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001-es BibID:	BIBFORM044503
Első szerző:	Bara, Robert
Cím:	Atropisomeric Dihydroanthracenones as Inhibitors of Multiresistant Staphylococcus aureus / Robert Bara, Ilka Zerfass, Amal H. Aly, Heike Goldbach-Gecke, Vijay Raghavan, Peter Sass, Attila Mándi, Victor Wray, Prasad L. Polavarapu, Alexander Pretsch, WenHan Lin, Tibor Kurtán, Abdessamad Debbab, Heike Brötz-Oesterhelt, Peter Proksch
Dátum:	2013
ISSN:	0022-2623 1520-4804
Megjegyzések:	Two bisdihydroanthracenone atropodiastereomeric pairs, including homodimeric flavomannin A (1) and the previously unreported flavomannin B (2), two new unsymmetrical dimers (3 and 4), and two new mixed dihydroanthracenone/anthraquinone dimers (5 and 6) were isolated from Talaromyces wortmannii, an endophyte of Aloe vera. The structures of 2?6 were elucidated by extensive NMR and mass spectrometric analyses. The axial chirality of the biaryls was determined using TDDFT ECD and VCD calculations, the combination of which however did not allow the assignment of the central chirality elements of 1. The compounds exhibited antibacterial activity against Staphylococcus aureus, including (multi)drug-resistant clinical isolates. Reporter gene analyses indicated induction of the SOS response for some of the derivatives, suggesting interference with DNA structure or metabolism. Fluorescence microscopy demonstrated defective segregation of the bacterial chromosome and DNA degradation. Notably, the compounds showed no cytotoxic activity, encouraging their further evaluation as potential starting points for antibacterial drug development.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Medicinal Chemistry. - 56 : 8 (2013), p. 3257-3272. -
További szerzők:	Zerfass, Ilka Aly, Amal H. Goldbach-Gecke, Heike Raghavan, Vijay Sass, Peter Mándi Attila (1981-) (vegyész, német szakfordító) Wray, Victor Polavarapu, Prasad L. Pretsch, Alexander Lin, Wen Han Kurtán Tibor (1973-) (vegyész, angol szakfordító) Debbab, Abdessamad Brötz-Oesterhelt, Heike Proksch, Peter
Pályázati támogatás:	K105871 OTKA NIIFI 10038 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM030934
Első szerző:	Debbab, Abdessamad
Cím:	New Anthracene Derivatives - Structure Elucidation and Antimicrobial Activity / Abdessamad Debbab, Amal H. Aly, Ruangelie Edrada-Ebel, Victor Wray, Alexander Pretsch, Gennaro Pescitelli, Tibor Kurtan, Peter Proksch
Dátum:	2012
Megjegyzések:	Three new anthracene derivatives, which include tetrahydroanthraquinone 1 and two tetrahydroanthraquinone heterodimers 2 and 3, were isolated from Stemphylium globuliferum, together with four known metabolites 4-7. Detailed analysis of the spectroscopic data allowed the unambiguous determination of the structures of 1 and 2 and a revision of the structure of alterporriol C and its atropisomer. Furthermore, alterporriol G, previously obtained as part of a mixture, was isolated in its pure form for the first time and its structure was also revised. The absolute configurations of 1, 2 and 3 were assigned by calculation of their CD spectra, which also allowed the configurational assignment of altersolanol A and the determination of the axial chirality of alterporriols D and E. All isolated compounds were analysed for their antimicrobial and cytotoxic activities. Compound 5 inhibited the growth of most pathogenic microorganisms tested, whereas 2, 6 and 7 showed selective inhibition of bacteria but were inactive against fungi.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekulatudomány Natural products Medicinal chemistry Antibiotics Biological activity Quinones Structure elucidation Circular dichroism Density functional calculations
Megjelenés:	European Journal of Organic Chemistry. - 7 (2012), p. 1351-1359. -
További szerzők:	Aly, Amal H. Edrada-Ebel, Ruangelie Wray, Victor Pretsch, Alexander Pescitelli, Gennaro (1972-) (vegyész) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Proksch, Peter
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP O- és O,N heterociklusok szintézise és kiroptikai vizsgálata
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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