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001-es BibID:BIBFORM066440
Első szerző:Tóth Barbara
Cím:Screening of Luzula species native to the Carpathian Basin for anti-inflammatory activity and bioactivity-guided isolation of compounds from Luzula luzuloides (Lam.) Dandy & Wilmott / Barbara Tóth, Fang-Rong Chang, Tsong-Long Hwang, Ádám Szappanos, Attila Mándi, Attila Hunyadi, Tibor Kurtán, Gusztáv Jakab, Judit Hohmann, Andrea Vasas
Dátum:2017
ISSN:0367-326X
Megjegyzések:The present study focused on the anti-in flammatory screening of Luzula species native to the Carpathian Basin and bioactivity-guided isolation of compounds ofLuzula luzuloides (Lam.) Dandy & Wilmott. The anti-in flammatory properties of extracts with different polarity prepared from Luzula species were determined. Among them, the CH2Cl2-soluble fraction of L. luzuloides possessed strong inhibitory effects on superoxide anion generation (99.39 ? 0.37%) and elastase release (114.22 ? 3.13%) in fMLP/CB-induced human neutrophils at concentration of 10 ?g/mL. From this fraction, six compounds (1-6) were isolated by the combination of different chromatographic methods. The structures of the compounds were determined by means of MS, 1D and 2D NMR spectroscopy. The results allowed the identi fication of the new 1,6-dihydroxy-2-keto-1,7-dimethyl-8-vinyl-1,2-dihydrophenanthrene (1) from the plant, named luzulin A. Chiral HPLC and HPLC-ECD analysis revealed that 1 possesses low enantiomeric excess and TDDFT-ECD calculations afforded the con figurational assignment of the separated enantiomers. Three known phenanthrenes [juncuenin B (2), dehydrojuncuenin B (3) and juncusol (4)] and two flavonoids [apigenin (5) and luteolin (6)] were also isolated. The anti-in flammatory activity of the isolated compounds was tested and IC50 values were determined. This was the first time that phenanthrenes were detected in a Luzula species. The oxidative transformation of juncuenin B (3) led to the isolation of its possible biometabolites, namely luzulin A (1), dehydrojuncuenin B (4), and juncuenin D (7). The isolated compounds (1-4) con firm that besides flavonoids, phenanthrenes could also serve as chemotaxonomic markers for Luzula species and prove the close relationship of Juncus and Luzula genus.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Juncaceae
Luzula luzuloides
Phenanthrenes
Flavonoids
Anti-in flammatory activity
Electronic circular dichroism
Megjelenés:Fitoterapia 116 (2017), p. 131-138. -
További szerzők:Chang, Fang-Rong Hwang, Tsong-Long Szappanos Ádám (1989-) (vegyész) Mándi Attila (1981-) (vegyész, német szakfordító) Hunyadi Attila Kurtán Tibor (1973-) (vegyész, angol szakfordító) Jakab Gusztáv Hohmann Judit Vasas Andrea
Pályázati támogatás:K109846
OTKA
NKFI K 120181, PD 121020
Egyéb
NIIFI 10038
Egyéb
Internet cím:DOI
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