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001-es BibID:	BIBFORM064483
035-os BibID:	(WOS)000378758200016 (Scopus)84976433453
Első szerző:	Zhang, Haibo
Cím:	Alpha-Pyrones with Diverse Hydroxy Substitutions from Three Marine-Derived Nocardiopsis Strains / Haibo Zhang, Kumar Saurav, Ziquan Yu, Attila Mándi, Tibor Kurtán, Jie Li, Xinpeng Tian, Qingbo Zhang, Wenjun Zhang, Changsheng Zhang
Dátum:	2016
ISSN:	0163-3864 1520-6025
Megjegyzések:	Eight new alpha-pyrones 1-8 and three known alpha-pyrones 9-11 were isolated from three marine-derived Nocardiopsis strains SCSIO 10419, SCSIO 04583, and SCSIO KS107. The structures of compounds 1-8 were elucidated by comprehensive spectral analyses. The absolute configurations of 4-deoxyphomapyrone C (1), 4-deoxy-11-hydroxyphomapyrone C (3), 4-deoxy-7R-hydroxyphomapyrone C (5), and phomapyrone C (11) were determined by TDDFT-ECD calculations for the solution conformers, which revealed that the conformation of the side chain was decisive for the sign of the characteristic high-wavelength ECD transition. (-)-4-Deoxy-8-hydroxyphomapyrone C (4) was isolated from SCSIO 10419 and was deduced as a diastereomeric mixture containing (8S)- and (8R)-4-deoxy-8-hydroxyphomapyrone C in a ratio of 2.6:1 (8R:8S), by chiral phase HPLC analysis and Mosher's ester analysis. Interestingly, 7-hydroxymucidone (9) was isolated from both SCSIO 04583 and SCSIO KS107, as an enantiomeric mixture containing (7S)-hydroxymucidone (major in 9 from SCSIO 04583) and (7R)-hydroxymucidone (major in 9 from SCSIO KS107). alpha-Pyrones 3-5 were identified as three isomers of phomapyrone C (II) with diverse hydroxy substitutions. alpha-Pyrones 10-hydroxymucidone (6), 4-hydroxymucidone (8), and 9, differed in the position of the hydroxy group. Several alpha-pyrones exhibited moderate growth inhibitory activity against Micrococcus luteus and Bacillus subtilis.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Natural Products. - 79 : 6 (2016), p. 1610-1618. -
További szerzők:	Saurav, Kumar Yu, Ziquan Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Li, Jie Tian, Xinpeng Zhang, Qingbo Zhang, Wenjun Zhang, Changsheng
Pályázati támogatás:	K105871 OTKA NIIFI 10038 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM037349
Első szerző:	Zhang, Qingbo
Cím:	N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete / Qingbo Zhang, Attila Mándi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtán, Changsheng Zhang
Dátum:	2012
Megjegyzések:	Four new indolo-sesquiterpenes - dixiamycins A (1) and B (2), oxiamycin (3), and chloroxiamycin (4) - were isolated from a marine-derived Actinomycete and characterized, together with the known compound xiamycin A (5). Dixiamycins A (1) and B (2) are the first examples of atropisomerism of naturally occurring N-N-coupled atropo-diastereomers, with a dimeric indolo-sesquiterpene skeleton and a stereo genic N-N axis between sp3-hybridized nitrogen atoms. Solution TDDFT ECD calculations were utilized to ascertain the axial chirality of 1 and 2, and rotational barriers and transitions states of the inversion were calculated. Oxiamycin (3) contains a seven-membered 2,3,4,5-tetrahydrooxepine ring. The two dimeric compounds 1 and 2 showed better antibacterial activities than the monomers 3-5.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Natural products Terpenoids Xiamycin Atropisomerism Configuration determination Density functional calculations
Megjelenés:	European Journal of Organic Chemistry. - 27 (2012), p. 5256-5262. -
További szerzők:	Mándi Attila (1981-) (vegyész, német szakfordító) Li, Sumei Chen, Yuchan Zhang, Wenjun Tian, Xinpeng Zhang, Haibo Li, Huixian Zhang, Weimin Zhang, Si Ju, Jianhua Kurtán Tibor (1973-) (vegyész, angol szakfordító) Zhang, Changsheng
Pályázati támogatás:	HURO/0901/274/2.2.2 Egyéb NIIFI 10038 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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