cytotoxic viriditoxin derivative, cladosporinone (1), along with the known viriditoxin (2) and two viriditoxin derivatives (3 and 4) were obtained from the fungus Cladosporium cladosporioides isolated from the sediment of a hypersaline lake in Egypt. The structure of the new compound (1) was determined by 1D and 2D NMR measurements as well as by high-resolution ESIMS and electronic circular dichroism spectroscopy. All isolated compounds were studied for their cytotoxicity against the murine lymphoma cell line L5187Y and for their antibiotic activity against several pathogenic bacteria. Viriditoxin (2) was the most active compound in both bioassays. Compound 1 also exhibited strong cytotoxicity against the murine lymphoma cell line L5187Y with an IC50 value of 0.88 ?M, whereas its antibiotic activity was weak.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Antibiotics 69 : 9 (2016), p. 702-706. -
További szerzők:	Kurtán Tibor (1973-) (vegyész, angol szakfordító) Yun Wang, Chang Han Lin, Wen Orfali, Raha Müller, Werner E. G. Daletos, Georgios Proksch, Peter
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