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001-es BibID:	BIBFORM016873
Első szerző:	Cai, You-Sheng
Cím:	Palmarumycins BG1-BG7 and Preussomerin BG1 : Establishment of Their Absolute Configurations Using Theoretical Calculations of Electronic Circular Dichroism Spectra / You-Sheng Cai, Tibor Kurtán, Ze-Hong Miao, Attila Mándi, István Komáromi, Hai-Li Liu, Jian Ding, Yue-Wei Guo
Dátum:	2011
Megjegyzések:	Palmarumycins BG1-BG7 (1-7), seven new compounds related to palmarumycins, were isolated from the aerial parts of Bruguiera gymnorrhiza as well as a new preussomerin derivative BG1 (8). The structures of these compounds were determined mainly by the analysis of their NMR and MS data, and their relative configurations were assigned on the basis of their 3JH,H coupling constants. Compounds 4 and 7 have a sulfate group that is unprecedented amongmembers of spirodioxynaphthalene-type natural products. The absolute configurations of 1-8 were determined by TDDFT CD calculations of the solution conformers. Compound 5 displayed inhibitory activity against HL 60 and MCF-7 cell lines.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Organic Chemistry. - 76 : 6 (2011), p. 1821-1830. -
További szerzők:	Kurtán Tibor (1973-) (vegyész, angol szakfordító) Miao, Ze-Hong Mándi Attila (1981-) (vegyész, német szakfordító) Komáromi István (1957-) (vegyész, molekuláris biológus, biokémikus) Liu, Hai-Li Ding, Jian Guo, Yue-Wei
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM024617
Első szerző:	Wang, Jian-Rong
Cím:	Protolimonoids and norlimonoids from the stem bark of Toona ciliata var. pubescens / Jian-Rong Wang, Hai-Li Liu, Tibor Kurtán, Attila Mándi, Sándor Antus, Jia Li, Hai-Yan Zhanga, Yue-Wei Guo
Dátum:	2011
ISSN:	1477-0520
Megjegyzések:	Six new tirucallane protolimonoids, toonapubesins A-F (1-6), one new rearranged tirucallane protolimonoid, toonapubesin G (7), and two new 21,22,23-trinorapotirucallane limonoids, toonapubesic acids A (8) and B (9), possessing an unprecedented carbon skeleton, along with five known tirucallane protolimonoids (10?14) and one known apotirucallane limonoid (15), were isolated from the stem bark of Toona ciliata var. pubescens. Their structures and relative configurations were determined by detailed spectroscopic analysis and by chemical methods. The proposed structures of 8 and 11 were confirmed by X-ray diffraction analysis of their respective derivatives (8a and 11a). The absolute configuration of 8 was determined by a novel solid-state TDDFT ECD approach on its derivative 8a while the absolute configuration of 10 was determined by the modified Mosher's method. In addition, the structures of dyvariabilin H (10c) proposed by Sticher et al. and cneorin-NP36 (11b) by Mondon et al. were corrected as 10 and 11, respectively. Toonapubesin G (7) showed promising inhibitory activity against CDC25B with an IC50 value of 2.1 mM, while compound 8a showed significant cell protecting activity against H2O2-induced SH-SY5Y cell damage with 11.5% increase in cell viability.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Organic & Biomolecular Chemistry. - 9 : 22 (2011), p. 7685-7696. -
További szerzők:	Liu, Hai-Li Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Antus Sándor (1944-2022) (vegyészmérnök) Li, Jia Zhang, Hai-Yan Guo, Yue-Wei
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM054937
Első szerző:	Zhou, Zhen-Fang
Cím:	Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum / Zhen-Fang Zhou, Ling-Yi Kong, Tibor Kurtán, Hai-Li Liu, Attila Mándi, Jia Li, Yu-Cheng Gu, Yue-Wei Guo
Dátum:	2014
ISSN:	0032-0943
Megjegyzések:	Four new 8,9,30-phragmalin orthoesters (1-4), along with six related known compounds, namely xyloccensins O-S (5-9) and V (10), were isolated and characterized from the twigs and leaves of the Chinese mangrove Xylocarpus granatum. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and by comparison with those of related known compounds in the literature. The absolute configuration of xyloccensin Q (7) was revised as its enantiomer by X?ray diffraction analysis employing graphite monochromated Cu K?radiation (? = 1.54 178 A) with a Flack parameter of ?0.04 and was further secured by a time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. Consequently, the absolute configurations of xyloccensins O (5), P (6), R (8), S (9), and V (10) were all corrected as their corresponding enantiomers, respectively. Xyloccensin S (9) exhibited inhibitory activity against protein tyrosine phosphatase 1B, a potential drug target for the treatment of type II diabetes and obesity, with an IC50 value of 8.72 ?g/mL.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Meliaceae Xylocarpus granatum phragmalin orthoesters configuration determination biological activity
Megjelenés:	Planta Medica. - 80 : 11 (2014), p. 949-954. -
További szerzők:	Kong, Ling-Yi Kurtán Tibor (1973-) (vegyész, angol szakfordító) Liu, Hai-Li Mándi Attila (1981-) (vegyész, német szakfordító) Li, Jia Gu, Yu-Cheng Guo, Yue-Wei
Pályázati támogatás:	K105871, K81701 OTKA NIIFI 10038 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM054600
Első szerző:	Zhou, Zhen-Fang
Cím:	Bioactive rearranged limonoids from the Chinese mangrove Xylocarpus granatum Koenig / Zhen-Fang Zhou, Hai-Li Liu, Wen Zhang, Tibor Kurtan, Attila Mandi, Attila Benyei, Jia Li, Orazio Taglialatela-Scafati, Yue-Wei Guo
Dátum:	2014
ISSN:	0040-4020
Megjegyzések:	Xylocarpus granatum Limonoid ECD calculation PTP1B inhibition Two new pyridine-containing limonoids, xylogranatopyridines A and B (1 and 2) and their formal precursor, prexylogranatopyridine (3) were isolated from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum. Xylogranatopyridine B (2) possesses an unprecedented rearranged B-ring together with a seco-ring A, supporting the biogenetic connection of 1?2 with 3. The chemical structures were elucidated by means of detailed spectroscopic analysis and X-ray single-crystal diffraction. The absolute configurations were assigned using electronic solid-state circular dichroism (ECD) supported by timedependent density functional theory (TDDFT) ECD calculations and X-ray analysis. Xylogranatopyridine A (1) exhibited a significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 22.9 mM. This is thefirst report of PTP1B inhibitory activity of limonoids.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Xylocarpus granatum Limonoid ECD calculation PTP1B inhibition
Megjelenés:	Tetrahedron. - 70 : 37 (2014), p. 6444-6449. -
További szerzők:	Liu, Hai-Li Zhang, Wen Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Bényei Attila (1962-) (vegyész) Li, Jia Taglialatela-Scafati, Orazio Guo, Yue-Wei
Pályázati támogatás:	K105871, K81701 OTKA NIIFI 10038 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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