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1.

001-es BibID:BIBFORM078385
Első szerző:Abdel-Wahab, Nada
Cím:Induction of Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor through Co-cultivation with Bacillus subtilis / Nada M. Abdel-Wahab, Sebastian Scharf, Ferhat C. Özkaya, Tibor Kurtán, Attila Mándi, Mostafa A. Fouad, Mohamed S. Kamel, Werner E. G. Müller, Rainer Kalscheuer, Wenhan Lin, Georgios Daletos, Weaam Ebrahim, Zhen Liu, Peter Proksch
Dátum:2019
ISSN:0032-0943
Megjegyzések:A new cyclic pentapeptide, cotteslosin C (1), a new aflaquinolone, 22-epi-aflaquinolone B (3), and two new anthraquinones (9 and 10), along with thirty known compounds (2, 4???8, 11???34) were isolated from a co-culture of the sponge-associated fungus Aspergillus versicolor with Bacillus subtilis. The new metabolites were only detected in the co-culture extract, but not when the fungus was grown under axenic conditions. Furthermore, the co-culture extract exhibited an enhanced accumulation of the known constituents versicolorin B (14), averufin (16), and sterigmatocyctin (19) by factors of 1.5, 2.0, and 4.7, respectively, compared to the axenic fungal culture. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR spectra and mass spectrometry as well as by comparison with literature data. The absolute configuration of compounds 3, 9, and 10 was determined by ECD (electronic circular dichroism) analysis aided by TDDFT-ECD (time-dependent density functional theory electronic circular dichroism) calculations. Compounds 15, 18???21, and 26 exhibited strong to moderate cytotoxic activity against the mouse lymphoma cell line L5178Y, with IC50 values ranging from 2.0 to 21.2??M, while compounds 14, 16, 31, 32, and 33 displayed moderate inhibitory activities against several gram-positive bacteria, with MIC values ranging from 12.5 to 50??M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
sponge-derived fungus
Aspergillus versicolor
cyclic pentapeptide
co-culture
ECD calculations
cytotoxicity
antibacterial activity
Megjelenés:Planta Medica. - 85 : 06 (2019), p. 503-512. -
További szerzők:Scharf, Sebastian Özkaya, Ferhat Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Fouad, Mostafa A. Kamel, Mohamed S. Müller, Werner E. G. Kalscheuer, Rainer Lin, Wen Han Daletos, Georgios Ebrahim, Weaam Liu, Zhen Proksch, Peter
Pályázati támogatás:K120181
OTKA
PD121020
OTKA
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2.

001-es BibID:BIBFORM065735
035-os BibID:(Scopus)84987948925
Első szerző:Akone, Sergi Herve
Cím:Inducing secondary metabolite production by the endophytic fungus Chaetomium sp. through fungal-bacterial co-culture and epigenetic modification / Sergi Herve Akone, Attila Mandi, Tibor Kurtan, Rudolf Hartmann, Wenhan Lin, Georgios Daletos, Peter Proksch
Dátum:2016
ISSN:0040-4020
Megjegyzések:Co-culturing the fungal endophyte Chaetomium sp. with the bacterium Bacillus subtilis on solid rice medium resulted in an up to 8.3-fold increase in the accumulation of constitutively present metabolites that included a 1:1 mixture of 3- and 4-hydroxybenzoic acid methyl esters (1 and 2, respectively), and the polyketides acremonisol A (3), SB236050 (4), and SB238569 (5). In addition, seven compounds including isosulochrin (6), protocatechuic acid methyl ester (7), as well as five new natural products (8?12) were detected in the co-cultures, but not in axenic fungal cultures. Treatment of Chaetomium sp. with the epigenetic modifier suberoylanilide hydroxamic acid or 5-azacytidine resulted in an enhanced accumulation of 6, which was likewise detected during co-culture. Compound 5 showed strong cytotoxicity against the mouse lymphoma L5178Y cell line with an IC50 value of 1 mM, as well as weak antibacterial activity against B. subtilis with an MIC value of 53 mM.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Co-cultivation
Chaetomium sp.
Bacillus subtilis
Epigenetic modifiers
Natural products
Megjelenés:Tetrahedron 72 : 41 (2016), p. 6340-6347. -
További szerzők:Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Hartmann, Rudolf Lin, Wen Han Daletos, Georgios Proksch, Peter
Pályázati támogatás:K105871
OTKA
NIIFI 10038
Egyéb
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3.

001-es BibID:BIBFORM069609
Első szerző:Ancheeva, Elena
Cím:Expanding the Metabolic Profile of the Fungus Chaetomium sp. through Co-culture with Autoclaved Pseudomonas aeruginosa / Elena Ancheeva, Lisa Küppers, Sergi Herve Akone, Weaam Ebrahim, Zhen Liu, Attila Mándi, Tibor Kurtán, Wenhan Lin, Raha Orfali, Nidja Rehberg, Rainer Kalscheuer, Georgios Daletos, Peter Proksch
Dátum:2017
ISSN:1434-193X 1099-0690
Megjegyzések:The mixed fermentation of the fungal endophyte Chaetomium sp. with an autoclaved culture of the bacterium Pseudomonas aeruginosa on solid rice medium led to an up to 33-fold increase in the accumulation of constitutively present fungal secondary metabolites (3-10), which included four new butenolide derivatives (3-5 and 7). In addition, two further shikimic acid analogues (1 and 2) were obtained from mixed cultures that were neither detected in axenic cultures of the fungus nor of the bacterium. Chaetoisochorismin (1 ) possesses an unusual (3-methoxycarbonylphenyl)pyruvate core structure. The structures of the new compounds were unequivocally elucidated by HRESIMS, one- and two-dimensional NMR analysis as well as by comparison with literature data. The absolute configurations of the structures of the new derivatives 1 and 2 were established by ECD calculations as well as by the modified Mosher's method. Compounds 1-3 and 5-7 were subjected to antimicrobial and cytotoxicity assays but were shown to be inactive.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Chaetomium sp.
Autoclaved Pseudomonas aeruginosa
Shikimic acid derivatives
Structure elucidation
TDDFT-ECD calculations
Biosynthesis
Megjelenés:European Journal of Organic Chemistry 22 (2017), p. 3256-3264. -
További szerzők:Küppers, Lisa Akone, Sergi Herve Ebrahim, Weaam Liu, Zhen Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Lin, Wen Han Orfali, Raha Rehberg, Nidja Kalscheuer, Rainer Daletos, Georgios Proksch, Peter
Pályázati támogatás:NKFI K120181
Egyéb
NKFI PD121020
Egyéb
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4.

001-es BibID:BIBFORM080474
Első szerző:Ariantari, Ni P.
Cím:Expanding the chemical diversity of an endophytic fungus Bulgaria inquinans, an ascomycete associated with mistletoe, through an OSMAC approach / Ni P. Ariantari, Georgios Daletos, Attila Mándi, Tibor Kurtán, Werner E. G. Müller, Wenhan Lin, Elena Ancheeva, Peter Proksch
Dátum:2019
ISSN:2046-2069 2046-2069
Megjegyzések:An endophytic fungus Bulgaria inquinans (isolate MSp3-1), isolated from mistletoe (Viscum album), was subjected to fermentation on solid Czapek medium. Chromatographic workup of the crude EtOAc extract yielded five new natural products (1?5). Subsequent application of the "One Strain, Many Compounds" (OSMAC) strategy on this strain by the addition of a mixture of salts (MgSO4, NaNO3 and NaCl) to solid Czapek medium induced the accumulation of nine additional new secondary metabolites (6?13, 16), with most of them (8, 10?12) not detectable in cultures lacking the salt mixture. The structures of the new compounds were established on the basis of the 1D/2D NMR and HRESIMS data. The TDDFT-ECD method was applied to determine the absolute configurations of the new compounds 1, 4 and 6 as well as of the previously reported bulgarialactone B (14), for which the absolute configuration was unknown so far. The modified Mosher's method was performed to assign the absolute configurations of 12 and 13. TDDFT-ECD analysis also allowed determining the absolute configuration of (+)-epicocconone, which had an enantiomeric absolute configuration in the tricyclic moiety compared to that of bulgarialactone B (14). All the isolated metabolites were evaluated for their cytotoxic activity. Compound 2 was found to possess strong cytotoxic activity against the murine lymphoma cell line L5178Y with an IC50 value of 1.8 mM, while the remaining metabolites were shown to be inactive.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:RSC Advances. - 9 : 43 (2019), p. 25119-25132. -
További szerzők:Daletos, Georgios Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Müller, Werner E. G. Lin, Wen Han Ancheeva, Elena Proksch, Peter
Pályázati támogatás:NKFI K120181
Egyéb
NKFI PD121020
Egyéb
GINOP-2.3.2-15-2016-00008
GINOP
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5.

001-es BibID:BIBFORM044503
Első szerző:Bara, Robert
Cím:Atropisomeric Dihydroanthracenones as Inhibitors of Multiresistant Staphylococcus aureus / Robert Bara, Ilka Zerfass, Amal H. Aly, Heike Goldbach-Gecke, Vijay Raghavan, Peter Sass, Attila Mándi, Victor Wray, Prasad L. Polavarapu, Alexander Pretsch, WenHan Lin, Tibor Kurtán, Abdessamad Debbab, Heike Brötz-Oesterhelt, Peter Proksch
Dátum:2013
ISSN:0022-2623 1520-4804
Megjegyzések:Two bisdihydroanthracenone atropodiastereomeric pairs, including homodimeric flavomannin A (1) and the previously unreported flavomannin B (2), two new unsymmetrical dimers (3 and 4), and two new mixed dihydroanthracenone/anthraquinone dimers (5 and 6) were isolated from Talaromyces wortmannii, an endophyte of Aloe vera. The structures of 2?6 were elucidated by extensive NMR and mass spectrometric analyses. The axial chirality of the biaryls was determined using TDDFT ECD and VCD calculations, the combination of which however did not allow the assignment of the central chirality elements of 1. The compounds exhibited antibacterial activity against Staphylococcus aureus, including (multi)drug-resistant clinical isolates. Reporter gene analyses indicated induction of the SOS response for some of the derivatives, suggesting interference with DNA structure or metabolism. Fluorescence microscopy demonstrated defective segregation of the bacterial chromosome and DNA degradation. Notably, the compounds showed no cytotoxic activity, encouraging their further evaluation as potential starting points for antibacterial drug development.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Medicinal Chemistry. - 56 : 8 (2013), p. 3257-3272. -
További szerzők:Zerfass, Ilka Aly, Amal H. Goldbach-Gecke, Heike Raghavan, Vijay Sass, Peter Mándi Attila (1981-) (vegyész, német szakfordító) Wray, Victor Polavarapu, Prasad L. Pretsch, Alexander Lin, Wen Han Kurtán Tibor (1973-) (vegyész, angol szakfordító) Debbab, Abdessamad Brötz-Oesterhelt, Heike Proksch, Peter
Pályázati támogatás:K105871
OTKA
NIIFI 10038
Egyéb
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6.

001-es BibID:BIBFORM060293
Első szerző:Chen, Huiqin
Cím:A new fusarielin analogue from Penicillium sp. isolated from the Mediterranean sponge Ircinia oros / Huiqin Chen, Nihal Aktas, Belma Konuklugil, Attila Mándi, Georgios Daletos, Wenhan Lin, Haofu Dai, Tibor Kurtán, Peter Proksch
Dátum:2015
ISSN:0040-4039
Megjegyzések:The marine-derived fungus Penicillium sp. (strain IO1) isolated from the Mediterranean sponge Ircinia oros yielded a new fusarielin analogue (1) together with the known compounds griseofulvin (4) and dechlorogriseofulvin (5). The structure of 1 was unambiguously elucidated by comprehensive spectroscopic analysis (1D and 2D NMR, and mass spectrometry) as well as by comparison with the literature, while the absolute configuration of 1 was determined on the basis of TDDFT ECD calculations. A further Penicillium sp. (strain IO2) that was isolated from the same sponge I. oros yielded the known compounds dehydrocurvularin (6), curvularin (7), and trichodimerol (8). Co-cultivation of both Penicillium strains (IO1 and IO2) was found to induce the accumulation of the known norlichexanthone (2) and monocerin (3) that were not detected in either of the two axenic fungal controls. Compounds 3 and 6 showed pronounced cytotoxicity against the murine lymphoma (L5178Y) cell line with IC50 values of 8.4 and 4.7 lM, respectively.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Penicillium sp.
Absolute configuration
Co-cultivation
Cytotoxicity
Sponge-derived fungus
Megjelenés:Tetrahedron Letters. - 56 : 39 (2015), p. 5317-5320. -
További szerzők:Aktas, Nihal Konuklugil, Belma Mándi Attila (1981-) (vegyész, német szakfordító) Daletos, Georgios Lin, Wen Han Dai, Haofu Kurtán Tibor (1973-) (vegyész, angol szakfordító) Proksch, Peter
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7.

001-es BibID:BIBFORM043665
Első szerző:Ebrahim, Weaam
Cím:Embellicines A and B: Absolute Configuration and NF-kB Transcriptional Inhibitory Activity / Weaam Ebrahim, Amal H. Aly, Victor Wray, Attila Mándi, Marie-Hélène Teiten, François Gaascht, Barbora Orlikova, Matthias U. Kassack, WenHan Lin, Marc Diederich, Tibor Kurtán, Abdessamad Debbab, Peter Proksch
Dátum:2013
ISSN:0022-2623 1520-4804
Megjegyzések:Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and twodimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configuration of embellicine A (1) was determined by TDDFT ECD calculations of solution conformers, whereas that of embellicine B (2) was deduced based on ROESY correlations and on biogenetic considerations in comparison to 1. Both embellicines (1 and 2) are cytostatic, cytotoxic, and inhibit NF-?B transcriptional activity, indicating that inhibition of NF-?B may be a possible mechanism of action of these compounds. Embellicine B (2) was the most active compound encountered in this study and acts at nanomolar concentrations without affecting tumor microenvironment.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Medicinal Chemistry. - 56 : 7 (2013), p. 2991-2999. -
További szerzők:Aly, Amal H. Wray, Victor Mándi Attila (1981-) (vegyész, német szakfordító) Teiten, Marie-Hélène Gaascht, François Orlikova, Barbora Kassack, Matthias Lin, Wen Han Diederich, Marc Kurtán Tibor (1973-) (vegyész, angol szakfordító) Debbab, Abdessamad Proksch, Peter
Pályázati támogatás:HURO/0901/274/2.2.2
Egyéb
NIIFI 10038
Egyéb
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8.

001-es BibID:BIBFORM043030
Első szerző:Ebrahim, Weaam
Cím:O-Heterocyclic Embeurekols from Embellisia eureka, an Endophyte of Cladanthus arabicus / Weaam Ebrahim, Amal H. Aly, Attila Mándi, Victor Wray, El Mokhtar Essassi, Tarik Ouchbani, Rachid Bouhfid, Wenhan Lin, Peter Proksch, Tibor Kurtán, Abdessamad Debbab
Dátum:2013
ISSN:0899-0042
Megjegyzések:Three new polyketides ((-)-1, (+)-1, and 2) were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of (-)-1, (+)-1, and 2 were determined by TDDFT ECD calculations of solution conformers, online HPLC-ECD analysis, and the modified Mosher method.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cladanthus
endophyte
Embellisia
structure elucidation
TDDFT ECD calculation
Megjelenés:Chirality. - 25 : 4 (2013), p. 250-256. -
További szerzők:Aly, Amal H. Mándi Attila (1981-) (vegyész, német szakfordító) Wray, Victor Essassi, El Mokhtar Ouchbani, Tarik Bouhfid, Rachid Lin, Wen Han Proksch, Peter Kurtán Tibor (1973-) (vegyész, angol szakfordító) Debbab, Abdessamad
Pályázati támogatás:HURO/0901/274/2.2.2
Egyéb
K105871
OTKA
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9.

001-es BibID:BIBFORM035158
Első szerző:Ebrahim, Weaam
Cím:Decalactone Derivatives from Corynespora cassiicola, an Endophytic Fungus of the Mangrove Plant Laguncularia racemosa / Weaam Ebrahim, Amal H. Aly, Attila Mándi, Frank Totzke, Michael H. G. Kubbutat, Victor Wray, Wen-Han Lin, Haofu Dai, Peter Proksch, Tibor Kurtán, Abdessamad Debbab
Dátum:2012
Megjegyzések:Chemical investigation of the ethyl acetate extract of Corynespora cassiicola, isolated from leaf tissues of the Chinese mangrove medicinal plant Laguncularia racemosa, yielded four new secondary metabolites, including three decalactones, xestodecalactones D-F (1-3) as well as corynesidone C (4), in addition to four known compounds. The structures of the new compounds were determined on the basis of oneand two-dimensional NMR spectroscopy as well as by highresolution mass spectrometry. Absolute configurations of the optically active compounds 1-3 were determined by TDDFT ECD calculations of their solution conformers, proving that they belong to the (11S) series of xestodecalactones, opposite to the (11R) configuration of the known xestodecalactones A-C. All compounds were tested against a panel of human protein kinases. Among the isolated compounds, two inhibited several kinases such as IGF1-R and VEGF-R2 with IC50 values mostly in the low micromolar range.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Natural products
Medicinal chemistry
Drug discovery
Fungi
Structure elucidation
Conformation analysis
Lactones
Molekulatudomány
Megjelenés:European Journal of Organic Chemistry. - 18 (2012), p. 3476-3484. -
További szerzők:Aly, Amal H. Mándi Attila (1981-) (vegyész, német szakfordító) Totzke, Frank Kubbutat, Michael H. G. Wray, Victor Lin, Wen Han Dai, Haofu Proksch, Peter Kurtán Tibor (1973-) (vegyész, angol szakfordító) Debbab, Abdessamad
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
O- és O,N heterociklusok szintézise és kiroptikai vizsgálata
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10.

001-es BibID:BIBFORM085990
035-os BibID:(WOS)000488424000011 (Scopus)85071862421
Első szerző:El-Kashef, Dina H.
Cím:Polyketides and a Dihydroquinolone Alkaloid from a Marine Derived Strain of the Fungus Metarhizium marquandii / Dina H. El-Kashef, Georgios Daletos, Malte Plenker, Rudolf Hartmann, Attila Mándi, Tibor Kurtán, Horst Weber, Wenhan Lin, Elena Ancheeva, Peter Proksch
Dátum:2019
ISSN:0163-3864 1520-6025
Megjegyzések:Three new natural products (1-3), including two butenolide derivatives (1 and 2) and one dihydroquinolone derivative (3), together with nine known natural products were isolated from a marine-derived strain of the fungus Metarhizium marquandii. The structures of the new compounds were unambiguously deduced by spectroscopic means including HRESIMS and 1D/2D NMR spectroscopy, ECD, VCD, OR measurements, and calculations. The absolute configuration of marqualide (1) was determined by a combination of modified Mosher's method with TDDFTECD calculations at different levels, which revealed the importance of intramolecular hydrogen bonding in determining the ECD features. The (3R,4R) absolute configuration of aflaquinolone I (3), determined by OR, ECD, and VCD calculations, was found to be opposite of the (3S,4S) absolute configuration of the related aflaquinolones A-G, suggesting that the fungus M. marquandii produces aflaquinolone I with a different configuration (chiral switching). The absolute configuration of the known natural product terrestric acid hydrate (4) was likewise determined for the first time in this study. TDDFT-ECD calculations allowed determination of the absolute configuration of its chirality center remote from the stereogenic unsaturated ?-lactone chromophore. ECD calculations aided by solvent models revealed the importance of intramolecular hydrogen bond networks in stabilizing conformers and determining relationships between ECD transitions and absolute configurations.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Natural Products. - 82 : 9 (2019), p. 2460-2469. -
További szerzők:Daletos, Georgios Plenker, Malte Hartmann, Rudolf Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Weber, Horst Lin, Wen Han Ancheeva, Elena Proksch, Peter
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
K120181
OTKA
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11.

001-es BibID:BIBFORM069592
Első szerző:Elnaggar, Mohamed S.
Cím:Hydroquinone derivatives from the marine-derived fungus Gliomastix sp. / Mohamed S. Elnaggar, Weaam Ebrahim, Attila Mandi, Tibor Kurtan, Werner E. G. Müller, Rainer Kalscheuer, Abdelnasser Singab, Wenhan Lin, Zhen Liu, Peter Proksch
Dátum:2017
ISSN:2046-2069
Megjegyzések:Eight new hydroquinone derivatives, gliomastins A-D (1-4), 9-O-methylgliomastin C (5), acremonin A 1-O-?-D-glucopyranoside (6), gliomastin E 1-O-?-D-glucopyranoside (7), and 6'-O-acetyl-isohomoarbutin (8), together with seven known analogues were isolated from the marine-derived fungus Gliomastix sp. Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR measurements aided by DFT NMR calculations as well as MS data. TDDFT-ECD and OR calculations were performed to determine the absolute configurations of 1 and the aglycones of 6 and 7. Compound 1 features a novel skeleton, biogenetically derived from a Diels?Alder reaction between derivatives of 11 and 13. Compound 2 represents a rare sulfur-containing alkaloid derived from the known hydroquinone 13. Compounds 1, 10 and 12 showed strong cytotoxicity against the L5178Y mouse lymphoma cell line with IC50 values of 1.8, 1.0 and 1.1 ?M, respectively. Compound 3 exhibited moderate antitubercular activity against Mycobacterium tuberculosis with a MIC value of 12.5 ?M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:RSC Advances. - 7 : 49 (2017), p. 30640-30649. -
További szerzők:Ebrahim, Weaam Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Müller, Werner E. G. Kalscheuer, Rainer Singab, Abdelnasser Lin, Wen Han Liu, Zhen Proksch, Peter
Pályázati támogatás:NKFI K120181
Egyéb
NKFI PD121020
Egyéb
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12.

001-es BibID:BIBFORM063403
Első szerző:Elnaggar, Mohamed S.
Cím:Xanthones and sesquiterpene derivatives from a marine-derived fungus Scopulariopsis sp. / Mohamed S. Elnaggar, Sherif S. Ebada, Mohamed L. Ashour, Weaam Ebrahim, Werner E.G. Müller, Attila Mándi, Tibor Kurtán, Abdelnasser Singab, Wenhan Lin, Zhen Liu, Peter Proksch
Dátum:2016
ISSN:0040-4020
Megjegyzések:Two new xanthone derivatives, 12-dimethoxypinselin (1) and 12-O-acetyl-AGI-B4 (2), as well as two new phenolic bisabolane-type sesquiterpenes, 11,12-dihydroxysydonic acid (15) and 1-hydroxyboivinianic acid (16), together with one new alkaloid, scopulamide (21) and one new alpha-pyrone derivative, scopupyrone (26), in addition to twenty-three known compounds (3-14, 17-20, 22-25, 27-29) were isolated from solid rice cultures of the marine-derived fungus Scopulariopsis sp. obtained from the Red Sea hard coral Stylophora sp. All compounds were unambiguously identified through extensive NMR spectroscopic analyses, and by comparison with the literature. Marfey's reaction was performed to determine the absolute configuration of scopulamide (21) and TDDFT-ECD calculations were used to assign the configuration of AGI-B4 (3) and scopupyrone (26). All isolated compounds were evaluated for their cytotoxicity against L5178Y mouse lymphoma cells and the structure-activity relationships were discussed.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Scopulariopsis sp.
Xanthone
Sesquiterpene
Structural elucidation
Cytotoxicity
Megjelenés:Tetrahedron. - 72 : 19 (2016), p. 2411-2419. -
További szerzők:Ebada, Sherif Saeed Ashour, Mohamed L. Ebrahim, Weaam Müller, Werner E. G. Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Singab, Abdelnasser Lin, Wen Han Liu, Zhen Proksch, Peter
Pályázati támogatás:K105871
OTKA
NIIFI 10038
Egyéb
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DOI
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